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MeSH Review

Pyloric Antrum

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Disease relevance of Pyloric Antrum


Psychiatry related information on Pyloric Antrum


High impact information on Pyloric Antrum


Chemical compound and disease context of Pyloric Antrum


Biological context of Pyloric Antrum


Anatomical context of Pyloric Antrum


Associations of Pyloric Antrum with chemical compounds


Gene context of Pyloric Antrum

  • Gastrin is a hormone produced by G-cells in the normal gastric antrum [29].
  • We obtained endoscopic pinch biopsies of, and extracted the RNA from, epithelial cells lining the esophagus, stomach, jejunum, ileum, and proximal and descending colon, RT-PCR demonstrated that GRP-R expression is limited to cells lining the gastric antrum, indicating that this receptor is aberrantly expressed by GI cancers [30].
  • SP predominates in the gastric antrum as a 12 kDa form [31].
  • This study aimed to determine the distribution of MUC 5 and MUC 6 in the gastric antrum of dyspeptic patients, and to investigate changes in this pattern in the presence of H. pylori and after successful eradication [32].
  • METHODS: Biopsy specimens obtained from the gastric antrum and corpus of H. pylori-infected (n = 13) and noninfected children (n = 15) were studied for immunolocalization of Ki-67, single-strand DNA, manganese superoxide dismutase (Mn-SOD), and CD68, and terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick-end labeling [33].

