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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Dentinogenesis


High impact information on Dentinogenesis


Biological context of Dentinogenesis


Anatomical context of Dentinogenesis


Associations of Dentinogenesis with chemical compounds


Gene context of Dentinogenesis

  • These two domains and the colocalization of Dmp1 and Dmp2 genes at a position equivalent to the dentinogenesis imperfecta type II location on human 4q21 all suggest that the PPs are indeed involved in some aspect of ECM mineralization [23].
  • A novel splice acceptor mutation in the DSPP gene causing dentinogenesis imperfecta type II [24].
  • We envision that the proteolytic processing of DMP1 and DSPP may be an activation process that plays a significant, crucial role in osteogenesis and dentinogenesis, and that a failure in this processing would cause defective mineralization in bone and dentin, as observed in X-linked hypophosphatemic rickets [25].
  • Recent evidence has implicated proteins belonging to the bone morphogenetic protein (BMP) subgroup of the transforming growth factor beta supergene family in tooth formation and dentinogenesis [26].
  • We furthermore examined dentinogenesis in tooth explants cultured in the presence of warfarin (an inhibitor of gamma-carboxylation of OC) [27].

Analytical, diagnostic and therapeutic context of Dentinogenesis


  1. Dentin sialoprotein and phosphoprotein induce neutrophil recruitment: a mechanism dependent on IL-1beta, TNF-beta, and CXC chemokines. Silva, T.A., Lara, V.S., Silva, J.S., Garlet, G.P., Butler, W.T., Cunha, F.Q. Calcif. Tissue Int. (2004) [Pubmed]
  2. Treatment of inflamed ferret dental pulps with recombinant bone morphogenetic protein-7. Rutherford, R.B., Gu, K. Eur. J. Oral Sci. (2000) [Pubmed]
  3. Effects of thyro-parathyroidectomy and parathyroidectomy upon dentinogenesis: Part I: Light microscopy. Chardin, H., Acevedo, A.C., Septier, D., Staub, J.F., Goldberg, M. Connect. Tissue Res. (1995) [Pubmed]
  4. Effects of a high sucrose diet and intragastric sucrose feeding on the dentinogenesis, dental caries, and mineral excretion of the young rat. Pekkala, E., Hietala, E.L., Puukka, M., Larmas, M. Acta Odontol. Scand. (2000) [Pubmed]
  5. Prosthodontic and psychological factors in treating patients with congenital and craniofacial defects. Hickey, A.J., Salter, M. The Journal of prosthetic dentistry. (2006) [Pubmed]
  6. DSPP mutation in dentinogenesis imperfecta Shields type II. Zhang, X., Zhao, J., Li, C., Gao, S., Qiu, C., Liu, P., Wu, G., Qiang, B., Lo, W.H., Shen, Y. Nat. Genet. (2001) [Pubmed]
  7. Dmp1-deficient mice display severe defects in cartilage formation responsible for a chondrodysplasia-like phenotype. Ye, L., Mishina, Y., Chen, D., Huang, H., Dallas, S.L., Dallas, M.R., Sivakumar, P., Kunieda, T., Tsutsui, T.W., Boskey, A., Bonewald, L.F., Feng, J.Q. J. Biol. Chem. (2005) [Pubmed]
  8. Deletion of dentin matrix protein-1 leads to a partial failure of maturation of predentin into dentin, hypomineralization, and expanded cavities of pulp and root canal during postnatal tooth development. Ye, L., MacDougall, M., Zhang, S., Xie, Y., Zhang, J., Li, Z., Lu, Y., Mishina, Y., Feng, J.Q. J. Biol. Chem. (2004) [Pubmed]
  9. Evidence for the proteolytic processing of dentin matrix protein 1. Identification and characterization of processed fragments and cleavage sites. Qin, C., Brunn, J.C., Cook, R.G., Orkiszewski, R.S., Malone, J.P., Veis, A., Butler, W.T. J. Biol. Chem. (2003) [Pubmed]
  10. Reduced expression of dentin sialophosphoprotein is associated with dysplastic dentin in mice overexpressing transforming growth factor-beta 1 in teeth. Thyagarajan, T., Sreenath, T., Cho, A., Wright, J.T., Kulkarni, A.B. J. Biol. Chem. (2001) [Pubmed]
  11. The role of osteonectin in human tooth development: an immunohistological study. Reichert, T., Störkel, S., Becker, K., Fisher, L.W. Calcif. Tissue Int. (1992) [Pubmed]
