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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Frontal Bone

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Disease relevance of Frontal Bone


High impact information on Frontal Bone

  • However, this requirement is restricted to the developing calvarial aspect of the frontal bone, whereas the orbital aspect forms despite the ablation of Tgfbr2 gene, implying a differential requirement for TGFbeta signaling during the development of various regions of the frontal bone [6].
  • Both the quantity and proliferation of the frontal bone skeletogenic mesenchyme are reduced in Msx2-Twist double mutants compared with individual mutants [7].
  • In contrast, no significant difference was found in extent of lysine hydroxylation of the collagens of frontal bones of embryos and postnatal animals [8].
  • Exposure of embryos to retinoic acid at E10.0 reduces this meningeal neural crest and inhibits parietal ossification, suggesting that intramembranous ossification of this mesodermal bone requires interaction with neural crest-derived meninges, whereas ossification of the neural crest-derived frontal bone is autonomous [9].
  • Pedicles and antlers originate from a specialized region of the frontal bone; the 'antlerogeneic periosteum' and the systemic cue which triggers their development in the fawn is an increase in circulating androgen [10].

Chemical compound and disease context of Frontal Bone

  • Treatment of some sinus diseases can be enhanced by access through direct sinus endoscopy for focal lesions, use of large frontal bone flaps for diffuse sinus lesions, standing surgery through a frontal flap for a variety of sinus disorders, and intralesional formalin for progressive ethmoidal hematomas [11].

Biological context of Frontal Bone

  • As the OIFs of the parietal and frontal bones approach, but prior to any physical overlap, they lie in different planes dorsoventrally; the parietal OIF located dorsal to the frontal OIF, a pattern maintained throughout subsequent sutural morphogenesis [12].

Anatomical context of Frontal Bone


Associations of Frontal Bone with chemical compounds

  • In frontal bone and cartilage, [3H] hydroxyproline content was decreased 88% and 57%, respectively, and [3H]proline content was decreased 68% and 37%, respectively; neither was affected in the aorta [17].
  • Amalgam markers were placed in the parietal and frontal bones across the coronal suture, and were measured immediately after surgery and at the time of sacrifice to confirm mechanical immobility [18].
  • CLINICAL PRESENTATION: Hydroxyapatite cement was used for reconstruction of a frontal bone defect secondary to a traumatic depressed cranial fracture in a 9-year-old male patient [19].
  • Two radiopaque implants were inserted into each (left and right) frontal bone in five female rabbits [20].
  • Twenty-eight tricalcium phosphate implants (15 mm diameter x 5 mm; pore size, 100-200 microns) were divided into experimental and control groups and placed on the frontal bone of 14 adult New Zealand White rabbits [21].

Gene context of Frontal Bone

  • Here, we show that TGFbeta IIR is required for proliferation of osteoprogenitor cells in the CNC-derived frontal bone anlagen [6].
  • He also has a defect of the anterior midline scalp with involvement of the frontal bone as documented by a computed tomography (CT) scan [22].
  • The clinical diagnosis of HCC was made because of the presence of a liver mass on abdominal computed tomography (CT) scan, high serum alpha-fetoprotein value and tissue diagnosis on frontal bone biopsy [23].
  • The olfactory aspect of the frontal bone bulged slightly outwards, medial walls of orbits were laterally displaced, parietal and interparietal showed distention and their related sagittal and coronal sutures unfused and open to 1 mm in places [24].

