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Gene Review

NR1I3  -  nuclear receptor subfamily 1, group I,...

Homo sapiens

Synonyms: CAR, CAR1, Constitutive activator of retinoid response, Constitutive active response, Constitutive androstane receptor, ...
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Disease relevance of NR1I3


High impact information on NR1I3


Biological context of NR1I3


Anatomical context of NR1I3


Associations of NR1I3 with chemical compounds


Physical interactions of NR1I3


Regulatory relationships of NR1I3


Other interactions of NR1I3


Analytical, diagnostic and therapeutic context of NR1I3

  • Screening by nested PCR specific to the coral-associated Rickettsiales 1 (CAR1) bacterium showed that this microbe was widespread in both healthy and diseased A. cervicornis and A. palmata corals from 'healthy' (i.e. low WBD I incidence) and 'stressed' reefs (i.e. high WBD I incidence) [26].


  1. The Pichia pastoris PER6 gene product is a peroxisomal integral membrane protein essential for peroxisome biogenesis and has sequence similarity to the Zellweger syndrome protein PAF-1. Waterham, H.R., de Vries, Y., Russel, K.A., Xie, W., Veenhuis, M., Cregg, J.M. Mol. Cell. Biol. (1996) [Pubmed]
  2. Xenobiotic stress induces hepatomegaly and liver tumors via the nuclear receptor constitutive androstane receptor. Huang, W., Zhang, J., Washington, M., Liu, J., Parant, J.M., Lozano, G., Moore, D.D. Mol. Endocrinol. (2005) [Pubmed]
  3. Conservation of signaling pathways of xenobiotic-sensing orphan nuclear receptors, chicken xenobiotic receptor, constitutive androstane receptor, and pregnane X receptor, from birds to humans. Handschin, C., Podvinec, M., Stöckli, J., Hoffmann, K., Meyer, U.A. Mol. Endocrinol. (2001) [Pubmed]
  4. Down-regulation of astroglial CYP2C, glucocorticoid receptor and constitutive androstane receptor genes in response to cocaine in human U373 MG astrocytoma cells. Malaplate-Armand, C., Ferrari, L., Masson, C., Visvikis-Siest, S., Lambert, H., Batt, A.M. Toxicol. Lett. (2005) [Pubmed]
  5. Improved gene delivery to B lymphocytes using a modified adenovirus vector targeting CD21. Mailly, L., Renaut, L., Rogée, S., Grellier, E., D'Halluin, J.C., Colin, M. Mol. Ther. (2006) [Pubmed]
  6. International Union of Pharmacology. LXII. The NR1H and NR1I Receptors: Constitutive Androstane Receptor, Pregnene X Receptor, Farnesoid X Receptor {alpha}, Farnesoid X Receptor beta, Liver X Receptor {alpha}, Liver X Receptor beta, and Vitamin D Receptor. Moore, D.D., Kato, S., Xie, W., Mangelsdorf, D.J., Schmidt, D.R., Xiao, R., Kliewer, S.A. Pharmacol. Rev. (2006) [Pubmed]
  7. A structural basis for constitutive activity in the human CAR/RXRalpha heterodimer. Xu, R.X., Lambert, M.H., Wisely, B.B., Warren, E.N., Weinert, E.E., Waitt, G.M., Williams, J.D., Collins, J.L., Moore, L.B., Willson, T.M., Moore, J.T. Mol. Cell (2004) [Pubmed]
  8. A traditional herbal medicine enhances bilirubin clearance by activating the nuclear receptor CAR. Huang, W., Zhang, J., Moore, D.D. J. Clin. Invest. (2004) [Pubmed]
  9. CAR-1 and Trailer hitch: driving mRNP granule function at the ER? Decker, C.J., Parker, R. J. Cell Biol. (2006) [Pubmed]
  10. In the regulation of cytochrome P450 genes, phenobarbital targets LKB1 for necessary activation of AMP-activated protein kinase. Blättler, S.M., Rencurel, F., Kaufmann, M.R., Meyer, U.A. Proc. Natl. Acad. Sci. U.S.A. (2007) [Pubmed]
  11. Retinoid X receptor-alpha-dependent transactivation by a naturally occurring structural variant of human constitutive androstane receptor (NR1I3). Auerbach, S.S., Stoner, M.A., Su, S., Omiecinski, C.J. Mol. Pharmacol. (2005) [Pubmed]
  12. Relative Activation of Human Pregnane X Receptor versus Constitutive Androstane Receptor Defines Distinct Classes of CYP2B6 and CYP3A4 Inducers. Faucette, S.R., Zhang, T.C., Moore, R., Sueyoshi, T., Omiecinski, C.J., Lecluyse, E.L., Negishi, M., Wang, H. J. Pharmacol. Exp. Ther. (2007) [Pubmed]
