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Gene Review

Lypla1  -  lysophospholipase 1

Mus musculus

Synonyms: APT-1, Acyl-protein thioesterase 1, Apt1, LPL-I, LysoPLA I, ...
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Disease relevance of Lypla1


High impact information on Lypla1

  • This alpha2-adrenergic-dependent trophic activity was completely abolished by pretreatment of the conditioned media or microdialysates with the lysophospholipase, phospholipase B. Among the different lysophospholipids tested only lysophosphatidic acid (LPA) was able to induce spreading and proliferation of 3T3F442A preadipocytes [6].
  • This hypothesis is tested here in mouse brain by replacing the phenyl valerate substrate of the standard NTE assay with lysolecithin for an "NTE-LysoPLA" assay with four important findings [2].
  • The active site region of NTE as a recombinant protein preferentially hydrolyzes lysolecithin, suggesting that this enzyme may be a type of lysophospholipase (LysoPLA) with lysolecithin as its physiological substrate [2].
  • Autotaxin, a secreted lysophospholipase D, is essential for blood vessel formation during development [3].
  • We also addressed the recent proposal that nSMase 1 possesses lysophospholipase C activity [7].

Biological context of Lypla1


Anatomical context of Lypla1


Associations of Lypla1 with chemical compounds


Other interactions of Lypla1


Analytical, diagnostic and therapeutic context of Lypla1

  • Northern blot analysis and reverse transcription-polymerase chain reaction revealed that lysophospholipase II transcript as well as lysophospholipase I transcript was widely distributed in mouse tissues [1].
  • Therefore, OP-induced delayed toxicity in mice, and possibly the hyperactivity associated with NTE deficiency, may be due to NTE-LysoPLA inhibition, leading to localized accumulation of lysolecithin, a known demyelinating agent and receptor-mediated signal transducer [2].


  1. Sequence, expression in Escherichia coli, and characterization of lysophospholipase II. Toyoda, T., Sugimoto, H., Yamashita, S. Biochim. Biophys. Acta (1999) [Pubmed]
  2. Evidence that mouse brain neuropathy target esterase is a lysophospholipase. Quistad, G.B., Barlow, C., Winrow, C.J., Sparks, S.E., Casida, J.E. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  3. Autotaxin, a secreted lysophospholipase D, is essential for blood vessel formation during development. van Meeteren, L.A., Ruurs, P., Stortelers, C., Bouwman, P., van Rooijen, M.A., Pradère, J.P., Pettit, T.R., Wakelam, M.J., Saulnier-Blache, J.S., Mummery, C.L., Moolenaar, W.H., Jonkers, J. Mol. Cell. Biol. (2006) [Pubmed]
  4. Effect of anti-thymocyte serum on the eosinophil and lysophospholipase responses in mice infected with Trichinella spiralis. Adewusi, K., Goven, A.J. Parasitology (1987) [Pubmed]
  5. Control and location of acyl-hydrolysing phospholipase activity in pathogenic mycobacteria. Wheeler, P.R., Ratledge, C. J. Gen. Microbiol. (1992) [Pubmed]
  6. Alpha2-adrenergic receptor-mediated release of lysophosphatidic acid by adipocytes. A paracrine signal for preadipocyte growth. Valet, P., Pagès, C., Jeanneton, O., Daviaud, D., Barbe, P., Record, M., Saulnier-Blache, J.S., Lafontan, M. J. Clin. Invest. (1998) [Pubmed]
  7. Neutral sphingomyelinase 1 deficiency in the mouse causes no lipid storage disease. Zumbansen, M., Stoffel, W. Mol. Cell. Biol. (2002) [Pubmed]
  8. Cloning, expression, and catalytic mechanism of murine lysophospholipase I. Wang, A., Deems, R.A., Dennis, E.A. J. Biol. Chem. (1997) [Pubmed]
  9. Potential involvement of adipocyte insulin resistance in obesity-associated up-regulation of adipocyte lysophospholipase D/autotaxin expression. Boucher, J., Quilliot, D., Pradères, J.P., Simon, M.F., Grès, S., Guigné, C., Prévot, D., Ferry, G., Boutin, J.A., Carpéné, C., Valet, P., Saulnier-Blache, J.S. Diabetologia (2005) [Pubmed]
  10. Analysis of hydrolytic products from choline-labeled host cell phospholipids during growth of Rickettsia prowazekii. Winkler, H.H., Day, L., Daugherty, R. Infect. Immun. (1994) [Pubmed]
  11. Regulation of lysophospholipase activity of the 85-kDa phospholipase A2 and activation in mouse peritoneal macrophages. de Carvalho, M.G., Garritano, J., Leslie, C.C. J. Biol. Chem. (1995) [Pubmed]
  12. Lysophosphatidic acid inhibits adipocyte differentiation via lysophosphatidic acid 1 receptor-dependent down-regulation of peroxisome proliferator-activated receptor gamma2. Simon, M.F., Daviaud, D., Pradère, J.P., Grès, S., Guigné, C., Wabitsch, M., Chun, J., Valet, P., Saulnier-Blache, J.S. J. Biol. Chem. (2005) [Pubmed]
  13. Biochemical and molecular characterization of a novel choline-specific glycerophosphodiester phosphodiesterase belonging to the nucleotide pyrophosphatase/phosphodiesterase family. Sakagami, H., Aoki, J., Natori, Y., Nishikawa, K., Kakehi, Y., Natori, Y., Arai, H. J. Biol. Chem. (2005) [Pubmed]
  14. Platelet-activating factor antagonist BN52021 decreases accumulation of free polyunsaturated fatty acid in mouse brain during ischemia and electroconvulsive shock. Birkle, D.L., Kurian, P., Braquet, P., Bazan, N.G. J. Neurochem. (1988) [Pubmed]
  15. Phospholipid-derived choline intermediates and acetylcholine synthesis in mouse brain synaptosomes. Yavin, E., Tanaka, Y., Ando, S. J. Neurosci. Res. (1989) [Pubmed]
  16. Stimulation of leukocyte lysophospholipase activity by noninfectious agents. Hall, P.A., Laubach, H.E. Proc. Soc. Exp. Biol. Med. (1991) [Pubmed]
  17. Isolation and characterization of three lysophospholipases from the murine macrophage cell line WEHI 265.1. Garsetti, D.E., Ozgür, L.E., Steiner, M.R., Egan, R.W., Clark, M.A. Biochim. Biophys. Acta (1992) [Pubmed]
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