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Gene Review

Gypa  -  glycophorin A

Mus musculus

Synonyms: AI853584, CD235a, GPA, Glycophorin-A
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Disease relevance of Gypa


High impact information on Gypa

  • Lymphocytes bind to membranes containing the addressin, but not to phospholipid bilayers or to control glycophorin-reconstituted membranes [6].
  • Protein 4.1 forms a stable ternary complex with spectrin and actin, thereby strengthening the reticulum and anchoring it directly to the lipid bilayer or to another intrinsic protein, glycophorin [7].
  • Cells of one clone, Cl.Ly23/4, specifically bind glycophorin from sheep erythrocytes (SRBC) [8].
  • The liposomes were conjugated with either nonspecific mouse IgG, which interacts with an Fc receptor, or with monoclonal anti-human glycophorin, which interacts simultaneously with an Fc receptor and human glycophorin in the cell membrane [9].
  • Efficacy of drug delivery with liposomes directed both to the Fc receptor and to glycophorin A was not reduced by human IgG or soluble antiglycophorin A, but it was reduced twofold in the presence of both soluble ligands [9].

Chemical compound and disease context of Gypa


Biological context of Gypa


Anatomical context of Gypa


Associations of Gypa with chemical compounds


Physical interactions of Gypa


Regulatory relationships of Gypa


Other interactions of Gypa

  • The monoclonal antibody TER-119 recognizes a molecule associated with glycophorin A and specifically marks the late stages of murine erythroid lineage [24].
  • Mutation of tyrosine 569 to phenylalanine had no effect on the M-CSF-induced endocytosis of Fms, and a four-amino-acid sequence containing Y-569 could support endocytosis when transferred into the cytoplasmic juxtamembrane region of a glycophorin A construct [25].
  • The fusion gene containing the mouse C receptor 1-related gene/protein y (Crry) and a single chain Ab fragment with specificity for mouse glycophorin A was placed under transcriptional control of a liver-specific promoter [26].
  • The gene has been found to be encoded on four separate exons, and it thus differs from the cell surface mucin leukosialin, whose coding region is contained on one exon, but is similar to glycophorin and CD34, other cell surface mucins whose genes are divided into multiple coding exons [27].
  • The results indicated that HRCs could be defined by their expression of both transferrin receptors and glycophorin A [28].

