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Gene Review

Cstb  -  cystatin B (stefin B)

Rattus norvegicus

Synonyms: Cst6, Cyb, Cystatin-B, Cystatin-beta, Epm1, ...
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Disease relevance of Cstb

  • To understand the bone resorption and lysosomal proteinases in osteoclasts, we examined by immunohistochemistry the localization of lysosomal cysteine and aspartic proteinases, acid phosphatase, and cystatin-beta in the rat tibial bone [1].
  • Materials and methods Thirty-two adult, female Wistar EPM-1 rats (body weight 200-220 g) were divided into four equal groups that underwent; group 1, no treatment (controls); group 2, a sham operation; group 3, antrectomy; and group 4, antrocystoplasty [2].
  • Sixteen male Wistar rats (EPM-1) were submitted to an 80% small bowel resection associated with a partial colectomy of the distal colon immediately after the bifurcation of the middle colic artery followed by a 3-cm isoperistaltic distal colon interposition [3].

Psychiatry related information on Cstb


High impact information on Cstb


Biological context of Cstb

  • Mice with a gene deletion of CSTB exhibit increased apoptosis of specific neurons but the physiological role of CSTB in brain cells is not fully understood [7].
  • For the MN assay, the cytokinesis block induced by cytochalasin B (CYB) was employed to enumerate MN in binucleated (BN) cells [8].
  • To analyze the degradation system in epidermal cells during their generation, differentiation, and cell death, immunocytochemical localization of lysosomal cysteine and aspartic proteinases, an endogenous cysteine proteinase inhibitor, cystatin beta, and ubiquitin were examined using rat sole skin [9].

Anatomical context of Cstb

  • CSTB was expressed by both neurons and glial cells differentiated from NSC and in hippocampal cultures [7].
  • In the present study, we have examined the expression of CSTB in neural stem cells (NSC) and in differentiating mature brain cells [7].
  • CSTB localized mainly to the nucleus in NSC and in neurons, whilst in astrocytes CSTB was also in the cytoplasm [7].
  • Double labeling showed that CSTB was present in the lysosomes in glial cells [7].
  • A new stefin B-type low-Mr CPI was isolated from bovine thymus and subjected to structural analysis [10].

Associations of Cstb with chemical compounds


Other interactions of Cstb


Analytical, diagnostic and therapeutic context of Cstb


  1. Lysosomal cysteine and aspartic proteinases, acid phosphatase, and an endogenous cysteine proteinase inhibitor, cystatin-beta, in rat osteoclasts. Ohsawa, Y., Nitatori, T., Higuchi, S., Kominami, E., Uchiyama, Y. J. Histochem. Cytochem. (1993) [Pubmed]
  2. Gastrinaemia and G-cell density in the antral gastrocystoplasty: an experimental study in rats. Ortiz, V., Goldenberg, S. BJU international. (2000) [Pubmed]
  3. Evaluation of the longitudinal musculature of segments of the distal colon interposed following extended jejunum-ileum resection. Taha, M.O., Ribeiro, M.A., de Oliveira Gomes, P., Montero Frasson, E., Plapler, H., Ferreira, R., Lapa, A.J., Soucar, C. Microsurgery. (1999) [Pubmed]
  4. Comparison of anxiety measured in the elevated plus-maze, open-field and social interaction tests between spontaneously hypertensive rats and Wistar EPM-1 rats. Goto, S.H., Conceição, I.M., Ribeiro, R.A., Frussa-Filho, R. Braz. J. Med. Biol. Res. (1993) [Pubmed]
  5. Seizures induce widespread upregulation of cystatin B, the gene mutated in progressive myoclonus epilepsy, in rat forebrain neurons. D'Amato, E., Kokaia, Z., Nanobashvili, A., Reeben, M., Lehesjoki, A.E., Saarma, M., Lindvall, O. Eur. J. Neurosci. (2000) [Pubmed]
  6. Structural organization of the gene encoding rat cystatin beta. Sato, N., Ishidoh, K., Uchiyama, Y., Kominami, E. Gene (1992) [Pubmed]
  7. Cystatin-B is expressed by neural stem cells and by differentiated neurons and astrocytes. Brännvall, K., Hjelm, H., Korhonen, L., Lahtinen, U., Lehesjoki, A.E., Lindholm, D. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  8. Use of rat primary lung cells for studying genotoxicity with the sister-chromatid exchange and micronucleus assays. Whong, W.Z., Stewart, J.D., Ong, T. Mutat. Res. (1990) [Pubmed]
  9. Immunocytochemical localization of lysosomal cysteine and aspartic proteinases, and ubiquitin in rat epidermis. Sato, K., Waguri, S., Ohsawa, Y., Nitatori, T., Kon, S., Kominami, E., Watanabe, T., Gotow, T., Uchiyama, Y. Arch. Histol. Cytol. (1997) [Pubmed]
  10. The complete primary structure of bovine stefin B. Krizaj, I., Turk, B., Turk, V. FEBS Lett. (1992) [Pubmed]
  11. Formation of mixed disulfide of cystatin-beta in cultured macrophages treated with various oxidants. Tsukahara, T., Kominami, E., Katunuma, N. J. Biochem. (1987) [Pubmed]
  12. Expression of cysteine proteinases and their inhibitor, cystatin beta, in cultured rat mesangial cells. Makita, Y., Ishidoh, K., Kominami, E., Funabiki, K., Koide, H., Tomino, Y. J. Diabetes Complicat. (1998) [Pubmed]
  13. Biochemical and morphological evaluation of ischemia-reperfusion injury in rat small bowel modulated by ischemic preconditioning. Abrahão, M.S., Montero, E.F., Junqueira, V.B., Giavarotti, L., Juliano, Y., Fagundes, D.J. Transplant. Proc. (2004) [Pubmed]
  14. Immunocytochemical localization of cathepsins B and H in corticotrophs and melanotrophs of rat pituitary gland. Uchiyama, Y., Nakajima, M., Muno, D., Watanabe, T., Ishii, Y., Waguri, S., Sato, N., Kominami, E. J. Histochem. Cytochem. (1990) [Pubmed]
  15. Molecular cloning and sequencing of cDNA for rat cystatin beta. Sato, N., Ishidoh, K., Uchiyama, Y., Kominami, E. Nucleic Acids Res. (1990) [Pubmed]
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