Gene Review:
TXN2 - thioredoxin 2
Homo sapiens
Synonyms:
MT-TRX, MTRX, Mt-Trx, TRX2, Thioredoxin, mitochondrial, ...
- Permutation of the active site motif of tryparedoxin 2. Steinert, P., Plank-Schumacher, K., Montemartini, M., Hecht, H.J., Flohé, L. Biol. Chem. (2000)
- Thiol-related genes in diabetic complications: a novel protective role for endogenous thioredoxin 2. Liang, M., Pietrusz, J.L. Arterioscler. Thromb. Vasc. Biol. (2007)
- Role of the thioredoxin system and the thiol-peroxidases Tpx and Bcp in mediating resistance to oxidative and nitrosative stress in Helicobacter pylori. Comtois, S.L., Gidley, M.D., Kelly, D.J. Microbiology (Reading, Engl.) (2003)
- Thioredoxin 1 and thioredoxin 2 have opposed regulatory functions on hypoxia-inducible factor-1alpha. Zhou, J., Damdimopoulos, A.E., Spyrou, G., Brüne, B. J. Biol. Chem. (2007)
- Thioredoxin-2 (TRX-2) is an essential gene regulating mitochondria-dependent apoptosis. Tanaka, T., Hosoi, F., Yamaguchi-Iwai, Y., Nakamura, H., Masutani, H., Ueda, S., Nishiyama, A., Takeda, S., Wada, H., Spyrou, G., Yodoi, J. EMBO J. (2002)
- Human mitochondrial thioredoxin. Involvement in mitochondrial membrane potential and cell death. Damdimopoulos, A.E., Miranda-Vizuete, A., Pelto-Huikko, M., Gustafsson, J.A., Spyrou, G. J. Biol. Chem. (2002)
- Mitochondrial thioredoxin-2 has a key role in determining tumor necrosis factor-alpha-induced reactive oxygen species generation, NF-kappaB activation, and apoptosis. Hansen, J.M., Zhang, H., Jones, D.P. Toxicol. Sci. (2006)
- Distinct glucose-dependent stress responses revealed by translational profiling in pancreatic {beta}-cells. Greenman, I.C., Gomez, E., Moore, C.E., Herbert, T.P. J. Endocrinol. (2007)
- Crystal structures of oxidized and reduced forms of human mitochondrial thioredoxin 2. Smeets, A., Evrard, C., Landtmeters, M., Marchand, C., Knoops, B., Declercq, J.P. Protein Sci. (2005)
- The thioredoxin system in aging muscle: key role of mitochondrial thioredoxin reductase in the protective effects of caloric restriction? Rohrbach, S., Gruenler, S., Teschner, M., Holtz, J. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2006)
- Evidence for an age-related attenuation of cerebral microvascular antioxidant response to oxidative stress. Williams, W.M., Chung, Y.W. Life Sci. (2006)
- Differential oxidation of thioredoxin-1, thioredoxin-2, and glutathione by metal ions. Hansen, J.M., Zhang, H., Jones, D.P. Free Radic. Biol. Med. (2006)
- Involvements of mitochondrial thioredoxin reductase (TrxR2) in cell proliferation. Kim, M.R., Chang, H.S., Kim, B.H., Kim, S., Baek, S.H., Kim, J.H., Lee, S.R., Kim, J.R. Biochem. Biophys. Res. Commun. (2003)
- Thioredoxin-2 inhibits mitochondria-located ASK1-mediated apoptosis in a JNK-independent manner. Zhang, R., Al-Lamki, R., Bai, L., Streb, J.W., Miano, J.M., Bradley, J., Min, W. Circ. Res. (2004)
- Gene expression profiling reveals complex changes following MEK-EE expression in cardiac myocytes. Badrian, B., Bogoyevitch, M.A. Int. J. Biochem. Cell Biol. (2007)
- Molecular and cellular characterization of imexon-resistant RPMI8226/I myeloma cells. Dvorakova, K., Payne, C.M., Tome, M.E., Briehl, M.M., Vasquez, M.A., Waltmire, C.N., Coon, A., Dorr, R.T. Mol. Cancer Ther. (2002)