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Gene Review

BFPyV_gp5  -  large T antigen

Budgerigar fledgling disease virus - 1

 
 
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Disease relevance of BFPyVgp5

 

High impact information on BFPyVgp5

  • Cells transformed by Polyoma virus (Py) can undergo a high rate of excision or amplification of integrated viral DNA sequences, and these phenomena require the presence of homology (i.e., repeats) within the viral insertion as well as a functional viral large T antigen (T-Ag) [6].
  • Phosphorylation is not diminished in extracts of polyoma tsA mutant-infected cells shifted to the nonpermissive temperature late in infection, conditions which inactivate the large T antigen [7].
  • By 48 h after infection, almost all (92.8%) bovine corneal endothelial cells expressed large T antigen [5].
  • Bovine and human corneal endothelial cells which expressed large T antigen proliferated and the characteristic morphologic features of corneal endothelium were maintained [5].
  • In contrast, large T antigen alone is sufficient to induce tumors in the endocrine pancreas and thymus [2].
 

Chemical compound and disease context of BFPyVgp5

 

Biological context of BFPyVgp5

  • We present evidence that the large T antigen interacts specifically with DNA sequences present in the non-coding region of BFDV; by indirect DNA immunoprecipitation mapping and DNase I footprinting, four regions including 12 DNA-binding sites have been determined that cover most of the BFDV non-coding region [9].
  • Our results are compatible with the hypothesis that large T antigen destabilizes the cellular genome, and that specific mutations arising from this process may contribute to cell immortalization [10].
  • Simian virus 40 (SV40) and polyomavirus (Py) DNA replication require cellular proteins and a virus-encoded early gene product, large T antigen (SVT and PyT, respectively) [11].
  • This recombinant plasmid, pSV01, binds to a purified T antigen in vitro and replicates in monkey cells when supplied with large T antigen [12].
  • Activation of IFN-stimulated gene factor 3 was inhibited in cells derived from a tumor induced by wild-type MPyV but not those from a mutant that lacks the pRB binding site of the large T antigen [13].
 

Anatomical context of BFPyVgp5

  • SV40 small t antigen which has previously been considered unable to transform cultured cells by itself, was nevertheless able to transform sup+ BHK lines to anchorage independence in the absence of the viral large T antigen [14].
  • Umbilical cord endothelial cells expressing large T antigen: comparison with primary cultures and effect of cell age [15].
  • By using micro-positron-emission tomography, interactions between p53 tumor suppressor and the large T antigen of simian virus 40 were visualized in tumor xenografts of HeLa cells stably transfected with the imaging constructs [16].
  • Infection of primary human prostate epithelial cells with BK polyomavirus dramatically induced Dnmt1 transcription following large T antigen (TAg) translation and E2F activation [17].
  • When grown in 100 microM Zn2+, transformed myocytes expressed the large T antigen, divided rapidly, and acquired an apparently unlimited proliferative capacity [18].
 

Associations of BFPyVgp5 with chemical compounds

  • The viral large T antigen bound to Janus tyrosine kinase 1 and inactivated signaling through IFN receptors [13].
  • Large T antigen of SV40 interacts with p53, pRb/p107/p130 family members, and the cyclic AMP-responsive element-binding protein (CREB)-binding protein (CBP)/p300 [19].
  • Thus the loss of the growth inhibitory effect of vitamin D3 in HBL100 cells may be caused by the expression of the large T antigen in the cells, and provide further evidence that VDR is required for efficient growth inhibition by vitamin D3 [20].
  • Only 2 cases showed strong/diffuse and moderate/focal staining for LTag with both representing invasive high-grade urothelial carcinoma (where no inclusions were seen on hematoxylin and eosin-stained sections) and both demonstrating positive immunostaining for p53 [21].
  • Sodium butyrate treatment did, however, result in the appearance of a new nuclear protein which bound specifically to a SV40 promoter fragment containing large-T antigen binding sites I and II [22].
 

Other interactions of BFPyVgp5

  • A recombinant virus containing a genomic copy of the BFDV early region was used for small t antigen expression, and corresponding intron-deleted cDNAs for production of large T antigen derivatives [9].
 