  13. Differential regulation of hepatic CYP2B6 and CYP3A4 genes by constitutive androstane receptor but not pregnane X receptor. Faucette, S.R., Sueyoshi, T., Smith, C.M., Negishi, M., Lecluyse, E.L., Wang, H. J. Pharmacol. Exp. Ther. (2006) [Pubmed]
  14. Transcriptional analysis of the orphan nuclear receptor constitutive androstane receptor (NR1I3) gene promoter: identification of a distal glucocorticoid response element. Pascussi, J.M., Busson-Le Coniat, M., Maurel, P., Vilarem, M.J. Mol. Endocrinol. (2003) [Pubmed]
  15. Dexamethasone enhances constitutive androstane receptor expression in human hepatocytes: consequences on cytochrome P450 gene regulation. Pascussi, J.M., Gerbal-Chaloin, S., Fabre, J.M., Maurel, P., Vilarem, M.J. Mol. Pharmacol. (2000) [Pubmed]
  16. Tissue-specific mRNA expression profiles of human nuclear receptor subfamilies. Nishimura, M., Naito, S., Yokoi, T. Drug Metab. Pharmacokinet. (2004) [Pubmed]
  17. Di-n-butyl phthalate activates constitutive androstane receptor and pregnane X receptor and enhances the expression of steroid-metabolizing enzymes in the liver of rat fetuses. Wyde, M.E., Kirwan, S.E., Zhang, F., Laughter, A., Hoffman, H.B., Bartolucci-Page, E., Gaido, K.W., Yan, B., You, L. Toxicol. Sci. (2005) [Pubmed]
  18. Absorption properties and P-glycoprotein activity of modified Caco-2 cell lines. Korjamo, T., Honkakoski, P., Toppinen, M.R., Niva, S., Reinisalo, M., Palmgrén, J.J., Mönkkönen, J. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. (2005) [Pubmed]
  19. Identification of a cellular receptor for subgroup E avian leukosis virus. Adkins, H.B., Brojatsch, J., Naughton, J., Rolls, M.M., Pesola, J.M., Young, J.A. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  20. Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands. Moore, L.B., Parks, D.J., Jones, S.A., Bledsoe, R.K., Consler, T.G., Stimmel, J.B., Goodwin, B., Liddle, C., Blanchard, S.G., Willson, T.M., Collins, J.L., Kliewer, S.A. J. Biol. Chem. (2000) [Pubmed]
  21. A new orphan member of the nuclear hormone receptor superfamily that interacts with a subset of retinoic acid response elements. Baes, M., Gulick, T., Choi, H.S., Martinoli, M.G., Simha, D., Moore, D.D. Mol. Cell. Biol. (1994) [Pubmed]
  22. Identification of constitutive androstane receptor and glucocorticoid receptor binding sites in the CYP2C19 promoter. Chen, Y., Ferguson, S.S., Negishi, M., Goldstein, J.A. Mol. Pharmacol. (2003) [Pubmed]
  23. Transcriptional regulation of human UGT1A1 gene expression: activated glucocorticoid receptor enhances constitutive androstane receptor/pregnane X receptor-mediated UDP-glucuronosyltransferase 1A1 regulation with glucocorticoid receptor-interacting protein 1. Sugatani, J., Nishitani, S., Yamakawa, K., Yoshinari, K., Sueyoshi, T., Negishi, M., Miwa, M. Mol. Pharmacol. (2005) [Pubmed]
  24. Ketoconazole and miconazole are antagonists of the human glucocorticoid receptor: consequences on the expression and function of the constitutive androstane receptor and the pregnane X receptor. Duret, C., Daujat-Chavanieu, M., Pascussi, J.M., Pichard-Garcia, L., Balaguer, P., Fabre, J.M., Vilarem, M.J., Maurel, P., Gerbal-Chaloin, S. Mol. Pharmacol. (2006) [Pubmed]
  25. Transcriptional regulation of CYP2C9 gene. Role of glucocorticoid receptor and constitutive androstane receptor. Gerbal-Chaloin, S., Daujat, M., Pascussi, J.M., Pichard-Garcia, L., Vilarem, M.J., Maurel, P. J. Biol. Chem. (2002) [Pubmed]
  26. Widespread association of a Rickettsiales-like bacterium with reef-building corals. Casas, V., Kline, D.I., Wegley, L., Yu, Y., Breitbart, M., Rohwer, F. Environ. Microbiol. (2004) [Pubmed]
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