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Gene Review

SPN  -  sialophorin

Homo sapiens

Synonyms: CD43, GALGP, GPL115, Galactoglycoprotein, LSN, ...
 
 
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Disease relevance of SPN

  • CD7 and CD43 colocalized in small patches away from the membrane blebs, which excluded externalized phosphatidylserine [1].
  • We demonstrate here that CD43 cross-linking potentiates HIV-1 promoter-driven activity and virus production that is seen following the engagement of the T-cell receptor (TCR).CD3 complex [2].
  • Engagement of CD43 enhances human immunodeficiency virus type 1 transcriptional activity and virus production that is induced upon TCR/CD3 stimulation [2].
  • Pancreatic elastase and Staphylococcus aureus V8 protease cleave CD43 at discrete extracellular sites [3].
  • These new anti-CD43 antibodies are likely to prove useful as screening tools in the detection of colorectal adenomas [4].
 

Psychiatry related information on SPN

 

High impact information on SPN

  • Enhancement of T-cell activation by the CD43 molecule whose expression is defective in Wiskott-Aldrich syndrome [8].
  • Anti-CD43 monoclonal antibodies have a modest costimulatory effect on T cells, natural killer cells, B cells and monocytes, and one such antibody has been shown to activate T cells directly [8].
  • We also found that antigen-presenting cells can bind specifically to immobilized purified CD43 and that the binding can be inhibited by liposomes containing CD43 as well as by anti-CD43 monoclonal antibodies [8].
  • To investigate a possible physiological role for CD43, a complementary DNA encoding the human protein was introduced into an antigen-responsive murine T-cell hybridoma [8].
  • Here, we demonstrate that TCR-induced exclusion of the large sialoprotein CD43 from the synapse is an active event mediated by its reversible binding to moesin [9].
 

Chemical compound and disease context of SPN

 

Biological context of SPN

 

Anatomical context of SPN

 

Associations of SPN with chemical compounds

  • Comparison of peptide sequences from the native galactoglycoprotein and the deglycosylated derivative demonstrated the locations of 25 sites of O-glycosylation and three serine sites that are not glycosylated [20].
  • In this report, we show that CD43, a sialomucin expressed constitutively on T cells, can also be decorated with the CLA epitope and serve as an E-selectin ligand [21].
  • T cell activation through the CD43 molecule leads to Vav tyrosine phosphorylation and mitogen-activated protein kinase pathway activation [22].
  • Pretreatment with sialidase enhances sensitivity 13-fold for trypsin, 40-fold for S. aureus V8 protease, and 400-fold for elastase, suggesting that sialic acid influences the survival of surface CD43 molecules when cells are exposed to protease [3].
  • Consistent with the transient CD43-dependent intracellular Ca(2+) peaks reported by others, signals generated through the CD43 molecule resulted in the induction of NF-AT DNA binding activity [23].
 

Physical interactions of SPN

  • CD43 interacts with moesin and ezrin and regulates its redistribution to the uropods of T lymphocytes at the cell-cell contacts [16].
  • Finally, sialoadhesin bound different glycoforms of CD43 expressed in Chinese hamster ovary cells, including unbranched (core 1) and branched (core 2) O:-linked glycans, that are normally found on CD43 in resting and activated T cells, respectively [24].
  • CD43-mediated signals induce DNA binding activity of AP-1, NF-AT, and NFkappa B transcription factors in human T lymphocytes [23].
  • Moreover, galectin-1 binding clustered CD43 modified with either core 1 or core 2 O-glycans on the T cell surface [25].
  • Provided that the coreceptor molecule CD43 is a very abundant molecule evenly distributed on the membrane of T cell surface protruding 45 nm from the cell, we hypothesized that CD43 is one of the first molecules that interacts with the APC and thus modulates TCR activation [26].
 

Enzymatic interactions of SPN

 

Regulatory relationships of SPN

  • hnRNP-K and Pur(alpha) act together to repress the transcriptional activity of the CD43 gene promoter [15].
  • CD43 expressed in COS cells supported increased binding to immobilized sialoadhesin [24].
  • Pro-activatory anti-CD43 monoclonal antibody (MoAb) induced polarization of T lymphocytes with redistribution of CD43 to the uropod and the CCR2 chemokine receptor to the leading edge of the cell [16].
  • Taken together, these findings suggest that the CD43 molecules expressed on CD4+ memory T cells may be capable of enhancing the costimulatory signaling and hence providing accessory functions to TCR-mediated activation processes [28].
  • CD43-mediated apoptosis was enhanced by coimmobilized anti-CD45 mAb and partly suppressed by coimmobilized anti-CD50 (ICAM-3) or anti-CD99 mAb [29].
 

