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Gene Review

Magi1  -  membrane associated guanylate kinase, WW...

Mus musculus

Synonyms: AIP3, BAI1-associated protein 1, BAP-1, BAP1, Baiap1, ...
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Disease relevance of Magi1

  • Moreover, mice and nonhuman primates vaccinated with formaldehyde-treated, thermally inactivated virions produce antibodies capable of neutralizing heterologous strains of HIV in peripheral blood mononuclear cell-, MAGI cell-, and U87-based infectivity assays [1].
  • Only Magi 6 did not compete with the scorpion toxin LqhalphaIT in binding to site 3 despite high toxicity on lepidoptera larvae of 3.1 nmol/g. The K(i)s of other toxins were between 50 pM for Magi 4 and 1747 nM for Magi 1 [2].

High impact information on Magi1


Biological context of Magi1

  • In this report, we describe the cDNA cloning and subcellular distribution of MAGI-1, a MAGUK with three unique structural features: 1) the GuK domain is at the NH2 terminus, 2) the SH3 domain is replaced by two WW domains, and 3) it contains five PDZ domains [4].
  • Because we have previously observed MAGI-1 expression in glomerular visceral epithelial cells (podocytes) of the kidney, we screened a glomerular cDNA library to identify the potential binding partners of MAGI-1 and isolated a partial cDNA encoding a novel protein [5].
  • Scanning the BPV-1 genome for potential binding sequences, an intragenic AP-1 site (BAP-1) within the E7 open reading frame was detected [6].
  • Moreover, the amino acid sequence of Magi 4, which was revealed by cloning of its cDNA, displays similarities to the Na+ channel modifier delta-atracotoxin from the Australian spider Atrax robustus (Hexathelidae) [2].
  • In addition, only Magi 5 binds to both site 3 in insects (K(i)=267 nM) and site 4 in rat brain synaptosomes (K(i)=1.2 nM), whereas it showed no affinities for either mammal binding site 3 or insect binding site 4 [2].

Anatomical context of Magi1


Associations of Magi1 with chemical compounds


Other interactions of Magi1


Analytical, diagnostic and therapeutic context of Magi1


  1. Induction of humoral immune responses following vaccination with envelope-containing, formaldehyde-treated, thermally inactivated human immunodeficiency virus type 1. Poon, B., Safrit, J.T., McClure, H., Kitchen, C., Hsu, J.F., Gudeman, V., Petropoulos, C., Wrin, T., Chen, I.S., Grovit-Ferbas, K. J. Virol. (2005) [Pubmed]
  2. Distinct primary structures of the major peptide toxins from the venom of the spider Macrothele gigas that bind to sites 3 and 4 in the sodium channel. Corzo, G., Gilles, N., Satake, H., Villegas, E., Dai, L., Nakajima, T., Haupt, J. FEBS Lett. (2003) [Pubmed]
  3. JAM4, a junctional cell adhesion molecule interacting with a tight junction protein, MAGI-1. Hirabayashi, S., Tajima, M., Yao, I., Nishimura, W., Mori, H., Hata, Y. Mol. Cell. Biol. (2003) [Pubmed]
  4. MAGI-1, a membrane-associated guanylate kinase with a unique arrangement of protein-protein interaction domains. Dobrosotskaya, I., Guy, R.K., James, G.L. J. Biol. Chem. (1997) [Pubmed]
  5. Identification and characterization of a novel tight junction-associated family of proteins that interacts with a WW domain of MAGI-1. Patrie, K.M. Biochim. Biophys. Acta (2005) [Pubmed]
  6. Tyrphostin AG 555 inhibits bovine papillomavirus transcription by changing the ratio between E2 transactivator/repressor function. Baars, S., Bachmann, A., Levitzki, A., Rösl, F. J. Biol. Chem. (2003) [Pubmed]
  7. Endothelial adhesion molecule ESAM binds directly to the multidomain adaptor MAGI-1 and recruits it to cell contacts. Wegmann, F., Ebnet, K., Du Pasquier, L., Vestweber, D., Butz, S. Exp. Cell Res. (2004) [Pubmed]
  8. Carom: a novel membrane-associated guanylate kinase-interacting protein with two SH3 domains. Ohno, H., Hirabayashi, S., Kansaku, A., Yao, I., Tajima, M., Nishimura, W., Ohnishi, H., Mashima, H., Fujita, T., Omata, M., Hata, Y. Oncogene (2003) [Pubmed]
  9. Roles of immunoglobulin-like loops of junctional cell adhesion molecule 4; involvement in the subcellular localization and the cell adhesion. Tajima, M., Hirabayashi, S., Yao, I., Shirasawa, M., Osuga, J., Ishibashi, S., Fujita, T., Hata, Y. Genes Cells (2003) [Pubmed]
  10. Altered expression of junctional adhesion molecule 4 in injured podocytes. Harita, Y., Miyauchi, N., Karasawa, T., Suzuki, K., Han, G.D., Koike, H., Igarashi, T., Shimizu, F., Kawachi, H. Am. J. Physiol. Renal Physiol. (2006) [Pubmed]
  11. Tight junction protein MAGI-1 is up-regulated by transfection with connexin 32 in an immortalized mouse hepatic cell line: cDNA microarray analysis. Murata, M., Kojima, T., Yamamoto, T., Go, M., Takano, K., Chiba, H., Tokino, T., Sawada, N. Cell Tissue Res. (2005) [Pubmed]
  12. The membrane-associated guanylate kinase protein MAGI-1 binds megalin and is present in glomerular podocytes. Patrie, K.M., Drescher, A.J., Goyal, M., Wiggins, R.C., Margolis, B. J. Am. Soc. Nephrol. (2001) [Pubmed]
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