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Tff1  -  trefoil factor 1

Mus musculus

Synonyms: Bcei, PS2, Protein pS2, Ps2, Trefoil factor 1
 
 
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Disease relevance of Tff1

 

Psychiatry related information on Tff1

  • Mutations in genes encoding presenilins (PS1 and PS2) cosegregate with the majority of early onset cases of familial Alzheimer's disease [6].
 

High impact information on Tff1

 

Chemical compound and disease context of Tff1

  • Celecoxib (1600 ppm p.o. for 3 months) caused ulceration and inflammation of the adenoma in all treated TFF1(-/-) mice (n = 7) [2].
 

Biological context of Tff1

 

Anatomical context of Tff1

 

Associations of Tff1 with chemical compounds

  • The results demonstrated that only estradiol increased expression of the estrogen-responsive genes, c-myc, igf-1, cathepsin D, and pS2 mRNAs, in MCF-7E2 and MCF-7TAMLT tumors [17].
  • PS1 and PS2 are polytopic membrane proteins that undergo endoproteolytic cleavage to generate stable NH2- and COOH-terminal derivatives (NTF and CTF, respectively) [6].
  • In fact, basal pS2 mRNA levels are elevated 2.8 +/- 0.4-fold in MCF-7 K3 cells, and E2 evokes a concentration-dependent suppression of the pS2 mRNA level [18].
  • EM-652 is also very effective in abrogating E2-stimulated ER alpha and ER beta trans-activation of the pS2 promoter in HeLa cells [19].
  • Additionally, the expression of intestinal genes involved in epithelial protection were analyzed: the mucus layer glycoprotein muclin, the polymeric Ig receptor, trefoil factor 3, and small proline-rich protein 2a (sprr2a) [20].
 

Regulatory relationships of Tff1

  • Nonneoplastic gastrointestinal tissues of wild-type or TFF1(-/-) mice expressed low or nondetectable levels of Cox-2 [2].
 

Other interactions of Tff1

 

