Gene Review:
CYP2J2 - cytochrome P450, family 2, subfamily J,...
Homo sapiens
Synonyms:
Arachidonic acid epoxygenase, CYPIIJ2, Cytochrome P450 2J2
- Characterization of rat and human CYP2J enzymes as Vitamin D 25-hydroxylases. Aiba, I., Yamasaki, T., Shinki, T., Izumi, S., Yamamoto, K., Yamada, S., Terato, H., Ide, H., Ohyama, Y. Steroids (2006)
- Single nucleotide polymorphisms in the CYP2J2 and CYP2C8 genes and the risk of hypertension. King, L.M., Gainer, J.V., David, G.L., Dai, D., Goldstein, J.A., Brown, N.J., Zeldin, D.C. Pharmacogenet. Genomics (2005)
- Molecular cloning and expression of CYP2J2, a human cytochrome P450 arachidonic acid epoxygenase highly expressed in heart. Wu, S., Moomaw, C.R., Tomer, K.B., Falck, J.R., Zeldin, D.C. J. Biol. Chem. (1996)
- Role of activator protein-1 in the down-regulation of the human CYP2J2 gene in hypoxia. Marden, N.Y., Fiala-Beer, E., Xiang, S.H., Murray, M. Biochem. J. (2003)
- Enhanced postischemic functional recovery in CYP2J2 transgenic hearts involves mitochondrial ATP-sensitive K+ channels and p42/p44 MAPK pathway. Seubert, J., Yang, B., Bradbury, J.A., Graves, J., Degraff, L.M., Gabel, S., Gooch, R., Foley, J., Newman, J., Mao, L., Rockman, H.A., Hammock, B.D., Murphy, E., Zeldin, D.C. Circ. Res. (2004)
- Variability of CYP2J2 Expression in Human Fetal Tissues. Gaedigk, A., Baker, D.W., Totah, R.A., Gaedigk, R., Pearce, R.E., Vyhlidal, C.A., Zeldin, D.C., Leeder, J.S. J. Pharmacol. Exp. Ther. (2006)
- Anti-inflammatory properties of cytochrome P450 epoxygenase-derived eicosanoids. Node, K., Huo, Y., Ruan, X., Yang, B., Spiecker, M., Ley, K., Zeldin, D.C., Liao, J.K. Science (1999)
- Cytochrome P450 2J2 promotes the neoplastic phenotype of carcinoma cells and is up-regulated in human tumors. Jiang, J.G., Chen, C.L., Card, J.W., Yang, S., Chen, J.X., Fu, X.N., Ning, Y.G., Xiao, X., Zeldin, D.C., Wang, D.W. Cancer Res. (2005)
- Activation of Galpha s mediates induction of tissue-type plasminogen activator gene transcription by epoxyeicosatrienoic acids. Node, K., Ruan, X.L., Dai, J., Yang, S.X., Graham, L., Zeldin, D.C., Liao, J.K. J. Biol. Chem. (2001)
- Characterization of Ebastine, Hydroxyebastine, and Carebastine Metabolism by Human Liver Microsomes and Expressed Cytochrome P450 Enzymes: Major Roles for CYP2J2 and CYP3A. Liu, K.H., Kim, M.G., Lee, D.J., Yoon, Y.J., Kim, M.J., Shon, J.H., Choi, C.S., Choi, Y.K., Desta, Z., Shin, J.G. Drug Metab. Dispos. (2006)
- Molecular cloning, expression, and functional significance of a cytochrome P450 highly expressed in rat heart myocytes. Wu, S., Chen, W., Murphy, E., Gabel, S., Tomer, K.B., Foley, J., Steenbergen, C., Falck, J.R., Moomaw, C.R., Zeldin, D.C. J. Biol. Chem. (1997)
- Overexpression of cytochrome P450 CYP2J2 protects against hypoxia-reoxygenation injury in cultured bovine aortic endothelial cells. Yang, B., Graham, L., Dikalov, S., Mason, R.P., Falck, J.R., Liao, J.K., Zeldin, D.C. Mol. Pharmacol. (2001)
- Involvement of CYP2J2 and CYP4F12 in the metabolism of ebastine in human intestinal microsomes. Hashizume, T., Imaoka, S., Mise, M., Terauchi, Y., Fujii, T., Miyazaki, H., Kamataki, T., Funae, Y. J. Pharmacol. Exp. Ther. (2002)
- Detection of Human CYP2C8, CYP2C9, and CYP2J2 in Cardiovascular Tissues. Delozier, T.C., Kissling, G.E., Coulter, S.J., Dai, D., Foley, J.F., Bradbury, J.A., Murphy, E., Steenbergen, C., Zeldin, D.C., Goldstein, J.A. Drug Metab. Dispos. (2007)
- Cytochrome P450 CYP2J9, a new mouse arachidonic acid omega-1 hydroxylase predominantly expressed in brain. Qu, W., Bradbury, J.A., Tsao, C.C., Maronpot, R., Harry, G.J., Parker, C.E., Davis, L.S., Breyer, M.D., Waalkes, M.P., Falck, J.R., Chen, J., Rosenberg, R.L., Zeldin, D.C. J. Biol. Chem. (2001)
- CYP2J subfamily cytochrome P450s in the gastrointestinal tract: expression, localization, and potential functional significance. Zeldin, D.C., Foley, J., Goldsworthy, S.M., Cook, M.E., Boyle, J.E., Ma, J., Moomaw, C.R., Tomer, K.B., Steenbergen, C., Wu, S. Mol. Pharmacol. (1997)
- Arachidonic acid metabolism by human cytochrome P450s 2C8, 2C9, 2E1, and 1A2: regioselective oxygenation and evidence for a role for CYP2C enzymes in arachidonic acid epoxygenation in human liver microsomes. Rifkind, A.B., Lee, C., Chang, T.K., Waxman, D.J. Arch. Biochem. Biophys. (1995)
- CYP2J subfamily P450s in the lung: expression, localization, and potential functional significance. Zeldin, D.C., Foley, J., Ma, J., Boyle, J.E., Pascual, J.M., Moomaw, C.R., Tomer, K.B., Steenbergen, C., Wu, S. Mol. Pharmacol. (1996)
- Cloning of CYP2J2 gene and identification of functional polymorphisms. King, L.M., Ma, J., Srettabunjong, S., Graves, J., Bradbury, J.A., Li, L., Spiecker, M., Liao, J.K., Mohrenweiser, H., Zeldin, D.C. Mol. Pharmacol. (2002)
- Identification and functional characterization of novel CYP2J2 variants: G312R variant causes loss of enzyme catalytic activity. Lee, S.S., Jeong, H.E., Liu, K.H., Ryu, J.Y., Moon, T., Yoon, C.N., Oh, S.J., Yun, C.H., Shin, J.G. Pharmacogenet. Genomics (2005)
- Expression of biotransformation enzymes in human fetal olfactory mucosa: potential roles in developmental toxicity. Gu, J., Su, T., Chen, Y., Zhang, Q.Y., Ding, X. Toxicol. Appl. Pharmacol. (2000)
- Cardiac and vascular KATP channels in rats are activated by endogenous epoxyeicosatrienoic acids through different mechanisms. Lu, T., Ye, D., Wang, X., Seubert, J.M., Graves, J.P., Bradbury, J.A., Zeldin, D.C., Lee, H.C. J. Physiol. (Lond.) (2006)