Gene Review:
SPN - sialophorin
Homo sapiens
Synonyms:
CD43, GALGP, GPL115, Galactoglycoprotein, LSN, ...
- Restricted receptor segregation into membrane microdomains occurs on human T cells during apoptosis induced by galectin-1. Pace, K.E., Lee, C., Stewart, P.L., Baum, L.G. J. Immunol. (1999)
- Engagement of CD43 enhances human immunodeficiency virus type 1 transcriptional activity and virus production that is induced upon TCR/CD3 stimulation. Barat, C., Tremblay, M.J. J. Biol. Chem. (2002)
- Proteolytic fragmentation of sialophorin (CD43). Localization of the activation-inducing site and examination of the role of sialic acid. Remold-O'Donnell, E., Rosen, F.S. J. Immunol. (1990)
- Novel CD43 specific phage antibodies react with early stage colorectal tumours. Pimenidou, A., Madden, L.A., Topping, K.P., Smith, K.A., Monson, J.R., Greenman, J. Oncol. Rep. (2004)
- Evaluation and management of solitary and multiple pulmonary nodules. Viggiano, R.W., Swensen, S.J., Rosenow, E.C. Clin. Chest Med. (1992)
- Role of neurotransmitters in the central regulation of the cardiovascular system. McCall, R.B. Progress in drug research. Fortschritte der Arzneimittelforschung. Progrès des recherches pharmaceutiques. (1990)
- Expression of CD43 in human microglia and its downregulation in Alzheimer's disease. Matsuo, A., Walker, D.G., Terai, K., McGeer, P.L. J. Neuroimmunol. (1996)
- Enhancement of T-cell activation by the CD43 molecule whose expression is defective in Wiskott-Aldrich syndrome. Park, J.K., Rosenstein, Y.J., Remold-O'Donnell, E., Bierer, B.E., Rosen, F.S., Burakoff, S.J. Nature (1991)
- Exclusion of CD43 from the immunological synapse is mediated by phosphorylation-regulated relocation of the cytoskeletal adaptor moesin. Delon, J., Kaibuchi, K., Germain, R.N. Immunity (2001)
- Obstructive uropathy associated with myelomonocytic infiltration of the prostate. Hope-Gill, B., Goepel, J.R., Collin, R.C. J. Clin. Pathol. (1998)
- Intercellular adhesion molecule-1. van de Stolpe, A., van der Saag, P.T. J. Mol. Med. (1996)
- Inhibition of NF-kappaB activation and chemokine expression by the leukocyte glycoprotein, CD43, in colon cancer cells. Laos, S., Baeckström, D., Hansson, G.C. Int. J. Oncol. (2006)
- Phenotyping of T-cell lymphomas in paraffin sections--which antibodies? Cabeçadas, J.M., Isaacson, P.G. Histopathology (1991)
- Molecular characterization of sialophorin (CD43), the lymphocyte surface sialoglycoprotein defective in Wiskott-Aldrich syndrome. Shelley, C.S., Remold-O'Donnell, E., Davis, A.E., Bruns, G.A., Rosen, F.S., Carroll, M.C., Whitehead, A.S. Proc. Natl. Acad. Sci. U.S.A. (1989)
- hnRNP-K and Pur(alpha) act together to repress the transcriptional activity of the CD43 gene promoter. Da Silva, N., Bharti, A., Shelley, C.S. Blood (2002)
- CD43 interacts with moesin and ezrin and regulates its redistribution to the uropods of T lymphocytes at the cell-cell contacts. Serrador, J.M., Nieto, M., Alonso-Lebrero, J.L., del Pozo, M.A., Calvo, J., Furthmayr, H., Schwartz-Albiez, R., Lozano, F., González-Amaro, R., Sánchez-Mateos, P., Sánchez-Madrid, F. Blood (1998)
- Enhanced T-cell activation and T-cell-dependent IL-2 production by CD83+, CD25(high), CD43(high) human monocyte-derived dendritic cells. Velten, F.W., Rambow, F., Metharom, P., Goerdt, S. Mol. Immunol. (2007)
