The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Rai1  -  retinoic acid induced 1

Mus musculus

Synonyms: Gt1, Kiaa1820, Retinoic acid-induced protein 1
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Rai1


High impact information on Rai1


Psychiatry related information on Rai1


Chemical compound and disease context of Rai1


Biological context of Rai1


Anatomical context of Rai1


Associations of Rai1 with chemical compounds

  • We found that stable expression of SF-1 is sufficient to alter ES cell morphology, permit cyclic AMP (cAMP) and retinoic acid-induced expression of the endogenous side chain cleavage enzyme gene, and consequently, promote steroidogenesis [22].
  • Increased levels of several retinoid binding proteins resulting from retinoic acid-induced differentiation of F9 cells [23].
  • Despite the fact that retinoic acid-induced differentiation of F9 cells promotes increased levels of several proteins involved in the normal metabolism of vitamin A, no evidence was obtained to suggest that the cells were dependent on retinoids to maintain their differentiated state [23].
  • To explore the mechanism of these effects, several mutant cell clones resistant to retinoic acid-induced growth inhibition have been derived from the S91-C-2 cells by exposing them to the mutagen ethyl methane sulfonate and plating in soft agarose in the presence of 1 microM beta-all-trans-retinoic acid [24].
  • Treatment of P19 cells with the Na+/H+ exchanger inhibitor Hoe 694 eliminated retinoic acid-induced differentiation in this cell line [25].