Analytical, diagnostic and therapeutic context of Pyloric Antrum


  1. Recurrent peptic ulcer. Stabile, B.E., Passaro, E. Gastroenterology (1976) [Pubmed]
  2. Neutrophil degranulation by Helicobacter pylori proteins. Nøorgaard, A., Andersen, L.P., Nielsen, H. Gut (1995) [Pubmed]
  3. Action of neurotensin on size, composition, and growth of pancreas and stomach in the rat. Feurle, G.E., Müller, B., Ohnheiser, G., Baća, I. Regul. Pept. (1985) [Pubmed]
  4. Changing pattern of cytokeratin 7 and 20 expression from normal epithelium to intestinal metaplasia of the gastric mucosa and gastroesophageal junction. Jovanovic, I., Tzardi, M., Mouzas, I.A., Micev, M., Pesko, P., Milosavljevic, T., Zois, M., Sganzos, M., Delides, G., Kanavaros, P. Histol. Histopathol. (2002) [Pubmed]
  5. Non-Helicobacter pylori ulcer disease in rheumatoid arthritis patients receiving long-term NSAID therapy. Mizokami, Y., Narushima, K., Shiraishi, T., Otsubo, T., Narasaka, T., Matsuoka, T. J. Gastroenterol. (2000) [Pubmed]
  6. Inter-digestive and post-prandial antro-pyloro-duodenal motor activity in humans: effect of 5-hydroxytryptamine 1 receptor agonism. Calvert, E.L., Whorwell, P.J., Houghton, L.A. Aliment. Pharmacol. Ther. (2004) [Pubmed]
  7. A new prosomatostatin-derived peptide reveals a pattern for prohormone cleavage at monobasic sites. Benoit, R., Ling, N., Esch, F. Science (1987) [Pubmed]
  8. Prosomatostatin-derived antrin is present in gastric D cells and in portal blood. Ravazzola, M., Benoit, R., Ling, N., Orci, L. J. Clin. Invest. (1989) [Pubmed]
  9. Increased expression and cellular localization of inducible nitric oxide synthase and cyclooxygenase 2 in Helicobacter pylori gastritis. Fu, S., Ramanujam, K.S., Wong, A., Fantry, G.T., Drachenberg, C.B., James, S.P., Meltzer, S.J., Wilson, K.T. Gastroenterology (1999) [Pubmed]
  10. How does Helicobacter pylori cause mucosal damage? Its effect on acid and gastrin physiology. Calam, J., Gibbons, A., Healey, Z.V., Bliss, P., Arebi, N. Gastroenterology (1997) [Pubmed]
  11. Somatostatin receptor subtype 2 mediates inhibition of gastrin and histamine secretion from human, dog, and rat antrum. Zaki, M., Harrington, L., McCuen, R., Coy, D.H., Arimura, A., Schubert, M.L. Gastroenterology (1996) [Pubmed]
  12. Enhancement by KW-5092, a novel gastroprokinetic agent, of the gastrointestinal motor activity in dogs. Kishibayashi, N., Tomaru, A., Ichikawa, S., Kitazawa, T., Shuto, K., Ishii, A., Karasawa, A. Jpn. J. Pharmacol. (1994) [Pubmed]
  13. Gastrogastric intussuscepting leiomyomas. Grundy, A., Rayter, Z., Shorthouse, A.J. Gastrointestinal radiology. (1984) [Pubmed]
  14. Ursodeoxycholic acid does not interfere with in vivo Helicobacter pylori colonization. Silva, J.G., Zeitune, J.M., Sipahi, A.M., Iryia, K., Laudanna, A.A. Revista do Hospital das Clínicas. (2000) [Pubmed]
  15. Properties of gastric smooth muscles obtained from mice which lack inositol trisphosphate receptor. Suzuki, H., Takano, H., Yamamoto, Y., Komuro, T., Saito, M., Kato, K., Mikoshiba, K. J. Physiol. (Lond.) (2000) [Pubmed]
  16. Temporal profiles of urinary excretion of NH2-terminal big gastrin immunoreactivity in humans. Nagao, K., Higashimoto, Y., Shinomura, Y., Himeno, S., Miyazaki, Y., Yasunaga, Y., Tarui, S. Am. J. Gastroenterol. (1990) [Pubmed]
  17. Gastric emptying after different surgical procedures for duodenal ulcer. Faxén, A., Berger, T., Kewenter, J., Kock, N.G. Scand. J. Gastroenterol. (1977) [Pubmed]
  18. Regulation of gastric somatostatin gene expression. Wu, S.V., Sumii, K., Tari, A., Mogard, M., Walsh, J.H. Metab. Clin. Exp. (1990) [Pubmed]
  19. Function and regulation of gastrin in transgenic mice: a review. Wang, T.C., Brand, S.J. The Yale journal of biology and medicine. (1992) [Pubmed]
  20. Indomethacin produces gastric antral ulcers in the refed rat. Satoh, H., Inada, I., Hirata, T., Maki, Y. Gastroenterology (1981) [Pubmed]
  21. Gastrin, CCK, signaling, and cancer. Rozengurt, E., Walsh, J.H. Annu. Rev. Physiol. (2001) [Pubmed]
  22. Tumors in hepatobiliary tract and pancreatic islet tissues of transgenic mice harboring gastrin simian virus 40 large tumor antigen fusion gene. Montag, A.G., Oka, T., Baek, K.H., Choi, C.S., Jay, G., Agarwal, K. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  23. Mechanisms of action of peripherally administered cholecystokinin octapeptide on brain stem neurons in the rat. Raybould, H.E., Gayton, R.J., Dockray, G.J. J. Neurosci. (1988) [Pubmed]
  24. Role of bacteria in gastric ulceration produced by indomethacin in the rat: cytoprotective action of antibiotics. Satoh, H., Guth, P.H., Grossman, M.I. Gastroenterology (1983) [Pubmed]
  25. Gastrointestinal motor effects of erythromycin in humans. Sarna, S.K., Soergel, K.H., Koch, T.R., Stone, J.E., Wood, C.M., Ryan, R.P., Arndorfer, R.C., Cavanaugh, J.H., Nellans, H.N., Lee, M.B. Gastroenterology (1991) [Pubmed]
  26. Polyacrylamide gel electrophoresis of spiral bacteria from the gastric antrum. Pearson, A.D., Ireland, A., Bamforth, J., Walker, C., Booth, L., Hawtin, P., Holdstock, G., Millward-Sadler, H. Lancet (1984) [Pubmed]
  27. Expression of the gastrin gene in the normal human colon and colorectal adenocarcinoma. Finley, G.G., Koski, R.A., Melhem, M.F., Pipas, J.M., Meisler, A.I. Cancer Res. (1993) [Pubmed]
  28. Detection of the intragastric sites at which Helicobacter pylori evades treatment with amoxycillin and cimetidine. Atherton, J.C., Cockayne, A., Balsitis, M., Kirk, G.E., Hawkey, C.J., Spiller, R.C. Gut (1995) [Pubmed]
  29. Gastrin stimulates cyclooxygenase-2 expression in intestinal epithelial cells through multiple signaling pathways. Evidence for involvement of ERK5 kinase and transactivation of the epidermal growth factor receptor. Guo, Y.S., Cheng, J.Z., Jin, G.F., Gutkind, J.S., Hellmich, M.R., Townsend, C.M. J. Biol. Chem. (2002) [Pubmed]
  30. Location and characterization of the human GRP receptor expressed by gastrointestinal epithelial cells. Ferris, H.A., Carroll, R.E., Lorimer, D.L., Benya, R.V. Peptides (1997) [Pubmed]
  31. The trefoil peptides spasmolytic polypeptide and intestinal trefoil factor are major secretory products of the rat gut. Taupin, D.R., Pang, K.C., Green, S.P., Giraud, A.S. Peptides (1995) [Pubmed]
  32. Does Helicobacter pylori affect gastric mucin expression? Relationship between gastric antral mucin expression and H. pylori colonization. Morgenstern, S., Koren, R., Moss, S.F., Fraser, G., Okon, E., Niv, Y. European journal of gastroenterology & hepatology. (2001) [Pubmed]
  33. Gastric epithelial cell turnover and mucosal protection in Japanese children with Helicobacter pylori infection. Ozawa, K., Kato, S., Sekine, H., Koike, T., Minoura, T., Iinuma, K., Nagura, H. J. Gastroenterol. (2005) [Pubmed]
  34. Gastric ulcer formation and cyclo-oxygenase inhibition in cat antrum follows parenteral administration of aspirin but not salicylate. Whittle, B.J., Hansen, D., Salmon, J.A. Eur. J. Pharmacol. (1985) [Pubmed]
  35. Chemoneurolysis of the canine gastric submucosa. Effects on surgically-induced gastric hypersecretion on the Heidenhain pouch. Schapiro, H., Jackson, N.J., Rosato, F.E., Chaudhuri, T.K., Gayle, R.G. The American surgeon. (1978) [Pubmed]
  36. Immunohistochemistry and morphometry of gastrin cells in the rat pyloric antrum during starvation. Oomori, Y. Anat. Embryol. (1986) [Pubmed]
  37. Erosive duodenitis: prevalence of Helicobacter pylori infection and response to eradication therapy with omeprazole plus two antibiotics. Gisbert, J.P., Boixeda, D., de Argila, C.M., Bermejo, F., Redondo, C., de Rafael, L. European journal of gastroenterology & hepatology. (1997) [Pubmed]
  38. Cell proliferation of the rat gastrointestinal mucosa after treatment with E2 prostaglandins and indomethacin. Uribe, A., Johansson, C., Rubio, C. Digestion (1987) [Pubmed]
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