Analytical, diagnostic and therapeutic context of BFPyVgp5

References

  1. The genome of budgerigar fledgling disease virus, an avian polyomavirus. Rott, O., Kröger, M., Müller, H., Hobom, G. Virology (1988) [Pubmed]
  2. Role of the amino-terminal domain of simian virus 40 early region in inducing tumors in secretin-expressing cells in transgenic mice. Ratineau, C., Ronco, A., Leiter, A.B. Gastroenterology (2000) [Pubmed]
  3. Interaction of retinoblastoma protein family members with large T-antigen of primate polyomaviruses. White, M.K., Khalili, K. Oncogene (2006) [Pubmed]
  4. T antigens of simian virus 40: molecular chaperones for viral replication and tumorigenesis. Sullivan, C.S., Pipas, J.M. Microbiol. Mol. Biol. Rev. (2002) [Pubmed]
  5. Expression of SV40 virus large T antigen by recombinant adenoviruses activates proliferation of corneal endothelium in vitro. Feldman, S.T., Gjerset, R., Gately, D., Chien, K.R., Feramisco, J.R. J. Clin. Invest. (1993) [Pubmed]
  6. Amplification and excision of integrated polyoma DNA sequences require a functional origin of replication. Pellegrini, S., Dailey, L., Basilico, C. Cell (1984) [Pubmed]
  7. An activity phosphorylating tyrosine in polyoma T antigen immunoprecipitates. Eckhart, W., Hutchinson, M.A., Hunter, T. Cell (1979) [Pubmed]
  8. Induction and bypass of p53 during productive infection by polyomavirus. Dey, D., Dahl, J., Cho, S., Benjamin, T.L. J. Virol. (2002) [Pubmed]
  9. Expression and DNA binding of budgerigar fledgling disease virus large T antigen. Luo, D., Müller, H., Tang, X.B., Hobom, G. J. Gen. Virol. (1994) [Pubmed]
  10. Expression of SV40 large T antigen, but not small t antigen, is required for the induction of chromosomal aberrations in transformed human cells. Stewart, N., Bacchetti, S. Virology (1991) [Pubmed]
  11. Cell specificity of transcription regulation by papovavirus T antigens and DNA replication. Munholland, J.M., Kelly, J.J., Hassell, J.A., Wildeman, A.G. EMBO J. (1992) [Pubmed]
  12. Construction and analysis of simian virus 40 origins defective in tumor antigen binding and DNA replication. Myers, R.M., Tjian, R. Proc. Natl. Acad. Sci. U.S.A. (1980) [Pubmed]
  13. The polyoma virus T antigen interferes with interferon-inducible gene expression. Weihua, X., Ramanujam, S., Lindner, D.J., Kudaravalli, R.D., Freund, R., Kalvakolanu, D.V. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  14. Influence of a hamster tumor suppressor gene on transformation by viral and cellular oncogenes. Benton, B.K., Volpert, O.V., Bouck, N.P. Carcinogenesis (1993) [Pubmed]
  15. Umbilical cord endothelial cells expressing large T antigen: comparison with primary cultures and effect of cell age. Fitzgerald, U., Hettle, S., MacDonald, C., McLean, J.S. In Vitro Cell. Dev. Biol. Anim. (2000) [Pubmed]
  16. Noninvasive imaging of protein-protein interactions in living animals. Luker, G.D., Sharma, V., Pica, C.M., Dahlheimer, J.L., Li, W., Ochesky, J., Ryan, C.E., Piwnica-Worms, H., Piwnica-Worms, D. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  17. Inhibition of DNA methyltransferase activity prevents tumorigenesis in a mouse model of prostate cancer. McCabe, M.T., Low, J.A., Daignault, S., Imperiale, M.J., Wojno, K.J., Day, M.L. Cancer Res. (2006) [Pubmed]
  18. Transfection of human skeletal muscle cells with SV40 large T antigen gene coupled to a metallothionein promoter. Hurko, O., McKee, L., Zuurveld, J.G. Ann. Neurol. (1986) [Pubmed]
  19. Binding of p300/CBP co-activators by polyoma large T antigen. Cho, S., Tian, Y., Benjamin, T.L. J. Biol. Chem. (2001) [Pubmed]
  20. Resistance of HBL100 human breast epithelial cells to vitamin D action. Agadir, A., Lazzaro, G., Zheng, Y., Zhang, X.K., Mehta, R. Carcinogenesis (1999) [Pubmed]
  21. Polyoma virus-associated cellular changes in the urine and bladder biopsy samples: a cytohistologic correlation. Herawi, M., Parwani, A.V., Chan, T., Ali, S.Z., Epstein, J.I. Am. J. Surg. Pathol. (2006) [Pubmed]
  22. Elevation of large-T antigen production by sodium butyrate treatment of SV40-transformed WI-38 fibroblasts. Goldberg, Y.P., Leaner, V.D., Parker, M.I. J. Cell. Biochem. (1992) [Pubmed]
  23. Development and characterization of a conditionally transformed adult human osteoblastic cell line. Bodine, P.V., Trailsmith, M., Komm, B.S. J. Bone Miner. Res. (1996) [Pubmed]
  24. Gene targeting in rat embryo fibroblasts promoted by the polyomavirus large T antigen. Francès, V., Bastin, M. Nucleic Acids Res. (1996) [Pubmed]
  25. Amplification of JC virus DNA from brain and cerebrospinal fluid of patients with progressive multifocal leukoencephalopathy. Henson, J., Rosenblum, M., Armstrong, D., Furneaux, H. Neurology (1991) [Pubmed]
  26. Polyomavirus late leader region serves an essential spacer function necessary for viability and late gene expression. Adami, G.R., Carmichael, G.G. J. Virol. (1986) [Pubmed]
  27. Subcellular distribution of simian virus 40 T antigen species in various cell lines: the 56K protein. Luborsky, S.W., Chandrasekaran, K. Int. J. Cancer (1980) [Pubmed]
 
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