Other interactions of SPN

 

Analytical, diagnostic and therapeutic context of SPN

References

  1. Restricted receptor segregation into membrane microdomains occurs on human T cells during apoptosis induced by galectin-1. Pace, K.E., Lee, C., Stewart, P.L., Baum, L.G. J. Immunol. (1999) [Pubmed]
  2. Engagement of CD43 enhances human immunodeficiency virus type 1 transcriptional activity and virus production that is induced upon TCR/CD3 stimulation. Barat, C., Tremblay, M.J. J. Biol. Chem. (2002) [Pubmed]
  3. Proteolytic fragmentation of sialophorin (CD43). Localization of the activation-inducing site and examination of the role of sialic acid. Remold-O'Donnell, E., Rosen, F.S. J. Immunol. (1990) [Pubmed]
  4. Novel CD43 specific phage antibodies react with early stage colorectal tumours. Pimenidou, A., Madden, L.A., Topping, K.P., Smith, K.A., Monson, J.R., Greenman, J. Oncol. Rep. (2004) [Pubmed]
  5. Evaluation and management of solitary and multiple pulmonary nodules. Viggiano, R.W., Swensen, S.J., Rosenow, E.C. Clin. Chest Med. (1992) [Pubmed]
  6. Role of neurotransmitters in the central regulation of the cardiovascular system. McCall, R.B. Progress in drug research. Fortschritte der Arzneimittelforschung. Progrès des recherches pharmaceutiques. (1990) [Pubmed]
  7. Expression of CD43 in human microglia and its downregulation in Alzheimer's disease. Matsuo, A., Walker, D.G., Terai, K., McGeer, P.L. J. Neuroimmunol. (1996) [Pubmed]
  8. Enhancement of T-cell activation by the CD43 molecule whose expression is defective in Wiskott-Aldrich syndrome. Park, J.K., Rosenstein, Y.J., Remold-O'Donnell, E., Bierer, B.E., Rosen, F.S., Burakoff, S.J. Nature (1991) [Pubmed]
  9. Exclusion of CD43 from the immunological synapse is mediated by phosphorylation-regulated relocation of the cytoskeletal adaptor moesin. Delon, J., Kaibuchi, K., Germain, R.N. Immunity (2001) [Pubmed]
  10. Obstructive uropathy associated with myelomonocytic infiltration of the prostate. Hope-Gill, B., Goepel, J.R., Collin, R.C. J. Clin. Pathol. (1998) [Pubmed]
  11. Intercellular adhesion molecule-1. van de Stolpe, A., van der Saag, P.T. J. Mol. Med. (1996) [Pubmed]
  12. Inhibition of NF-kappaB activation and chemokine expression by the leukocyte glycoprotein, CD43, in colon cancer cells. Laos, S., Baeckström, D., Hansson, G.C. Int. J. Oncol. (2006) [Pubmed]
  13. Phenotyping of T-cell lymphomas in paraffin sections--which antibodies? Cabeçadas, J.M., Isaacson, P.G. Histopathology (1991) [Pubmed]
  14. Molecular characterization of sialophorin (CD43), the lymphocyte surface sialoglycoprotein defective in Wiskott-Aldrich syndrome. Shelley, C.S., Remold-O'Donnell, E., Davis, A.E., Bruns, G.A., Rosen, F.S., Carroll, M.C., Whitehead, A.S. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  15. hnRNP-K and Pur(alpha) act together to repress the transcriptional activity of the CD43 gene promoter. Da Silva, N., Bharti, A., Shelley, C.S. Blood (2002) [Pubmed]
  16. CD43 interacts with moesin and ezrin and regulates its redistribution to the uropods of T lymphocytes at the cell-cell contacts. Serrador, J.M., Nieto, M., Alonso-Lebrero, J.L., del Pozo, M.A., Calvo, J., Furthmayr, H., Schwartz-Albiez, R., Lozano, F., González-Amaro, R., Sánchez-Mateos, P., Sánchez-Madrid, F. Blood (1998) [Pubmed]
  17. Enhanced T-cell activation and T-cell-dependent IL-2 production by CD83+, CD25(high), CD43(high) human monocyte-derived dendritic cells. Velten, F.W., Rambow, F., Metharom, P., Goerdt, S. Mol. Immunol. (2007) [Pubmed]
