Gene Review:
Khdrbs1 - KH domain containing, RNA binding, signal...
Mus musculus
Synonyms:
GAP-associated tyrosine phosphoprotein p62, KH domain-containing, RNA-binding, signal transduction-associated protein 1, Sam68, Src-associated in mitosis 68 kDa protein, p21 Ras GTPase-activating protein-associated p62, ...
- Ablation of the Sam68 RNA binding protein protects mice from age-related bone loss. Richard, S., Torabi, N., Franco, G.V., Tremblay, G.A., Chen, T., Vogel, G., Morel, M., Cléroux, P., Forget-Richard, A., Komarova, S., Tremblay, M.L., Li, W., Li, A., Gao, Y.J., Henderson, J.E. PLoS Genet. (2005)
- p62 ubiquitin binding-associated domain mediated the receptor activator of nuclear factor-kappaB ligand-induced osteoclast formation: a new insight into the pathogenesis of Paget's disease of bone. Yip, K.H., Feng, H., Pavlos, N.J., Zheng, M.H., Xu, J. Am. J. Pathol. (2006)
- A 68 000 dalton protein genetically associated with corticotropin-sensitive adenylate cyclase activity. Purification and preliminary characterization using a specific antiserum. Schimmer, B.P., Robinson, R., Tsao, J., Watt, V.M. Can. J. Biochem. Cell Biol. (1984)
- Role of the second-largest subunit of DNA polymerase alpha in the interaction between the catalytic subunit and hyperphosphorylated retinoblastoma protein in late S phase. Takemura, M., Yoshida, S., Akiyama, T., Kitagawa, M., Yamada, Y. Biochim. Biophys. Acta (2006)
- A target for Src in mitosis. Fumagalli, S., Totty, N.F., Hsuan, J.J., Courtneidge, S.A. Nature (1994)
- The signaling adapter p62 is an important mediator of T helper 2 cell function and allergic airway inflammation. Martin, P., Diaz-Meco, M.T., Moscat, J. EMBO J. (2006)
- Identification of Src, Fyn, and Lyn SH3-binding proteins: implications for a function of SH3 domains. Weng, Z., Thomas, S.M., Rickles, R.J., Taylor, J.A., Brauer, A.W., Seidel-Dugan, C., Michael, W.M., Dreyfuss, G., Brugge, J.S. Mol. Cell. Biol. (1994)
- The nuclear RNA-binding protein Sam68 translocates to the cytoplasm and associates with the polysomes in mouse spermatocytes. Paronetto, M.P., Zalfa, F., Botti, F., Geremia, R., Bagni, C., Sette, C. Mol. Biol. Cell (2006)
- Gene expression profiling in the striatum of inbred mouse strains with distinct opioid-related phenotypes. Korostynski, M., Kaminska-Chowaniec, D., Piechota, M., Przewlocki, R. BMC Genomics (2006)
- Neoplastic transformation and tumorigenesis associated with sam68 protein deficiency in cultured murine fibroblasts. Liu, K., Li, L., Nisson, P.E., Gruber, C., Jessee, J., Cohen, S.N. J. Biol. Chem. (2000)
- Fyn membrane localization is necessary to induce the constitutive tyrosine phosphorylation of Sam68 in the nucleus of T lymphocytes. Lang, V., Semichon, M., Michel, F., Brossard, C., Gary-Gouy, H., Bismuth, G. J. Immunol. (1999)
- Increased levels of p21ras-GTP and enhanced DNA synthesis accompany elevated tyrosyl phosphorylation of GAP-associated proteins, p190 and p62, in c-src overexpressors. Chang, J.H., Wilson, L.K., Moyers, J.S., Zhang, K., Parsons, S.J. Oncogene (1993)
- Sam68 is a Ras-GAP-associated protein in mitosis. Guitard, E., Barlat, I., Maurier, F., Schweighoffer, F., Tocque, B. Biochem. Biophys. Res. Commun. (1998)
- RACK1 regulates Src-mediated Sam68 and p190RhoGAP signaling. Miller, L.D., Lee, K.C., Mochly-Rosen, D., Cartwright, C.A. Oncogene (2004)
- Radicicol inhibits tyrosine phosphorylation of the mitotic Src substrate Sam68 and retards subsequent exit from mitosis of Src-transformed cells. Pillay, I., Nakano, H., Sharma, S.V. Cell Growth Differ. (1996)
- The second-largest subunit of the mouse DNA polymerase alpha-primase complex facilitates both production and nuclear translocation of the catalytic subunit of DNA polymerase alpha. Mizuno, T., Ito, N., Yokoi, M., Kobayashi, A., Tamai, K., Miyazawa, H., Hanaoka, F. Mol. Cell. Biol. (1998)
- Increased detection of specific tyrosine phosphoproteins correlates with tumor progression of Abelson virus-infected lymphocytes. Clark, S.S., Liang, Y. Leukemia (1995)