Gene Review:
HMGCS1 - 3-hydroxy-3-methylglutaryl-CoA synthase 1...
Homo sapiens
Synonyms:
3-hydroxy-3-methylglutaryl coenzyme A synthase, HMG-CoA synthase, HMGCS, Hydroxymethylglutaryl-CoA synthase, cytoplasmic
- Rat mitochondrial and cytosolic 3-hydroxy-3-methylglutaryl-CoA synthases are encoded by two different genes. Ayté, J., Gil-Gómez, G., Haro, D., Marrero, P.F., Hegardt, F.G. Proc. Natl. Acad. Sci. U.S.A. (1990)
- 3-hydroxy-3-methylglutaryl-coenzyme A synthase reaction intermediates: detection of a covalent tetrahedral adduct by differential isotope shift 13C nuclear magnetic resonance spectroscopy. Vinarov, D.A., Miziorko, H.M. Biochemistry (2000)
- 3-Hydroxy-3-methylglutaryl-coenzyme A (CoA) synthase is involved in biosynthesis of isovaleryl-CoA in the myxobacterium Myxococcus xanthus during fruiting body formation. Bode, H.B., Ring, M.W., Schwär, G., Kroppenstedt, R.M., Kaiser, D., Müller, R. J. Bacteriol. (2006)
- The molecular mechanism of the induction of the low density lipoprotein receptor by chenodeoxycholic acid in cultured human cells. Kawabe, Y., Shimokawa, T., Matsumoto, A., Honda, M., Wada, Y., Yazaki, Y., Endo, A., Itakura, H., Kodama, T. Biochem. Biophys. Res. Commun. (1995)
- Cholesterol metabolism and colon cancer. Broitman, S.A., Cerda, S., Wilkinson, J. Progress in food & nutrition science. (1993)
- SREBP-2, a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element. Hua, X., Yokoyama, C., Wu, J., Briggs, M.R., Brown, M.S., Goldstein, J.L., Wang, X. Proc. Natl. Acad. Sci. U.S.A. (1993)
- Common double- and single-stranded DNA binding factor for a sterol regulatory element. Stark, H.C., Weinberger, O., Weinberger, J. Proc. Natl. Acad. Sci. U.S.A. (1992)
- Optional exon in the 5'-untranslated region of 3-hydroxy-3-methylglutaryl coenzyme A synthase gene: conserved sequence and splicing pattern in humans and hamsters. Gil, G., Smith, J.R., Goldstein, J.L., Brown, M.S. Proc. Natl. Acad. Sci. U.S.A. (1987)
- Localization of the gene encoding 3-hydroxy-3-methylglutaryl-coenzyme A synthase to human chromosome 5. Leonard, S., Arbogast, D., Geyer, D., Jones, C., Sinensky, M. Proc. Natl. Acad. Sci. U.S.A. (1986)
- Transcriptional downregulation of sterol metabolism genes in murine liver exposed to acute hypobaric hypoxia. Dolt, K.S., Karar, J., Mishra, M.K., Salim, J., Kumar, R., Grover, S.K., Qadar Pasha, M.A. Biochem. Biophys. Res. Commun. (2007)
- Autocrine platelet-derived growth factor-dependent gene expression in glioblastoma cells is mediated largely by activation of the transcription factor sterol regulatory element binding protein and is associated with altered genotype and patient survival in human brain tumors. Ma, D., Nutt, C.L., Shanehsaz, P., Peng, X., Louis, D.N., Kaetzel, D.M. Cancer Res. (2005)
- Peroxisome proliferator-activated receptor mediates induction of the mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene by fatty acids. Rodríguez, J.C., Gil-Gómez, G., Hegardt, F.G., Haro, D. J. Biol. Chem. (1994)
- Regulation of rat liver 3-hydroxy-3-methylglutaryl coenzyme A synthase and the chromosomal localization of the human gene. Mehrabian, M., Callaway, K.A., Clarke, C.F., Tanaka, R.D., Greenspan, M., Lusis, A.J., Sparkes, R.S., Mohandas, T., Edmond, J., Fogelman, A.M. J. Biol. Chem. (1986)
- Transfection of the ketogenic mitochondrial 3-hydroxy-3-methylglutaryl-coenzyme A synthase cDNA into Mev-1 cells corrects their auxotrophy for mevalonate. Ortiz, J.A., Gil-Gómez, G., Casaroli-Marano, R.P., Vilaró, S., Hegardt, F.G., Haro, D. J. Biol. Chem. (1994)