  18. T cell lines characterize events in the pathogenesis of the Wiskott-Aldrich syndrome. Molina, I.J., Kenney, D.M., Rosen, F.S., Remold-O'Donnell, E. J. Exp. Med. (1992) [Pubmed]
  19. Leukosialin (CD43) defines hematopoietic progenitors in human embryonic stem cell differentiation cultures. Vodyanik, M.A., Thomson, J.A., Slukvin, I.I. Blood (2006) [Pubmed]
  20. Amino acid sequence of human plasma galactoglycoprotein: identity with the extracellular region of CD43 (sialophorin). Schmid, K., Hediger, M.A., Brossmer, R., Collins, J.H., Haupt, H., Marti, T., Offner, G.D., Schaller, J., Takagaki, K., Walsh, M.T. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  21. CD43 is a ligand for E-selectin on CLA+ human T cells. Fuhlbrigge, R.C., King, S.L., Sackstein, R., Kupper, T.S. Blood (2006) [Pubmed]
  22. T cell activation through the CD43 molecule leads to Vav tyrosine phosphorylation and mitogen-activated protein kinase pathway activation. Pedraza-Alva, G., Mérida, L.B., Burakoff, S.J., Rosenstein, Y. J. Biol. Chem. (1998) [Pubmed]
  23. CD43-mediated signals induce DNA binding activity of AP-1, NF-AT, and NFkappa B transcription factors in human T lymphocytes. Santana, M.A., Pedraza-Alva, G., Olivares-Zavaleta, N., Madrid-Marina, V., Horejsi, V., Burakoff, S.J., Rosenstein, Y. J. Biol. Chem. (2000) [Pubmed]
  24. Cutting edge: CD43 functions as a T cell counterreceptor for the macrophage adhesion receptor sialoadhesin (Siglec-1). van den Berg, T.K., Nath, D., Ziltener, H.J., Vestweber, D., Fukuda, M., van Die, I., Crocker, P.R. J. Immunol. (2001) [Pubmed]
  25. Galectin-1 Binds Different CD43 Glycoforms to Cluster CD43 and Regulate T Cell Death. Hernandez, J.D., Nguyen, J.T., He, J., Wang, W., Ardman, B., Green, J.M., Fukuda, M., Baum, L.G. J. Immunol. (2006) [Pubmed]
  26. TCR-dependent cell response is modulated by the timing of CD43 engagement. Fierro, N.A., Pedraza-Alva, G., Rosenstein, Y. J. Immunol. (2006) [Pubmed]
  27. Specific sensitivity of CD43 to neutrophil elastase. Remold-O'Donnell, E., Parent, D. Blood (1995) [Pubmed]
  28. Expression characteristics and stimulatory functions of CD43 in human CD4+ memory T cells: analysis using a monoclonal antibody to CD43 that has a novel lineage specificity. Kyoizumi, S., Ohara, T., Kusunoki, Y., Hayashi, T., Koyama, K., Tsuyama, N. J. Immunol. (2004) [Pubmed]
  29. Molecular mechanisms involved in CD43-mediated apoptosis of TF-1 cells. Roles of transcription Daxx expression, and adhesion molecules. Cermák, L., Símová, S., Pintzas, A., Horejsí, V., Andera, L. J. Biol. Chem. (2002) [Pubmed]
  30. The size of the synaptic cleft and distinct distributions of filamentous actin, ezrin, CD43, and CD45 at activating and inhibitory human NK cell immune synapses. McCann, F.E., Vanherberghen, B., Eleme, K., Carlin, L.M., Newsam, R.J., Goulding, D., Davis, D.M. J. Immunol. (2003) [Pubmed]
  31. Down-regulation by tumor necrosis factor-alpha of neutrophil cell surface expression of the sialophorin CD43 and the hyaluronate receptor CD44 through a proteolytic mechanism. Campanero, M.R., Pulido, R., Alonso, J.L., Pivel, J.P., Pimentel-Muiños, F.X., Fresno, M., Sánchez-Madrid, F. Eur. J. Immunol. (1991) [Pubmed]
  32. Comparative analysis of T-cell costimulation and CD43 activation reveals novel signaling pathways and target genes. Mattioli, I., Dittrich-Breiholz, O., Livingstone, M., Kracht, M., Schmitz, M.L. Blood (2004) [Pubmed]
 
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