Disease relevance of GLIS1

• This, in association with its induction in psoriasis, suggests that transcriptional factor Glis1 is involved in the regulation of aberrant differentiation observed in psoriatic epidermis [1].
• A similar induction of Glis1 mRNA by PMA treatment was observed in the immortalized epidermal keratinocyte cell line NHEK-HPV, whereas PMA did not induce Glis1 in HaCaT cells or in several squamous cell carcinoma cell lines [1].
• To determine whether the presence of edible dormice (Glis glis) amplifies the risk of human infection by the Lyme disease spirochete (Borrelia burgdorferi), the capacity of dormice as reservoir hosts was compared with that of other potential reservoirs in a central European site where risk of human infection is intense [2].
• Pituitary beta-endorphin content during spontaneous food intake and body weight cycles in the dormouse, Glis glis [3].
• 5-Fluorouracil plus 5-methyltetrahydrofolate in advanced pancreatic cancer. GLISP (Gruppo Ligure Studio Pancreas) [4].

High impact information on GLIS1

• Intrinsic connections within the tree shrew (Tupaia glis) visual cortex (area 17) are organized in periodic stripelike patterns within layers I, II, and III [5].
• To obtain insight into its function, Glis1 and a C-terminal deletion mutant Glis1DeltaC were expressed in NHEK-HPV cells and changes in epidermal differentiation and gene expression examined [1].
• Our results, partly in contradiction to earlier studies using different tracing techniques in another tree shrew species (Tupaia glis), reveal that hypothalamic nuclei, in particular the SCN, are contacted by retino-afferent fibers which are thought to mediate the effects of light to the endogenous 'clock' and to parts of the neuroendocrine system [6].
• Previous studies in tree shrews (Tupaia glis belangeri) suggest that regulation of the mechanical properties of the sclera may be an important part of the mechanism that controls the axial elongation rate in this mammal [7].
• It then presents data on the fat cell number and size in the retroperitoneal and gonadal fat depots of dormice, Glis glis, over the course of their body weight cycles [8].

Biological context of GLIS1

• GLIS3 is an 83.8 kDa nuclear protein containing five C2H2-type Krüppel-like zinc finger motifs that exhibit 93% identity with those of GLIS1, however, little homology exists outside their zinc finger domains [9].
• Amino acid sequences of the aplpha and beta chains of adult hemoglobin of the tupai, Tupaia glis [10].
• In the present study we examine the same tissues in euthermic and hibernating individuals of the edible dormouse Glis glis in order to investigate possible modifications of nuclear structural constituents occurring during hibernation in this species [11].
• Moreover, meiotic studies demonstrated that a synaptonemal complex is formed at one telomeric end of the XY bivalent during the pachytene stage of meiosis in a male T. glis specimen [12].

Anatomical context of GLIS1

• In this study, we analyze the expression and potential function of the Krüppel-like zinc-finger protein Gli-similar protein 1 (Glis1) in normal and inflammatory skin and in the differentiation of epidermal keratinocytes [1].
• This new retino-anterodorsal thalamic projection, together with the known anterior thalamic-retrosplenial projection, represents a third visual pathway in Tupaia glis distinct from the retino-geniculo-striatal and retino-tecto-pulvinar-peristriatal systems [13].
• After unilateral enucleation in the tree shrew (Tupaia glis), axo-dendritic synapses degenerate within two secondary visual centers (intergeniculate and lateral pulvinar nuclei) [14].
• Stereo architecture of the connective tissue cores of the lingual papillae in the treeshrew (Tupaia glis) [15].
• Within the cerebral parenchyma, mast cells were confined to the dorsal diencephalon of Erinaceus europaeus (hedgehog), Tupaia glis (tree-shrew) and Nycticebus coucang (slow loris) [16].

Associations of GLIS1 with chemical compounds

• Globin prepared from hemoglobin of adult tupai (Tupaia glis) was separated into alpha and beta polypeptide chains by CM-cellulose column chromatography [10].

Other interactions of GLIS1

• GLIS3, a novel member of the GLIS subfamily of Krüppel-like zinc finger proteins with repressor and activation functions [9].

Analytical, diagnostic and therapeutic context of GLIS1

• This study investigated the organization of the dorsal lateral geniculate nucleus (LGN) of the tree shrew (Tupaia glis) using both microelectrode recording and anatomical techniques [17].
• The stereo architecture of the lingual connective tissue cores (CTC) in the treeshrew (Tupaia glis) (which has the primitive characteristics of primates) was observed by scanning electron microscopy, and compared to that of other animal orders [15].
• Seroprevalence surveys have shown the presence of toxoplasmosis in local meat animals (sheep, pigs and cattle) and Toxoplasma strains have been isolated from the pig, tree shrew (Tupaia glis), slow loris (Nycticebus coucang) and guinea pigs [18].

References