Physical interactions of Rai1


Regulatory relationships of Rai1


Other interactions of Rai1


Analytical, diagnostic and therapeutic context of Rai1


  1. Inactivation of Rai1 in mice recapitulates phenotypes observed in chromosome engineered mouse models for Smith-Magenis syndrome. Bi, W., Ohyama, T., Nakamura, H., Yan, J., Visvanathan, J., Justice, M.J., Lupski, J.R. Hum. Mol. Genet. (2005) [Pubmed]
  2. Lipid composition and lateral diffusion in plasma membranes of teratocarcinoma-derived cell lines. Searls, D.B., Edidin, M. Cell (1981) [Pubmed]
  3. Decreased c-myc expression is an early event in retinoic acid-induced differentiation of F9 teratocarcinoma cells. Griep, A.E., DeLuca, H.F. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  4. Retinoic acid-induced spina bifida: evidence for a pathogenetic mechanism. Alles, A.J., Sulik, K.K. Development (1990) [Pubmed]
  5. Chemically induced differentiation of murine embryonal carcinoma in vivo: transplantation of differentiated tumors. Speers, W.C., Altmann, M. Cancer Res. (1984) [Pubmed]
  6. DNA fragments from F9 PyEC mutants increase expression of heterologous genes in transfected F9 cells. Linney, E., Donerly, S. Cell (1983) [Pubmed]
  7. Retinoic acid alters hindbrain Hox code and induces transformation of rhombomeres 2/3 into a 4/5 identity. Marshall, H., Nonchev, S., Sham, M.H., Muchamore, I., Lumsden, A., Krumlauf, R. Nature (1992) [Pubmed]
  8. Regulation of Ras-MAPK pathway mitogenic activity by restricting nuclear entry of activated MAPK in endoderm differentiation of embryonic carcinoma and stem cells. Smith, E.R., Smedberg, J.L., Rula, M.E., Xu, X.X. J. Cell Biol. (2004) [Pubmed]
  9. Bcl-2 inhibits retinoic acid-induced apoptosis during the neural differentiation of embryonal stem cells. Okazawa, H., Shimizu, J., Kamei, M., Imafuku, I., Hamada, H., Kanazawa, I. J. Cell Biol. (1996) [Pubmed]
  10. A retinoic acid responsive gene MK found in the teratocarcinoma system is expressed in spatially and temporally controlled manner during mouse embryogenesis. Kadomatsu, K., Huang, R.P., Suganuma, T., Murata, F., Muramatsu, T. J. Cell Biol. (1990) [Pubmed]
  11. Rai1 deficiency in mice causes learning impairment and motor dysfunction, whereas Rai1 heterozygous mice display minimal behavioral phenotypes. Bi, W., Yan, J., Shi, X., Yuva-Paylor, L.A., Antalffy, B.A., Goldman, A., Yoo, J.W., Noebels, J.L., Armstrong, D.L., Paylor, R., Lupski, J.R. Hum. Mol. Genet. (2007) [Pubmed]
  12. Retinoic acid-induced rapid loss of nuclear cyclic AMP-dependent protein kinase in teratocarcinoma cells. Plet, A., Evain-Brion, D., Gerbaud, P., Anderson, W.B. Cancer Res. (1987) [Pubmed]
  13. Induction of expression of the alpha v beta 1 and alpha v beta 3 integrin heterodimers during retinoic acid-induced neuronal differentiation of murine embryonal carcinoma cells. Dedhar, S., Robertson, K., Gray, V. J. Biol. Chem. (1991) [Pubmed]
  14. Retinoic acid-induced differentiation of the mouse teratocarcinoma cell line F9 is accompanied by an increase in the activity of UDP-galactose: beta-D-galactosyl-alpha 1,3-galactosyltransferase. Cummings, R.D., Mattox, S.A. J. Biol. Chem. (1988) [Pubmed]
  15. Enhancement of cisplatin and etoposide cytotoxicity after all-trans retinoic-acid-induced cellular differentiation of a murine embryonal carcinoma cell line. Guchelaar, H.J., Timmer-Bosscha, H., Dam-Meiring, A., Uges, D.R., Oosterhuis, J.W., de Vries, E.G., Mulder, N.H. Int. J. Cancer (1993) [Pubmed]
  16. Characterization of genes which exhibit reduced expression during the retinoic acid-induced differentiation of F9 teratocarcinoma cells: involvement of cyclin D3 in RA-mediated growth arrest. Faria, T.N., LaRosa, G.J., Wilen, E., Liao, J., Gudas, L.J. Mol. Cell. Endocrinol. (1998) [Pubmed]
  17. SV40 enhancer activation during retinoic acid-induced differentiation of F9 embryonal carcinoma cells. Sleigh, M.J., Lockett, T.J. EMBO J. (1985) [Pubmed]
  18. Transcription of the simian virus 40 genome in DNA-transformed murine teratocarcinoma stem cells. Linnenbach, A., Huebner, K., Croce, C.M. Proc. Natl. Acad. Sci. U.S.A. (1981) [Pubmed]
  19. Multipotent hematopoietic cell lines derived from C/EBPalpha(-/-) knockout mice display granulocyte macrophage-colony-stimulating factor, granulocyte- colony-stimulating factor, and retinoic acid-induced granulocytic differentiation. Collins, S.J., Ulmer, J., Purton, L.E., Darlington, G. Blood (2001) [Pubmed]
