The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Glmn  -  glomulin, FKBP associated protein

Mus musculus

Synonyms: 9330160J16Rik, AW227515, FAP, FK506-binding protein-associated protein, FKBP-associated protein, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Glmn

  • Human FAP is selectively expressed by tumor stromal fibroblasts in epithelial carcinomas, but not by epithelial carcinoma cells, normal fibroblasts, or other normal tissues [1].
  • Both s.c. implanted tumors and lung metastases were susceptible to anti-FAP immunotherapy [2].
  • Using melanoma, carcinoma, and lymphoma models, we show that tumor growth was inhibited in tumor-bearing mice vaccinated against FAP and that the magnitude of the antitumor response was comparable to that of vaccination against tumor cell-expressed antigens [2].
  • In accordance with a strict target-selective activity of sc40-FasL, the intravenous application of this reagent in mice revealed no signs of systemic toxicity and prevented growth of xenotransplanted FAP-positive (but not FAP-negative) tumor cells [3].
  • The primary objective of this study was to evaluate the clinical significance of stromal FAP in human colon cancers by immunohistochemisty [4].

High impact information on Glmn


Biological context of Glmn


Anatomical context of Glmn


Associations of Glmn with chemical compounds

  • Mutation of the putative catalytic serine residue of FAP to alanine abolishes both enzymatic activities [11].
  • We examined the age-dependent susceptibility to azoxymethane (AOM)-induced and spontaneous tumorigenesis in the Min/+ mouse, a murine FAP model [13].
  • One of the fractions, FAP (fraction from apple polyphenol) 1, which contains non-catechin polyphenols, did not significantly inhibit the CT-catalyzed ADP-ribosylation of agmatine [14].
  • The model was subsequently used to evaluate the biodistribution properties of an iodine-131-labeled humanized anti-FAP monoclonal antibody (BIBH-7) [12].
  • Doxycycline disrupts transthyretin amyloid: evidence from studies in a FAP transgenic mice model [15].

Analytical, diagnostic and therapeutic context of Glmn

  • We studied glomulin expression during murine development (E9.5 days post-coitum until adulthood) by non-radioactive in situ hybridization [6].
  • HT-29 xenografts treated with these inhibitory anti-FAP antisera exhibited attenuated growth compared with tumors treated with preimmunization rabbit antisera [1].
  • These data demonstrate the ability of FAP to potentiate tumor growth in an animal model [1].
  • These data warrant transfer of the anti-FAP-TNF immunocytokine into clinical trials for the treatment of FAP-positive tumors [16].
  • Consistent with its in vivo expression pattern determined by immunohistochemistry, FAP enzyme activity was detected by an immunocapture assay in human cancerous tissues but not in matched normal tissues [11].


  1. Promotion of tumor growth by murine fibroblast activation protein, a serine protease, in an animal model. Cheng, J.D., Dunbrack, R.L., Valianou, M., Rogatko, A., Alpaugh, R.K., Weiner, L.M. Cancer Res. (2002) [Pubmed]
  2. Tumor immunotherapy targeting fibroblast activation protein, a product expressed in tumor-associated fibroblasts. Lee, J., Fassnacht, M., Nair, S., Boczkowski, D., Gilboa, E. Cancer Res. (2005) [Pubmed]
  3. Generation of a FasL-based proapoptotic fusion protein devoid of systemic toxicity due to cell-surface antigen-restricted Activation. Samel, D., Muller, D., Gerspach, J., Assohou-Luty, C., Sass, G., Tiegs, G., Pfizenmaier, K., Wajant, H. J. Biol. Chem. (2003) [Pubmed]
  4. Clinical implications of fibroblast activation protein in patients with colon cancer. Henry, L.R., Lee, H.O., Lee, J.S., Klein-Szanto, A., Watts, P., Ross, E.A., Chen, W.T., Cheng, J.D. Clin. Cancer Res. (2007) [Pubmed]
  5. Targeting tumor-associated fibroblasts improves cancer chemotherapy by increasing intratumoral drug uptake. Loeffler, M., Krüger, J.A., Niethammer, A.G., Reisfeld, R.A. J. Clin. Invest. (2006) [Pubmed]
  6. Glomulin is predominantly expressed in vascular smooth muscle cells in the embryonic and adult mouse. McIntyre, B.A., Brouillard, P., Aerts, V., Gutierrez-Roelens, I., Vikkula, M. Gene Expr. Patterns (2004) [Pubmed]
  7. Role of a bacillus Calmette-Guérin fibronectin attachment protein in BCG-induced antitumor activity. Zhao, W., Schorey, J.S., Bong-Mastek, M., Ritchey, J., Brown, E.J., Ratliff, T.L. Int. J. Cancer (2000) [Pubmed]
  8. Connexin43 is overexpressed in Apc(Min/+)-mice adenomas and colocalises with COX-2 in myofibroblasts. Husøy, T., Knutsen, H.K., Cruciani, V., Olstørn, H.B., Mikalsen, S.O., Løberg, E.M., Alexander, J. Int. J. Cancer (2005) [Pubmed]
  9. Activation of c-fos expression by transforming Ha-ras in HC11 mouse mammary epithelial cells is PKC-dependent and mediated by the serum response element. Uberall, F., Kampfer, S., Doppler, W., Grunicke, H.H. Cell. Signal. (1994) [Pubmed]
  10. Fibroblast activation protein (FAP) is upregulated in myelomatous bone and supports myeloma cell survival. Ge, Y., Zhan, F., Barlogie, B., Epstein, J., Shaughnessy, J., Yaccoby, S. Br. J. Haematol. (2006) [Pubmed]
  11. Fibroblast activation protein, a dual specificity serine protease expressed in reactive human tumor stromal fibroblasts. Park, J.E., Lenter, M.C., Zimmermann, R.N., Garin-Chesa, P., Old, L.J., Rettig, W.J. J. Biol. Chem. (1999) [Pubmed]
  12. Expression and targeting of human fibroblast activation protein in a human skin/severe combined immunodeficient mouse breast cancer xenograft model. Tahtis, K., Lee, F.T., Wheatley, J.M., Garin-Chesa, P., Park, J.E., Smyth, F.E., Obata, Y., Stockert, E., Hall, C.M., Old, L.J., Rettig, W.J., Scott, A.M. Mol. Cancer Ther. (2003) [Pubmed]
  13. Age-dependent susceptibility to azoxymethane-induced and spontaneous tumorigenesis in the Min/+ mouse. Paulsen, J.E., Steffensen, I.L., Namork, E., Eide, T.J., Alexander, J. Anticancer Res. (2003) [Pubmed]
  14. Inhibition by apple polyphenols of ADP-ribosyltransferase activity of cholera toxin and toxin-induced fluid accumulation in mice. Saito, T., Miyake, M., Toba, M., Okamatsu, H., Shimizu, S., Noda, M. Microbiol. Immunol. (2002) [Pubmed]
  15. Doxycycline disrupts transthyretin amyloid: evidence from studies in a FAP transgenic mice model. Cardoso, I., Saraiva, M.J. FASEB J. (2006) [Pubmed]
  16. Targeted bioactivity of membrane-anchored TNF by an antibody-derived TNF fusion protein. Bauer, S., Adrian, N., Williamson, B., Panousis, C., Fadle, N., Smerd, J., Fettah, I., Scott, A.M., Pfreundschuh, M., Renner, C. J. Immunol. (2004) [Pubmed]
WikiGenes - Universities