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Gene Review

Ccl25  -  chemokine (C-C motif) ligand 25

Mus musculus

Synonyms: A130072A22Rik, AI852536, C-C motif chemokine 25, CKb15, Chemokine TECK, ...
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Disease relevance of Ccl25


High impact information on Ccl25

  • These findings provide profound in vivo evidence that CCL25/CCR9 guides PCs into the small intestine [2].
  • These recently activated CCR9(+) CD8alphabeta(+) lymphocytes selectively localized to the small-intestinal mucosa, and in vivo neutralization of the CCR9 ligand, CCL25, reduced the ability of these cells to populate the small-intestinal epithelium [3].
  • CCL25 mediates the localization of recently activated CD8alphabeta(+) lymphocytes to the small-intestinal mucosa [3].
  • Together these results demonstrate an important role for chemokines in the localization of T lymphocytes to the small-intestinal mucosa and suggest that targeting CCL25 and/or CCR9 may provide a means to selectively modulate small-intestinal immune responses [3].
  • Background & Aims: CCL25 mediates the homeostatic recruitment of CCR9-expressing lymphocytes to the small intestine, but the function of this chemokine/receptor pair during chronic small intestinal inflammation has yet to be determined [1].

Biological context of Ccl25


Anatomical context of Ccl25


Associations of Ccl25 with chemical compounds

  • Neonatal CD8+ splenocytes uniformly express alpha(E) integrin and exhibit a high responsiveness to CC chemokine ligand (CCL25) (as compared with adult CD8+ splenocytes) [7].
  • The levels of IL-7, SDF-1alpha, TECK, and SLC mRNA inversely correlated with the kinetics of regeneration [11].

Other interactions of Ccl25

  • Reciprocally, CT-specific ASCs and IgA titers in the blood were increased in mice treated with anti-CCL25 or anti-CCL28 [9].
  • Murine CCR9, a chemokine receptor for thymus-expressed chemokine that is up-regulated following pre-TCR signaling [4].
  • Increased expression of TECK/CCL25 by TNF-alpha was observed in the lamina propria of small intestine [10].
  • The in vivo significance of this finding is demonstrated by studies in the nude mouse where the thymic anlage lacks TECK and SDF-1 expression and prothymocytes home to the parathyroid anlage rather than to the thymic anlage [12].
  • However, fetal thymus colonization was markedly diminished by neutralizing antibodies specific for CCL21 and CCL25, but not affected by anti-CXCL12 antibody [13].


  1. Antibody Blockade of CCL25/CCR9 Ameliorates Early but not Late Chronic Murine Ileitis. Rivera-Nieves, J., Ho, J., Bamias, G., Ivashkina, N., Ley, K., Oppermann, M., Cominelli, F. Gastroenterology (2006) [Pubmed]
  2. Chemokine receptor CCR9 contributes to the localization of plasma cells to the small intestine. Pabst, O., Ohl, L., Wendland, M., Wurbel, M.A., Kremmer, E., Malissen, B., Förster, R. J. Exp. Med. (2004) [Pubmed]
  3. CCL25 mediates the localization of recently activated CD8alphabeta(+) lymphocytes to the small-intestinal mucosa. Svensson, M., Marsal, J., Ericsson, A., Carramolino, L., Brodén, T., Márquez, G., Agace, W.W. J. Clin. Invest. (2002) [Pubmed]
  4. Murine CCR9, a chemokine receptor for thymus-expressed chemokine that is up-regulated following pre-TCR signaling. Norment, A.M., Bogatzki, L.Y., Gantner, B.N., Bevan, M.J. J. Immunol. (2000) [Pubmed]
  5. The chemokine TECK is expressed by thymic and intestinal epithelial cells and attracts double- and single-positive thymocytes expressing the TECK receptor CCR9. Wurbel, M.A., Philippe, J.M., Nguyen, C., Victorero, G., Freeman, T., Wooding, P., Miazek, A., Mattei, M.G., Malissen, M., Jordan, B.R., Malissen, B., Carrier, A., Naquet, P. Eur. J. Immunol. (2000) [Pubmed]
  6. Cutting edge: developmental switches in chemokine responses during T cell maturation. Campbell, J.J., Pan, J., Butcher, E.C. J. Immunol. (1999) [Pubmed]
  7. Murine CD8+ recent thymic emigrants are alphaE integrin-positive and CC chemokine ligand 25 responsive. Staton, T.L., Johnston, B., Butcher, E.C., Campbell, D.J. J. Immunol. (2004) [Pubmed]
  8. Characterization of CCR9 expression and CCL25/thymus-expressed chemokine responsiveness during T cell development: CD3(high)CD69+ thymocytes and gammadeltaTCR+ thymocytes preferentially respond to CCL25. Uehara, S., Song, K., Farber, J.M., Love, P.E. J. Immunol. (2002) [Pubmed]
  9. CC chemokine ligands 25 and 28 play essential roles in intestinal extravasation of IgA antibody-secreting cells. Hieshima, K., Kawasaki, Y., Hanamoto, H., Nakayama, T., Nagakubo, D., Kanamaru, A., Yoshie, O. J. Immunol. (2004) [Pubmed]
  10. Demonstration of functional role of TECK/CCL25 in T lymphocyte-endothelium interaction in inflamed and uninflamed intestinal mucosa. Hosoe, N., Miura, S., Watanabe, C., Tsuzuki, Y., Hokari, R., Oyama, T., Fujiyama, Y., Nagata, H., Ishii, H. Am. J. Physiol. Gastrointest. Liver Physiol. (2004) [Pubmed]
  11. Up-regulation of IL-7, stromal-derived factor-1 alpha, thymus-expressed chemokine, and secondary lymphoid tissue chemokine gene expression in the stromal cells in response to thymocyte depletion: implication for thymus reconstitution. Zubkova, I., Mostowski, H., Zaitseva, M. J. Immunol. (2005) [Pubmed]
  12. Chemokines define distinct microenvironments in the developing thymus. Bleul, C.C., Boehm, T. Eur. J. Immunol. (2000) [Pubmed]
  13. The role of CCL21 in recruitment of T-precursor cells to fetal thymi. Liu, C., Ueno, T., Kuse, S., Saito, F., Nitta, T., Piali, L., Nakano, H., Kakiuchi, T., Lipp, M., Hollander, G.A., Takahama, Y. Blood (2005) [Pubmed]
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