Analytical, diagnostic and therapeutic context of Tff1

References

  1. Expression of tight-junction protein claudin-7 is an early event in gastric tumorigenesis. Johnson, A.H., Frierson, H.F., Zaika, A., Powell, S.M., Roche, J., Crowe, S., Moskaluk, C.A., El-Rifai, W. Am. J. Pathol. (2005) [Pubmed]
  2. Cyclooxygenase-2 expression and effect of celecoxib in gastric adenomas of trefoil factor 1-deficient mice. Saukkonen, K., Tomasetto, C., Narko, K., Rio, M.C., Ristimäki, A. Cancer Res. (2003) [Pubmed]
  3. The mouse one P-domain (pS2) and two P-domain (mSP) genes exhibit distinct patterns of expression. Lefebvre, O., Wolf, C., Kédinger, M., Chenard, M.P., Tomasetto, C., Chambon, P., Rio, M.C. J. Cell Biol. (1993) [Pubmed]
  4. Expression of trefoil peptides in the gastric mucosa of transgenic mice overexpressing transforming growth factor-alpha. Goldenring, J.R., Poulsom, R., Ray, G.S., Wright, N., Meise, K.S., Coffey, R.J. Growth Factors (1996) [Pubmed]
  5. Estrogen suppression of erbB2 expression is associated with increased growth rate of ZR-75-1 human breast cancer cells in vitro and in nude mice. Wärri, A.M., Laine, A.M., Majasuo, K.E., Alitalo, K.K., Härkönen, P.L. Int. J. Cancer (1991) [Pubmed]
  6. Evidence that intramolecular associations between presenilin domains are obligatory for endoproteolytic processing. Saura, C.A., Tomita, T., Davenport, F., Harris, C.L., Iwatsubo, T., Thinakaran, G. J. Biol. Chem. (1999) [Pubmed]
  7. Gastric mucosa abnormalities and tumorigenesis in mice lacking the pS2 trefoil protein. Lefebvre, O., Chenard, M.P., Masson, R., Linares, J., Dierich, A., LeMeur, M., Wendling, C., Tomasetto, C., Chambon, P., Rio, M.C. Science (1996) [Pubmed]
  8. Selective coactivation of estrogen-dependent transcription by CITED1 CBP/p300-binding protein. Yahata, T., Shao, W., Endoh, H., Hur, J., Coser, K.R., Sun, H., Ueda, Y., Kato, S., Isselbacher, K.J., Brown, M., Shioda, T. Genes Dev. (2001) [Pubmed]
  9. Muc2-deficient mice spontaneously develop colitis, indicating that MUC2 is critical for colonic protection. Van der Sluis, M., De Koning, B.A., De Bruijn, A.C., Velcich, A., Meijerink, J.P., Van Goudoever, J.B., Büller, H.A., Dekker, J., Van Seuningen, I., Renes, I.B., Einerhand, A.W. Gastroenterology (2006) [Pubmed]
  10. Trefoil factor family-1 mutations enhance gastric cancer cell invasion through distinct signaling pathways. Yio, X., Diamond, M., Zhang, J.Y., Weinstein, H., Wang, L.H., Werther, L., Itzkowitz, S. Gastroenterology (2006) [Pubmed]
  11. Transcriptional regulation of the human trefoil factor, TFF1, by gastrin. Khan, Z.E., Wang, T.C., Cui, G., Chi, A.L., Dimaline, R. Gastroenterology (2003) [Pubmed]
  12. Mouse Trefoil factor genes: genomic organization, sequences and methylation analyses. Ribieras, S., Lefèbvre, O., Tomasetto, C., Rio, M.C. Gene (2001) [Pubmed]
  13. Characterization of the mouse TFF1 (pS2) gene promoter region. Terada, T., Sakagami, R., Tabuchi, Y., Maeda, M. Biol. Pharm. Bull. (2001) [Pubmed]
  14. Loss of heterozygosity and promoter methylation, but not mutation, may underlie loss of TFF1 in gastric carcinoma. Carvalho, R., Kayademir, T., Soares, P., Canedo, P., Sousa, S., Oliveira, C., Leistenschneider, P., Seruca, R., Gött, P., Blin, N., Carneiro, F., Machado, J.C. Lab. Invest. (2002) [Pubmed]
  15. Effect of ectopic expression of rat trefoil factor family 3 (intestinal trefoil factor) in the jejunum of transgenic mice. Marchbank, T., Cox, H.M., Goodlad, R.A., Giraud, A.S., Moss, S.F., Poulsom, R., Wright, N.A., Jankowski, J., Playford, R.J. J. Biol. Chem. (2001) [Pubmed]
  16. Resistance of human breast-cancer cells to the pure steroidal anti-estrogen ICI 182,780 is not associated with a general loss of estrogen-receptor expression or lack of estrogen responsiveness. Larsen, S.S., Madsen, M.W., Jensen, B.L., Lykkesfeldt, A.E. Int. J. Cancer (1997) [Pubmed]
  17. Role for HER2/neu and HER3 in fulvestrant-resistant breast cancer. Osipo, C., Meeke, K., Cheng, D., Weichel, A., Bertucci, A., Liu, H., Jordan, V.C. Int. J. Oncol. (2007) [Pubmed]
  18. Differential regulation of gene expression by estrogen in estrogen growth-independent and -dependent MCF-7 human breast cancer cell sublines. Cho, H.S., NG, P.A., Katzenellenbogen, B.S. Mol. Endocrinol. (1991) [Pubmed]
  19. EM-800, a novel antiestrogen, acts as a pure antagonist of the transcriptional functions of estrogen receptors alpha and beta. Tremblay, A., Tremblay, G.B., Labrie, C., Labrie, F., Giguère, V. Endocrinology (1998) [Pubmed]
  20. Decreased gastric bacterial killing and up-regulation of protective genes in small intestine in gastrin-deficient mouse. Sun, F.J., Kaur, S., Ziemer, D., Banerjee, S., Samuelson, L.C., De Lisle, R.C. Dig. Dis. Sci. (2003) [Pubmed]
  21. Magnetic resonance imaging of gastric cancer in Tff1 knock-out mice. Berr, S.S., Roche, J.K., El-Rifai, W., Smith, M.F., Powell, S.M. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. (2003) [Pubmed]
  22. Dissecting asthma using focused transgenic modeling and functional genomics. Kuperman, D.A., Lewis, C.C., Woodruff, P.G., Rodriguez, M.W., Yang, Y.H., Dolganov, G.M., Fahy, J.V., Erle, D.J. J. Allergy Clin. Immunol. (2005) [Pubmed]
  23. Regulation of estrogen target genes and growth by selective estrogen-receptor modulators in endometrial cancer cells. Dardes, R.C., Schafer, J.M., Pearce, S.T., Osipo, C., Chen, B., Jordan, V.C. Gynecol. Oncol. (2002) [Pubmed]
 
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