  12. Site-specific expression of mRNAs for osteonectin, osteocalcin, and osteopontin revealed by in situ hybridization in rat periodontal ligament during physiological tooth movement. Takano-Yamamoto, T., Takemura, T., Kitamura, Y., Nomura, S. J. Histochem. Cytochem. (1994) [Pubmed]
  13. Dentin matrix proteins. Butler, W.T. Eur. J. Oral Sci. (1998) [Pubmed]
  14. Mutation of the signal peptide region of the bicistronic gene DSPP affects translocation to the endoplasmic reticulum and results in defective dentine biomineralization. Rajpar, M.H., Koch, M.J., Davies, R.M., Mellody, K.T., Kielty, C.M., Dixon, M.J. Hum. Mol. Genet. (2002) [Pubmed]
  15. Growth-hormone-stimulated dentinogenesis in Lewis dwarf rat molars. Young, W.G., Li, H., Xiao, Y., Waters, M.J., Bartold, P.M. J. Dent. Res. (2001) [Pubmed]
  16. Developmental appearance of dentin matrix protein 1 during the early dentinogenesis in rat molars as identified by high-resolution immunocytochemistry. Massa, L.F., Ramachandran, A., George, A., Arana-Chavez, V.E. Histochem. Cell Biol. (2005) [Pubmed]
  17. Inability of calcium hydroxide to induce reparative dentinogenesis at non-peripheral sites of dog dental pulp. Tziafas, D., Veis, A., Alvanou, A. Eur. J. Oral Sci. (1996) [Pubmed]
  18. The effect of a high-sucrose diet on dentin formation and dental caries in hyperinsulinemic rats. Pekkala, E., Välikangas, L., Puukka, M., Tjäderhane, L., Larmas, M. J. Dent. Res. (2002) [Pubmed]
  19. Immunolocalization of fibronectin during reparative dentinogenesis in human teeth after pulp capping with calcium hydroxide. Yoshiba, K., Yoshiba, N., Nakamura, H., Iwaku, M., Ozawa, H. J. Dent. Res. (1996) [Pubmed]
  20. Putative role of basement membrane for dentinogenesis in the mesenchyme of murine dental papillae in vitro. Kikuchi, H., Amano, H., Yamada, S. Cell Tissue Res. (2001) [Pubmed]
  21. A fine structural study of coronal and root dentinogensis in the mouse: observations on the so-called 'von Korff fibres' and their contribution to mantle dentine. Ten Cate, A.R. J. Anat. (1978) [Pubmed]
  22. Effect of xylitol on dentin formation in molars of adult rats. Tjäderhane, L., Hakala, P., Mattila, P., Svanberg, M., Larmas, M. Eur. J. Oral Sci. (1996) [Pubmed]
  23. The carboxyl-terminal domain of phosphophoryn contains unique extended triplet amino acid repeat sequences forming ordered carboxyl-phosphate interaction ridges that may be essential in the biomineralization process. George, A., Bannon, L., Sabsay, B., Dillon, J.W., Malone, J., Veis, A., Jenkins, N.A., Gilbert, D.J., Copeland, N.G. J. Biol. Chem. (1996) [Pubmed]
  24. A novel splice acceptor mutation in the DSPP gene causing dentinogenesis imperfecta type II. Kim, J.W., Nam, S.H., Jang, K.T., Lee, S.H., Kim, C.C., Hahn, S.H., Hu, J.C., Simmer, J.P. Hum. Genet. (2004) [Pubmed]
  25. Post-translational modifications of sibling proteins and their roles in osteogenesis and dentinogenesis. Qin, C., Baba, O., Butler, W.T. Crit. Rev. Oral Biol. Med. (2004) [Pubmed]
  26. A new biological approach to vital pulp therapy. Rutherford, B., Fitzgerald, M. Crit. Rev. Oral Biol. Med. (1995) [Pubmed]
  27. Studies of osteocalcin function in dentin formation in rodent teeth. Bronckers, A.L., Price, P.A., Schrijvers, A., Bervoets, T.J., Karsenty, G. Eur. J. Oral Sci. (1998) [Pubmed]
  28. Immunohistochemistry of extracellular matrix proteins during various stages of dentinogenesis. Bronckers, A.L., Lyaruu, D.M., Wöltgens, J.H. Connect. Tissue Res. (1989) [Pubmed]
  29. Induction of reparative dentinogenesis in vivo: a synthesis of experimental observations. Tziafas, D. Connect. Tissue Res. (1995) [Pubmed]
  30. In vitro characterization of poly(ethylene) glycol calcium citrate microspheres as a delivery system for the study of reparative dentinogenesis. Hunter, A.R., Kirk, E.E., Robinson, D.H., Kardos, T.B. Endodontics & dental traumatology. (1998) [Pubmed]
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