  20. Retinoic acid-induced developmental defects are mediated by RARbeta/RXR heterodimers in the pharyngeal endoderm. Matt, N., Ghyselinck, N.B., Wendling, O., Chambon, P., Mark, M. Development (2003) [Pubmed]
  21. Expression of a dominant-negative retinoic acid receptor construct reduces retinoic acid metabolism and retinoic acid-induced inhibition of NIH-3T3 cell growth. Isogai, M., Chiantore, M.V., Haque, M., Scita, G., De Luca, L.M. Cancer Res. (1997) [Pubmed]
  22. Nuclear receptor steroidogenic factor 1 directs embryonic stem cells toward the steroidogenic lineage. Crawford, P.A., Sadovsky, Y., Milbrandt, J. Mol. Cell. Biol. (1997) [Pubmed]
  23. Increased levels of several retinoid binding proteins resulting from retinoic acid-induced differentiation of F9 cells. Eriksson, U., Hansson, E., Nilsson, M., Jönsson, K.H., Sundelin, J., Peterson, P.A. Cancer Res. (1986) [Pubmed]
  24. Isolation and analysis of melanoma cell mutants resistant to the antiproliferative action of retinoic acid. Lotan, R., Stolarsky, T., Lotan, D. Cancer Res. (1983) [Pubmed]
  25. The Na+/H+ antiporter potentiates growth and retinoic acid-induced differentiation of P19 embryonal carcinoma cells. Wang, H., Singh, D., Fliegel, L. J. Biol. Chem. (1997) [Pubmed]
  26. Regulation of E2F/cyclin A-containing complex upon retinoic acid-induced differentiation of teratocarcinoma cells. Reichel, R.R. Gene Expr. (1992) [Pubmed]
  27. Okadaic acid suppresses neural differentiation-dependent expression of the neurofilament-L gene in P19 embryonal carcinoma cells by post-transcriptional modification. Sasahara, Y., Kobayashi, T., Onodera, H., Onoda, M., Ohnishi, M., Kato, S., Kusuda, K., Shima, H., Nagao, M., Abe, H., Yanagawa, Y., Hiraga, A., Tamura, S. J. Biol. Chem. (1996) [Pubmed]
  28. X-chromosome inactivation in hybrid embryonic carcinoma cells upon differentiation. Park, J.G., Lee, K.H. Mol. Cells (1997) [Pubmed]
  29. Temporally regulated expression of Lin-28 in diverse tissues of the developing mouse. Yang, D.H., Moss, E.G. Gene Expr. Patterns (2003) [Pubmed]
  30. Differential expression of fetomodulin and tissue plasminogen activator to characterize parietal endoderm differentiation of F9 embryonal carcinoma cells. Imada, S., Yamaguchi, H., Imada, M. Dev. Biol. (1990) [Pubmed]
  31. Expression of Sec61 alpha in F9 and P19 teratocarcinoma cells after retinoic acid treatment. Ferreira, L.R., Velano, C.E., Braga, E.C., Paula, C.C., Martélli-Júnior, H., Sauk, J.J. Brazilian journal of biology = Revista brasleira de biologia. (2003) [Pubmed]
  32. Expression of the murine Hoxa4 gene requires both autoregulation and a conserved retinoic acid response element. Packer, A.I., Crotty, D.A., Elwell, V.A., Wolgemuth, D.J. Development (1998) [Pubmed]
  33. The mouse extracellular signal-regulated kinase 2 gene. Gene structure and characterization of the promoter. Sugiura, N., Suga, T., Ozeki, Y., Mamiya, G., Takishima, K. J. Biol. Chem. (1997) [Pubmed]
  34. TGF-beta modulates the expression of retinoic acid-induced RAR-beta in primary cultures of embryonic palate cells. Nugent, P., Potchinsky, M., Lafferty, C., Greene, R.M. Exp. Cell Res. (1995) [Pubmed]
  35. Adenovirus E1A functions as a cofactor for retinoic acid receptor beta (RAR beta) through direct interaction with RAR beta. Folkers, G.E., van der Saag, P.T. Mol. Cell. Biol. (1995) [Pubmed]
  36. Mouse embryos lacking RXR alpha are resistant to retinoic-acid-induced limb defects. Sucov, H.M., Izpisúa-Belmonte, J.C., Gañan, Y., Evans, R.M. Development (1995) [Pubmed]
  37. Regulation of J6 gene expression by transcription factor GATA-4. Bielinska, M., Wilson, D.B. Biochem. J. (1995) [Pubmed]
  38. Efficiency of neural differentiation of mouse P19 embryonal carcinoma cells is dependent on the seeding density. Kitani, H., Ikeda, H., Atsumi, T., Watanabe, R. Cell transplantation. (1997) [Pubmed]
  39. Prevention of retinoic acid-induced early craniofacial abnormalities by folinic acid and expression of endothelin-1/dHAND in the branchial arches in mouse. Zhang, Z., Xu, Y., Li, L., Han, J., Zheng, L., Liu, P., Li, Y. Br. J. Nutr. (2006) [Pubmed]
  40. Development of mouse limbs in organ culture: dose dependent retinoic acid-induced defects evaluated using image analysis. Kwasigroch, T.E., Skalko, R.G. Prog. Clin. Biol. Res. (1983) [Pubmed]
  41. Mouse limb bud development in submerged culture: quantitative assessment of the effects of in vivo exposure to retinoic acid. Kwasigroch, T.E., Skalko, R.G., Church, J.K. Teratog., Carcinog. Mutagen. (1984) [Pubmed]
WikiGenes - Universities