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Gene Review

Spn  -  sialophorin

Mus musculus

Synonyms: 3E8 antigen, A630014B01Rik, B-cell differentiation antigen LP-3, Cd43, Galgp, ...
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Disease relevance of Spn


High impact information on Spn


Biological context of Spn


Anatomical context of Spn


Associations of Spn with chemical compounds

  • Specific labeling of the sialoglycoproteins of RDM-4 cells indicates that leukosialin, the most intensely labeled protein, comigrates with the sulfated protein on SDS-PAGE at varying acrylamide concentrations [5].

Other interactions of Spn

  • Blocking studies with various antibodies revealed that leukosialin (S11 monoclonal antibodies) and TNF alpha were important for Thy-1+DEC migration [15].
  • Soluble forms of leukosialin or lamp-1 may be useful as therapeutic agents for the inhibition of E-selectin-mediated binding to tumor cells [16].
  • Results from lectin chromatography and N-glycanase and neuraminidase studies suggest that the 3E8 antigen is a heavily sialylated O-linked glycoprotein [17].

Analytical, diagnostic and therapeutic context of Spn

  • To determine whether Ly 48 is expressed by specific subsets of epidermal cells (ECs) such as Langerhans cells, keratinocytes, or dendritic epidermal T cells (DETCs), we utilized flow cytometry to detect staining of ECs by a panel of four monoclonal antibodies (S11, S15, S7, and 3E8) that recognize two different epitopes of the leukosialin antigen [18].


  1. A macrophage invasion mechanism for mycobacteria implicating the extracellular domain of CD43. Fratazzi, C., Manjunath, N., Arbeit, R.D., Carini, C., Gerken, T.A., Ardman, B., Remold-O'Donnell, E., Remold, H.G. J. Exp. Med. (2000) [Pubmed]
  2. Disregulation of leukosialin (CD43, Ly48, sialophorin) expression in the B-cell lineage of transgenic mice increases splenic B-cell number and survival. Dragone, L.L., Barth, R.K., Sitar, K.L., Disbrow, G.L., Frelinger, J.G. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  3. Amplification and rearrangement of melF/mouse CD43 (leukosialin) gene encoding a highly glycosylated membrane protein gp120 in Friend erythroleukemia cells. Misawa, Y., Shibuya, M. Oncogene (1992) [Pubmed]
  4. Concentration of an integral membrane protein, CD43 (leukosialin, sialophorin), in the cleavage furrow through the interaction of its cytoplasmic domain with actin-based cytoskeletons. Yonemura, S., Nagafuchi, A., Sato, N., Tsukita, S. J. Cell Biol. (1993) [Pubmed]
  5. Evidence that leukosialin, CD43, is intensely sulfated in the murine T lymphoma line RDM-4. Wilson, A.P., Rider, C.C. J. Immunol. (1992) [Pubmed]
  6. Enhancement of T-cell activation by the CD43 molecule whose expression is defective in Wiskott-Aldrich syndrome. Park, J.K., Rosenstein, Y.J., Remold-O'Donnell, E., Bierer, B.E., Rosen, F.S., Burakoff, S.J. Nature (1991) [Pubmed]
  7. Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow. Hardy, R.R., Carmack, C.E., Shinton, S.A., Kemp, J.D., Hayakawa, K. J. Exp. Med. (1991) [Pubmed]
  8. Use of a monoclonal antibody (GA3) to demonstrate lineage restricted O-glycosylation on leukosialin during terminal erythroid differentiation. Bettaieb, A., Farace, F., Mitjavila, M.T., Mishal, Z., Dokhelar, M.C., Tursz, T., Breton-Gorius, J., Vainchenker, W., Kieffer, N. Blood (1988) [Pubmed]
  9. Structure and chromosomal localization of the murine gene encoding GLYCAM 1. A mucin-like endothelial ligand for L selectin. Dowbenko, D., Andalibi, A., Young, P.E., Lusis, A.J., Lasky, L.A. J. Biol. Chem. (1993) [Pubmed]
  10. The nucleotide sequence of Ly 48 (mouse leukosialin, sialophorin): the mouse homolog of CD43. Dorfman, K.S., Litaker, W., Baecher, C.M., Frelinger, J.G. Nucleic Acids Res. (1990) [Pubmed]
  11. Protein sequence and gene structure for mouse leukosialin (CD43), a T lymphocyte mucin without introns in the coding sequence. Cyster, J., Somoza, C., Killeen, N., Williams, A.F. Eur. J. Immunol. (1990) [Pubmed]
  12. Expression of mouse CD43 in the B cell lineage of transgenic mice causes impaired immune responses to T-independent antigens. Ostberg, J.R., Dragone, L.L., Borrello, M.A., Phipps, R.P., Barth, R.K., Frelinger, J.G. Eur. J. Immunol. (1997) [Pubmed]
  13. CD43 (S7) expression identifies peripheral B cell subsets. Wells, S.M., Kantor, A.B., Stall, A.M. J. Immunol. (1994) [Pubmed]
  14. Mechanism of mononuclear cell activation by an anti-CD43 (sialophorin) agonistic antibody. Silverman, L.B., Wong, R.C., Remold-O'Donnell, E., Vercelli, D., Sancho, J., Terhorst, C., Rosen, F., Geha, R., Chatila, T. J. Immunol. (1989) [Pubmed]
  15. Migration of Thy-1+ dendritic epidermal cells (Thy-1+DEC): Ly48 and TNF-alpha are responsible for the migration of Thy-1+DEC to the epidermis. Tamaki, K., Saitoh, A., Gaspari, A.A., Yasaka, N., Furue, M. J. Invest. Dermatol. (1994) [Pubmed]
  16. Differential E-selectin-dependent adhesion efficiency in sublines of a human colon cancer exhibiting distinct metastatic potentials. Sawada, R., Tsuboi, S., Fukuda, M. J. Biol. Chem. (1994) [Pubmed]
  17. Identification and characterization of a mouse cell surface antigen with alternative molecular forms. Baecher, C.M., Infante, A.J., Semcheski, K.L., Frelinger, J.G. Immunogenetics (1988) [Pubmed]
  18. Thy 1+ dendritic epidermal cells but not Langerhans cells express Ly 48. Gaspari, A.A., Ferbel, B., Frelinger, J.G. J. Invest. Dermatol. (1993) [Pubmed]
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