Analytical, diagnostic and therapeutic context of Gypa


  1. Direct association of YY-1 with c-Myc and the E-box binding protein in regulation of glycophorin gene expression. Zhao, J.H., Inoue, T., Shoji, W., Nemoto, Y., Obinata, M. Oncogene (1998) [Pubmed]
  2. Synthesis and maturation of the erythrocyte anion transport protein--an internal sequence for membrane insertion. Lodish, H.F., Braell, W.A. Biochem. Soc. Symp. (1982) [Pubmed]
  3. Trypsin-sensitive, bovine serum albumin-dependent hemolysis activity in Mycoplasma pulmonis. Minion, F.C., Goguen, J.D. Infect. Immun. (1985) [Pubmed]
  4. Attachment of influenza C virus to human erythrocytes. Nishimura, H., Sugawara, K., Kitame, F., Nakamura, K. J. Gen. Virol. (1988) [Pubmed]
  5. Duffy antigen is important for the lethal effect of the lethal strain of Plasmodium yoelii 17XL. Akimitsu, N., Kim, H.S., Hamamoto, H., Kamura, K., Fukuma, N., Arimitsu, N., Ono, K., Wataya, Y., Torii, M., Sekimizu, K. Parasitol. Res. (2004) [Pubmed]
  6. The mucosal vascular addressin is a tissue-specific endothelial cell adhesion molecule for circulating lymphocytes. Nakache, M., Berg, E.L., Streeter, P.R., Butcher, E.C. Nature (1989) [Pubmed]
  7. Appearance of new variants of membrane skeletal protein 4.1 during terminal differentiation of avian erythroid and lenticular cells. Granger, B.L., Lazarides, E. Nature (1985) [Pubmed]
  8. Antigen-specific T lymphocyte clones. I. Characterization of a T lymphocyte clone expressing antigen-specific suppressive activity. Fresno, M., Nabel, G., McVay-Boudreau, L., Furthmayer, H., Cantor, H. J. Exp. Med. (1981) [Pubmed]
  9. Cytotoxicity of antibody-directed liposomes that recognize two receptors on K562 cells. Bragman, K.S., Heath, T.D., Papahadjopoulos, D. J. Natl. Cancer Inst. (1984) [Pubmed]
  10. Isolation of the cDNA clone for mouse glycophorin, erythroid-specific membrane protein. Matsui, Y., Natori, S., Obinata, M. Gene (1989) [Pubmed]
  11. Induction of glycophorin gene expression in cultured murine erythroleukemia cells. Matsui, Y., Natori, S., Obinata, M. Differentiation (1985) [Pubmed]
  12. Glycophorin A dimerization and band 3 interaction during erythroid membrane biogenesis: in vivo studies in human glycophorin A transgenic mice. Auffray, I., Marfatia, S., de Jong, K., Lee, G., Huang, C.H., Paszty, C., Tanner, M.J., Mohandas, N., Chasis, J.A. Blood (2001) [Pubmed]
  13. Mechanism of protein sorting during erythroblast enucleation: role of cytoskeletal connectivity. Lee, J.C., Gimm, J.A., Lo, A.J., Koury, M.J., Krauss, S.W., Mohandas, N., Chasis, J.A. Blood (2004) [Pubmed]
  14. Regulatory function of delta/YY-1 on the locus control region-like sequence of mouse glycophorin gene in erythroleukemia cells. Nemoto, Y., Terajima, M., Shoji, W., Obinata, M. J. Biol. Chem. (1996) [Pubmed]
  15. Glycophorin A requirement for expression of O-linked antigens on the erythrocyte membrane. Arimitsu, N., Akimitsu, N., Kotani, N., Takasaki, S., Kina, T., Hamamoto, H., Kamura, K., Sekimizu, K. Genes Cells (2003) [Pubmed]
  16. Complete deficiency of glycophorin A in red blood cells from mice with targeted inactivation of the band 3 (AE1) gene. Hassoun, H., Hanada, T., Lutchman, M., Sahr, K.E., Palek, J., Hanspal, M., Chishti, A.H. Blood (1998) [Pubmed]
  17. Erythrocyte membrane proteins reactive with IgG (warm-reacting) anti-red blood cell autoantibodies: II. Antibodies coprecipitating band 3 and glycophorin A. Leddy, J.P., Wilkinson, S.L., Kissel, G.E., Passador, S.T., Falany, J.L., Rosenfeld, S.I. Blood (1994) [Pubmed]
  18. Lectin-binding and spontaneous capping characteristics of the thymocyte glycophorin-like glycoprotein. de Petris, S. Exp. Cell Res. (1984) [Pubmed]
  19. Macrophage recognition of saccharide chains on the erythrocytes damaged by iron-catalyzed oxidation. Beppu, M., Takahashi, T., Kashiwada, M., Masukawa, S., Kikugawa, K. Arch. Biochem. Biophys. (1994) [Pubmed]
  20. Identification of murine erythrocyte autoantigens and cross-reactive rat antigens. Barker, R.N., Casswell, K.M., Elson, C.J. Immunology (1993) [Pubmed]
  21. Delineation of functional regions on Plasmodium falciparum EBA-175 by antibodies eluted from immune complexes. Sim, B.K. Mol. Biochem. Parasitol. (1998) [Pubmed]
  22. Recognition of sialosaccharide chains of glycophorin on damaged erythrocytes by macrophage scavenger receptors. Beppu, M., Hayashi, T., Hasegawa, T., Kikugawa, K. Biochim. Biophys. Acta (1995) [Pubmed]
  23. Loss of rotational mobility of band 3 proteins in human erythrocyte membranes induced by antibodies to glycophorin A. Che, A., Cherry, R.J. Biophys. J. (1995) [Pubmed]
  24. The monoclonal antibody TER-119 recognizes a molecule associated with glycophorin A and specifically marks the late stages of murine erythroid lineage. Kina, T., Ikuta, K., Takayama, E., Wada, K., Majumdar, A.S., Weissman, I.L., Katsura, Y. Br. J. Haematol. (2000) [Pubmed]
  25. Tyrosine 569 in the c-Fms juxtamembrane domain is essential for kinase activity and macrophage colony-stimulating factor-dependent internalization. Myles, G.M., Brandt, C.S., Carlberg, K., Rohrschneider, L.R. Mol. Cell. Biol. (1994) [Pubmed]
  26. Cutting edge: treatment of complement regulatory protein deficiency by retroviral in vivo gene therapy. Spitzer, D., Wu, X., Ma, X., Xu, L., Ponder, K.P., Atkinson, J.P. J. Immunol. (2006) [Pubmed]
  27. Structure and chromosomal localization of the murine gene encoding GLYCAM 1. A mucin-like endothelial ligand for L selectin. Dowbenko, D., Andalibi, A., Young, P.E., Lusis, A.J., Lasky, L.A. J. Biol. Chem. (1993) [Pubmed]
  28. Characterization of haemolyser-resistant cells increased in the blood of erythropoietin-treated mice. Said, A.A., Yamaguchi, T., Uchida, E., Hayakawa, T. Br. J. Haematol. (1994) [Pubmed]
  29. Full length mouse glycophorin gene constructed using recombinant polymerase chain reaction. Gu, H., Planas, J., Gómez, R., Wilson, D.J. Biochem. Biophys. Res. Commun. (1991) [Pubmed]
  30. Diverse specificities of five monoclonal antibodies reactive with glycophorin A of human erythrocytes. Ochiai, Y., Furthmayr, H., Marcus, D.M. J. Immunol. (1983) [Pubmed]
  31. Creatine kinase equilibration follows solution thermodynamics in skeletal muscle. 31P NMR studies using creatine analogs. Wiseman, R.W., Kushmerick, M.J. J. Biol. Chem. (1995) [Pubmed]
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