- Genetic distinction between sterol-mediated transcriptional and posttranscriptional control of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. Dawson, P.A., Metherall, J.E., Ridgway, N.D., Brown, M.S., Goldstein, J.L. J. Biol. Chem. (1991)
- Regulation of HMG-CoA synthase and HMG-CoA reductase by insulin and epidermal growth factor in HaCaT keratinocytes. Harris, I.R., Höppner, H., Siefken, W., Farrell, A.M., Wittern, K.P. J. Invest. Dermatol. (2000)
- Identification of peroxisomal targeting signals in cholesterol biosynthetic enzymes. AA-CoA thiolase, hmg-coa synthase, MPPD, and FPP synthase. Olivier, L.M., Kovacs, W., Masuda, K., Keller, G.A., Krisans, S.K. J. Lipid Res. (2000)
- Isolation and sequence of the human farnesyl pyrophosphate synthetase cDNA. Coordinate regulation of the mRNAs for farnesyl pyrophosphate synthetase, 3-hydroxy-3-methylglutaryl coenzyme A reductase, and 3-hydroxy-3-methylglutaryl coenzyme A synthase by phorbol ester. Wilkin, D.J., Kutsunai, S.Y., Edwards, P.A. J. Biol. Chem. (1990)
- Calcium ionophore treatment impairs the sterol-mediated suppression of 3-hydroxy-3-methylglutaryl-coenzyme A reductase, 3-hydroxy-3-methylglutaryl-coenzyme A synthase, and farnesyl diphosphate synthetase. Wilkin, D.J., Edwards, P.A. J. Biol. Chem. (1992)
- Polyunsaturated fatty acids decrease expression of promoters with sterol regulatory elements by decreasing levels of mature sterol regulatory element-binding protein. Worgall, T.S., Sturley, S.L., Seo, T., Osborne, T.F., Deckelbaum, R.J. J. Biol. Chem. (1998)
- Multiple DNA elements for sterol regulatory element-binding protein and NF-Y are responsible for sterol-regulated transcription of the genes for human 3-hydroxy-3-methylglutaryl coenzyme A synthase and squalene synthase. Inoue, J., Sato, R., Maeda, M. J. Biochem. (1998)
- A critical role for cAMP response element-binding protein (CREB) as a Co-activator in sterol-regulated transcription of 3-hydroxy-3-methylglutaryl coenzyme A synthase promoter. Dooley, K.A., Bennett, M.K., Osborne, T.F. J. Biol. Chem. (1999)
- Variations in the mRNA expression of inflammatory mediators, markers of differentiation and lipid-metabolizing enzymes caused by sodium lauryl sulphate in cultured human keratinocytes. Törmä, H., Geijer, S., Gester, T., Alpholm, K., Berne, B., Lindberg, M. Toxicology in vitro : an international journal published in association with BIBRA. (2006)
- Cafestol, the cholesterol-raising factor in boiled coffee, suppresses bile acid synthesis by downregulation of cholesterol 7 alpha-hydroxylase and sterol 27-hydroxylase in rat hepatocytes. Post, S.M., de Wit, E.C., Princen, H.M. Arterioscler. Thromb. Vasc. Biol. (1997)
- Discordant regulation of proteins of cholesterol metabolism during the acute phase response. Feingold, K.R., Pollock, A.S., Moser, A.H., Shigenaga, J.K., Grunfeld, C. J. Lipid Res. (1995)
- YY1 is a negative regulator of transcription of three sterol regulatory element-binding protein-responsive genes. Ericsson, J., Usheva, A., Edwards, P.A. J. Biol. Chem. (1999)
- The inhibition of cytoplasmic acetoacetyl-CoA thiolase by a triyne carbonate (L-660, 631). Greenspan, M.D., Yudkovitz, J.B., Chen, J.S., Hanf, D.P., Chang, M.N., Chiang, P.Y., Chabala, J.C., Alberts, A.W. Biochem. Biophys. Res. Commun. (1989)
- Differential regulation of the expression of 3-hydroxy-3-methylglutaryl coenzyme A reductase, synthase, and low density lipoprotein receptor genes. Cuthbert, J.A., Lipsky, P.E. J. Lipid Res. (1992)