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Gene Review

Ogn  -  osteoglycin

Mus musculus

Synonyms: 3110079A16Rik, Mimecan, OG, OIF, Og, ...
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Disease relevance of Ogn

  • OBJECTIVE: We hypothesize that the mimecan gene expressed in the human pituitary and regulated by pituitary transcription factor-1 (Pit-1) might act as a marker for diagnosing pituitary tumors [1].

High impact information on Ogn


Biological context of Ogn

  • In this study, we have isolated from a mouse limb-bud library cDNA clones encoding a 298-aa OG [4].
  • Microarray hybridization was used to determine gene expression differences between lenses isolated from mimecan-null and wild type mice [5].
  • The 177 base pair DNA coding for this unique sequence shows 47% identity to an 189 base pair sequence between exons 4 and 5 of the bovine osteoglycin/mimecan gene [6].
  • Recently we demonstrated the presence of eight mimecan mRNA transcripts generated by alternative transcription initiation, alternative polyadenylation, and differential splicing, all of which encode an identical protein [7].
  • These results suggest that the increased expression of the osteoglycin gene by LLLI in the early proliferation stage of cultured osteoblastic cells may play an important role in the stimulation of bone formation in concert with matrix proteins and growth factors [8].

Anatomical context of Ogn

  • RESULTS: The mean collagen fibril diameter in the corneas of mimecan-null mice, as an average throughout the whole thickness of the tissue, was not appreciably different from normal (35.6 +/- 1.1 nm vs. 35.9 +/- 1.0 nm) [3].
  • This study was performed to investigate the fibrillar architecture of the corneal stroma in mice homozygous for a null mutation in the corneal KSPG, mimecan [3].
  • Mimecan is a member of this gene family and is expressed in many connective tissues [5].
  • Effect of low-level laser irradiation on osteoglycin gene expression in osteoblasts [8].
  • As the OIFs of the parietal and frontal bones approach, but prior to any physical overlap, they lie in different planes dorsoventrally; the parietal OIF located dorsal to the frontal OIF, a pattern maintained throughout subsequent sutural morphogenesis [9].

Associations of Ogn with chemical compounds

  • The deduced amino acid (aa) sequence from the cDNA analysis showed that a precursor of OG has consensus leucine-rich repeats [4].
  • Osteoglycin (OG) is a glycoprotein that was first isolated from bovine bone [4].

Regulatory relationships of Ogn


Other interactions of Ogn

  • The validity of the microarray data was established with the increased expression of bone-related genes such as pleiotrophin, osteoglycin, and legumain upon four-point bending and confirmation of increased expression of selected genes by real-time PCR [10].
  • Osteoglycin is a small leucine-rich proteoglycan (SLRP) of the extracellular matrix which was previously called the osteoinductive factor [8].

Analytical, diagnostic and therapeutic context of Ogn


  1. The mimecan gene expressed in human pituitary and regulated by pituitary transcription factor-1 as a marker for diagnosing pituitary tumors. Hu, S.M., Li, F., Yu, H.M., Li, R.Y., Ma, Q.Y., Ye, T.J., Lu, Z.Y., Chen, J.L., Song, H.D. J. Clin. Endocrinol. Metab. (2005) [Pubmed]
  2. Bone morphogenetic protein-1/tolloid-related metalloproteinases process osteoglycin and enhance its ability to regulate collagen fibrillogenesis. Ge, G., Seo, N.S., Liang, X., Hopkins, D.R., Höök, M., Greenspan, D.S. J. Biol. Chem. (2004) [Pubmed]
  3. An x-ray diffraction study of corneal structure in mimecan-deficient mice. Beecher, N., Carlson, C., Allen, B.R., Kipchumba, R., Conrad, G.W., Meek, K.M., Quantock, A.J. Invest. Ophthalmol. Vis. Sci. (2005) [Pubmed]
  4. Molecular cloning of the mouse osteoglycin-encoding gene. Ujita, M., Shinomura, T., Kimata, K. Gene (1995) [Pubmed]
  5. Differentially expressed genes in the lens of mimecan-null mice. Tasheva, E.S., Ke, A., Deng, Y., Jun, C., Takemoto, L.J., Koester, A., Conrad, G.W. Mol. Vis. (2004) [Pubmed]
  6. Expression of the keratan sulfate proteoglycans lumican, keratocan and osteoglycin/mimecan during chick corneal development. Dunlevy, J.R., Beales, M.P., Berryhill, B.L., Cornuet, P.K., Hassell, J.R. Exp. Eye Res. (2000) [Pubmed]
  7. Transcriptional activation of bovine mimecan by p53 through an intronic DNA-binding site. Tasheva, E.S., Maki, C.G., Conrad, A.H., Conrad, G.W. Biochim. Biophys. Acta (2001) [Pubmed]
  8. Effect of low-level laser irradiation on osteoglycin gene expression in osteoblasts. Hamajima, S., Hiratsuka, K., Kiyama-Kishikawa, M., Tagawa, T., Kawahara, M., Ohta, M., Sasahara, H., Abiko, Y. Lasers in medical science. (2003) [Pubmed]
  9. Morphogenesis of the mouse coronal suture. Johansen, V.A., Hall, S.H. Acta anatomica. (1982) [Pubmed]
  10. Global gene expression analysis in the bones reveals involvement of several novel genes and pathways in mediating an anabolic response of mechanical loading in mice. Xing, W., Baylink, D., Kesavan, C., Hu, Y., Kapoor, S., Chadwick, R.B., Mohan, S. J. Cell. Biochem. (2005) [Pubmed]
  11. Mimecan/osteoglycin-deficient mice have collagen fibril abnormalities. Tasheva, E.S., Koester, A., Paulsen, A.Q., Garrett, A.S., Boyle, D.L., Davidson, H.J., Song, M., Fox, N., Conrad, G.W. Mol. Vis. (2002) [Pubmed]
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