Analytical, diagnostic and therapeutic context of Frontal Bone


  1. Thallium-201 uptake in eosinophilic granuloma of the frontal bone: comparison with technetium-99m-MDP imaging. Flores, L.G., Hoshi, H., Nagamachi, S., Ohnishi, T., Watanabe, K., Fukiyama, J., Nao-i, N., Sawada, A. J. Nucl. Med. (1995) [Pubmed]
  2. Intraosseous hemangioma of the skull with dural tail sign: radiologic features with pathologic correlation. Politi, M., Romeike, B.F., Papanagiotou, P., Nabhan, A., Struffert, T., Feiden, W., Reith, W. AJNR. American journal of neuroradiology. (2005) [Pubmed]
  3. Cholesterol granuloma of the frontal bone: CT diagnosis. Eijpe, A.A., Koornneef, L., Verbeeten, B., Peeters, F.L., Zonneveld, F.W. Journal of computer assisted tomography. (1990) [Pubmed]
  4. Fronto-nasal dysplasia and lipoma of the corpus callosum. Pascual-Castroviejo, I., Pascual-Pascual, S.I., Pérez-Higueras, A. Eur. J. Pediatr. (1985) [Pubmed]
  5. Scaphocephaly: premature closure of the sagittal suture: a localized disorder of cellular metabolism? Pensler, J.M., Ivescu, A.S., Radosevich, J.A. Annals of plastic surgery. (1998) [Pubmed]
  6. TGFbeta-mediated FGF signaling is crucial for regulating cranial neural crest cell proliferation during frontal bone development. Sasaki, T., Ito, Y., Bringas, P., Chou, S., Urata, M.M., Slavkin, H., Chai, Y. Development (2006) [Pubmed]
  7. Msx2 and Twist cooperatively control the development of the neural crest-derived skeletogenic mesenchyme of the murine skull vault. Ishii, M., Merrill, A.E., Chan, Y.S., Gitelman, I., Rice, D.P., Sucov, H.M., Maxson, R.E. Development (2003) [Pubmed]
  8. Differences in the extent and heterogeneity of lysyl hydroxylation in embryonic chick cranial and long bone collagens. Strawich, E., Glimcher, M.J. J. Biol. Chem. (1983) [Pubmed]
  9. Tissue origins and interactions in the mammalian skull vault. Jiang, X., Iseki, S., Maxson, R.E., Sucov, H.M., Morriss-Kay, G.M. Dev. Biol. (2002) [Pubmed]
  10. Deer antlers as a model of Mammalian regeneration. Price, J., Faucheux, C., Allen, S. Curr. Top. Dev. Biol. (2005) [Pubmed]
  11. Sinus disease. Freeman, D.E. Vet. Clin. North Am. Equine Pract. (2003) [Pubmed]
  12. Morphogenesis of the mouse coronal suture. Johansen, V.A., Hall, S.H. Acta anatomica. (1982) [Pubmed]
  13. Stimulation of bone formation in vivo by transforming growth factor-beta: remodeling of woven bone and lack of inhibition by indomethacin. Mackie, E.J., Trechsel, U. Bone (1990) [Pubmed]
  14. Cranial burr hole for revascularization in moyamoya disease. Endo, M., Kawano, N., Miyaska, Y., Yada, K. J. Neurosurg. (1989) [Pubmed]
  15. Osseointegration in sinus-forming bone. Coombs, C.J., Mutimer, K.L., Holmes, A.D., Levant, B.A., Courtemanche, D.J., Clement, J.G. Plast. Reconstr. Surg. (1995) [Pubmed]
  16. Roentgen stereometry with the aid of metallic implants in hemifacial microsomia. Rune, B., Sarnäs, K.V., Selvik, G., Jacobsson, S. American journal of orthodontics. (1983) [Pubmed]
  17. Inhibition of cell metabolism by a smokeless tobacco extract: tissue and species specificity. Lenz, L.G., Ramp, W.K., Galvin, R.J., Pierce, W.M. Proc. Soc. Exp. Biol. Med. (1992) [Pubmed]
  18. The effects of mechanical immobilization on sutural development in the growing rabbit. Foley, W.J., Kokich, V.G. J. Neurosurg. (1980) [Pubmed]
  19. Failure of hydroxyapatite cement to set in repair of a cranial defect: case report. Maniker, A., Cantrell, S., Vaicys, C. Neurosurgery (1998) [Pubmed]
  20. Growth pattern of the rabbit snout dorsum: a serial cephalometric radiographic study with radiopaque implants. Sarnat, B.G., Selman, A.J. J. Anat. (1977) [Pubmed]
  21. Tricalcium phosphate and osteogenin: a bioactive onlay bone graft substitute. Breitbart, A.S., Staffenberg, D.A., Thorne, C.H., Glat, P.M., Cunningham, N.S., Reddi, A.H., Ricci, J., Steiner, G. Plast. Reconstr. Surg. (1995) [Pubmed]
  22. Knobloch syndrome involving midline scalp defect of the frontal region. Sniderman, L.C., Koenekoop, R.K., O'Gorman, A.M., Usher, R.H., Sufrategui, M.R., Moroz, B., Watters, G.V., Der Kaloustian, V.M. Am. J. Med. Genet. (2000) [Pubmed]
  23. Spontaneous regression of a large hepatocellular carcinoma with skull metastasis. Nam, S.W., Han, J.Y., Kim, J.I., Park, S.H., Cho, S.H., Han, N.I., Yang, J.M., Kim, J.K., Choi, S.W., Lee, Y.S., Chung, K.W., Sun, H.S. J. Gastroenterol. Hepatol. (2005) [Pubmed]
  24. Hydrocephalus in the laboratory rat. Park, A.W., Nowosielski-Slepowron, B.J. Acta morphologica Neerlando-Scandinavica. (1979) [Pubmed]
  25. Use of a rivet-like titanium clamp closure system to replace an external frontal bone flap after transfrontal craniotomy in a dog. Gordon, P.N., Kornegay, J.N., Lattimer, J.C., Cook, C.R., Tucker-Warhover, T. J. Am. Vet. Med. Assoc. (2005) [Pubmed]
  26. Prenatal diagnosis of de novo interstitial 16q deletion in a fetus associated with sonographic findings of prominent coronal sutures, a prominent frontal bone, and shortening of the long bones. Chen, C.P., Chern, S.R., Lee, C.C., Chen, L.F., Chuang, C.Y. Prenat. Diagn. (1998) [Pubmed]
  27. Ultrastructural analysis of metal particles released from stainless steel and titanium miniplate components in an animal model. Matthew, I.R., Frame, J.W. J. Oral Maxillofac. Surg. (1998) [Pubmed]
  28. The Mini-Cap. External immobilization of facial fractures. Nielsen, A., Poulsen, H. Scandinavian journal of plastic and reconstructive surgery. (1985) [Pubmed]
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