Gene Review:
Havcr2 - hepatitis A virus cellular receptor 2
Mus musculus
Synonyms:
HAVcr-2, Hepatitis A virus cellular receptor 2 homolog, T-cell immunoglobulin and mucin domain-containing protein 3, T-cell immunoglobulin mucin receptor 3, T-cell membrane protein 3, ...
- Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease. Monney, L., Sabatos, C.A., Gaglia, J.L., Ryu, A., Waldner, H., Chernova, T., Manning, S., Greenfield, E.A., Coyle, A.J., Sobel, R.A., Freeman, G.J., Kuchroo, V.K. Nature (2002)
- Dysregulated T cell expression of TIM3 in multiple sclerosis. Koguchi, K., Anderson, D.E., Yang, L., O'Connor, K.C., Kuchroo, V.K., Hafler, D.A. J. Exp. Med. (2006)
- T Cell Ig- and mucin-domain-containing molecule-3 (TIM-3) and TIM-1 molecules are differentially expressed on human Th1 and Th2 cells and in cerebrospinal fluid-derived mononuclear cells in multiple sclerosis. Khademi, M., Illés, Z., Gielen, A.W., Marta, M., Takazawa, N., Baecher-Allan, C., Brundin, L., Hannerz, J., Martin, C., Harris, R.A., Hafler, D.A., Kuchroo, V.K., Olsson, T., Piehl, F., Wallström, E. J. Immunol. (2004)
- Preferential Involvement of Tim-3 in the Regulation of Hepatic CD8+ T Cells in Murine Acute Graft-versus-Host Disease. Oikawa, T., Kamimura, Y., Akiba, H., Yagita, H., Okumura, K., Takahashi, H., Zeniya, M., Tajiri, H., Azuma, M. J. Immunol. (2006)
- Cutting edge: T cell Ig mucin-3 reduces inflammatory heart disease by increasing CTLA-4 during innate immunity. Frisancho-Kiss, S., Nyland, J.F., Davis, S.E., Barrett, M.A., Gatewood, S.J., Njoku, D.B., Cihakova, D., Silbergeld, E.K., Rose, N.R., Fairweather, D. J. Immunol. (2006)
- Th2-driven, allergen-induced airway inflammation is reduced after treatment with anti-Tim-3 antibody in vivo. Kearley, J., McMillan, S.J., Lloyd, C.M. J. Exp. Med. (2007)
- TIM Family of Genes in Immunity and Tolerance. Kuchroo, V.K., Meyers, J.H., Umetsu, D.T., Dekruyff, R.H. Adv. Immunol. (2006)
- Interaction of Tim-3 and Tim-3 ligand regulates T helper type 1 responses and induction of peripheral tolerance. Sabatos, C.A., Chakravarti, S., Cha, E., Schubart, A., Sánchez-Fueyo, A., Zheng, X.X., Coyle, A.J., Strom, T.B., Freeman, G.J., Kuchroo, V.K. Nat. Immunol. (2003)
- Genetic analysis of the influence of neuroantigen-complete Freund's adjuvant emulsion structures on the sexual dimorphism and susceptibility to experimental allergic encephalomyelitis. Fillmore, P.D., Brace, M., Troutman, S.A., Blankenhorn, E.P., Diehl, S., Rincon, M., Teuscher, C. Am. J. Pathol. (2003)
- Human membrane protein Tim-3 facilitates hepatitis A virus entry into target cells. Sui, L., Zhang, W., Chen, Y., Zheng, Y., Wan, T., Zhang, W., Yang, Y., Fang, G., Mao, J., Cao, X. Int. J. Mol. Med. (2006)
- Expression of Tim-3 is transiently increased before development of anterior chamber-associated immune deviation. Wang, Y., Yang, P., Li, B., Zhou, H., Huang, X., Wang, Y., Chi, W., Zhu, X., Zhu, L., Kijlstra, A. Ocul. Immunol. Inflamm. (2006)
- Tim-3 inhibits T helper type 1-mediated auto- and alloimmune responses and promotes immunological tolerance. Sánchez-Fueyo, A., Tian, J., Picarella, D., Domenig, C., Zheng, X.X., Sabatos, C.A., Manlongat, N., Bender, O., Kamradt, T., Kuchroo, V.K., Gutiérrez-Ramos, J.C., Coyle, A.J., Strom, T.B. Nat. Immunol. (2003)
- Ccr5 but not Ccr1 deficiency reduces development of diet-induced atherosclerosis in mice. Braunersreuther, V., Zernecke, A., Arnaud, C., Liehn, E.A., Steffens, S., Shagdarsuren, E., Bidzhekov, K., Burger, F., Pelli, G., Luckow, B., Mach, F., Weber, C. Arterioscler. Thromb. Vasc. Biol. (2007)