- T cell lines characterize events in the pathogenesis of the Wiskott-Aldrich syndrome. Molina, I.J., Kenney, D.M., Rosen, F.S., Remold-O'Donnell, E. J. Exp. Med. (1992)
- Leukosialin (CD43) defines hematopoietic progenitors in human embryonic stem cell differentiation cultures. Vodyanik, M.A., Thomson, J.A., Slukvin, I.I. Blood (2006)
- Amino acid sequence of human plasma galactoglycoprotein: identity with the extracellular region of CD43 (sialophorin). Schmid, K., Hediger, M.A., Brossmer, R., Collins, J.H., Haupt, H., Marti, T., Offner, G.D., Schaller, J., Takagaki, K., Walsh, M.T. Proc. Natl. Acad. Sci. U.S.A. (1992)
- CD43 is a ligand for E-selectin on CLA+ human T cells. Fuhlbrigge, R.C., King, S.L., Sackstein, R., Kupper, T.S. Blood (2006)
- T cell activation through the CD43 molecule leads to Vav tyrosine phosphorylation and mitogen-activated protein kinase pathway activation. Pedraza-Alva, G., Mérida, L.B., Burakoff, S.J., Rosenstein, Y. J. Biol. Chem. (1998)
- CD43-mediated signals induce DNA binding activity of AP-1, NF-AT, and NFkappa B transcription factors in human T lymphocytes. Santana, M.A., Pedraza-Alva, G., Olivares-Zavaleta, N., Madrid-Marina, V., Horejsi, V., Burakoff, S.J., Rosenstein, Y. J. Biol. Chem. (2000)
- Cutting edge: CD43 functions as a T cell counterreceptor for the macrophage adhesion receptor sialoadhesin (Siglec-1). van den Berg, T.K., Nath, D., Ziltener, H.J., Vestweber, D., Fukuda, M., van Die, I., Crocker, P.R. J. Immunol. (2001)
- Galectin-1 Binds Different CD43 Glycoforms to Cluster CD43 and Regulate T Cell Death. Hernandez, J.D., Nguyen, J.T., He, J., Wang, W., Ardman, B., Green, J.M., Fukuda, M., Baum, L.G. J. Immunol. (2006)
- TCR-dependent cell response is modulated by the timing of CD43 engagement. Fierro, N.A., Pedraza-Alva, G., Rosenstein, Y. J. Immunol. (2006)
- Specific sensitivity of CD43 to neutrophil elastase. Remold-O'Donnell, E., Parent, D. Blood (1995)
- Expression characteristics and stimulatory functions of CD43 in human CD4+ memory T cells: analysis using a monoclonal antibody to CD43 that has a novel lineage specificity. Kyoizumi, S., Ohara, T., Kusunoki, Y., Hayashi, T., Koyama, K., Tsuyama, N. J. Immunol. (2004)
- Molecular mechanisms involved in CD43-mediated apoptosis of TF-1 cells. Roles of transcription Daxx expression, and adhesion molecules. Cermák, L., Símová, S., Pintzas, A., Horejsí, V., Andera, L. J. Biol. Chem. (2002)
- The size of the synaptic cleft and distinct distributions of filamentous actin, ezrin, CD43, and CD45 at activating and inhibitory human NK cell immune synapses. McCann, F.E., Vanherberghen, B., Eleme, K., Carlin, L.M., Newsam, R.J., Goulding, D., Davis, D.M. J. Immunol. (2003)
- Down-regulation by tumor necrosis factor-alpha of neutrophil cell surface expression of the sialophorin CD43 and the hyaluronate receptor CD44 through a proteolytic mechanism. Campanero, M.R., Pulido, R., Alonso, J.L., Pivel, J.P., Pimentel-Muiños, F.X., Fresno, M., Sánchez-Madrid, F. Eur. J. Immunol. (1991)
- Comparative analysis of T-cell costimulation and CD43 activation reveals novel signaling pathways and target genes. Mattioli, I., Dittrich-Breiholz, O., Livingstone, M., Kracht, M., Schmitz, M.L. Blood (2004)