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Gene Review

dnt  -  dermonecrotic toxin

Bordetella bronchiseptica RB50

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Disease relevance of dnt


High impact information on dnt

  • Moreover, CNF1 and DNT stimulated DNA synthesis without activation of p42(mapk) and p44(mapk) providing additional evidence for a novel p21(rho)-dependent signaling pathway that leads to entry into the S phase of the cell cycle in Swiss 3T3 [4].
  • The purpose of these experiments was to clarify the role of this toxin in respiratory disease by comparing the pathogenicity in swine of two isogenic dnt mutants to their virulent DNT(+) parent strains [1].
  • Therefore, production of DNT by B. bronchiseptica is necessary to produce the lesions of turbinate atrophy and bronchopneumonia in pigs infected with this organism [1].
  • In this study, to analyze the functional and structural organization of DNT, we prepared 10 clones of hybridoma producing anti-DNT monoclonal antibodies [5].
  • Bordetella dermonecrotic toxin (DNT) stimulates the assembly of actin stress fibers and focal adhesions by deamidating or polyaminating Gln63 of the small GTPase Rho [5].

Chemical compound and disease context of dnt


Biological context of dnt


Anatomical context of dnt


Associations of dnt with chemical compounds


Other interactions of dnt

  • The fact that the most virulent isolate did not express dermonecrotic toxin suggests that this toxin does not play an important role in the virulence of the bacteria in the murine model [14].

Analytical, diagnostic and therapeutic context of dnt


  1. Role of the dermonecrotic toxin of Bordetella bronchiseptica in the pathogenesis of respiratory disease in swine. Brockmeier, S.L., Register, K.B., Magyar, T., Lax, A.J., Pullinger, G.D., Kunkle, R.A. Infect. Immun. (2002) [Pubmed]
  2. Stimulation of bone resorption by inflamed nasal mucosa, dermonecrotic toxin-containing conditioned medium from Pasteurella multocida, and purified dermonecrotic toxin from P. multocida. Kimman, T.G., Löwik, C.W., van de Wee-Pals, L.J., Thesingh, C.W., Defize, P., Kamp, E.M., Bijvoet, O.L. Infect. Immun. (1987) [Pubmed]
  3. Cloning, expression, and molecular characterization of the dermonecrotic toxin gene of Bordetella spp. Pullinger, G.D., Adams, T.E., Mullan, P.B., Garrod, T.I., Lax, A.J. Infect. Immun. (1996) [Pubmed]
  4. Cytotoxic necrotizing factor 1 from Escherichia coli and dermonecrotic toxin from Bordetella bronchiseptica induce p21(rho)-dependent tyrosine phosphorylation of focal adhesion kinase and paxillin in Swiss 3T3 cells. Lacerda, H.M., Pullinger, G.D., Lax, A.J., Rozengurt, E. J. Biol. Chem. (1997) [Pubmed]
  5. Identification of a receptor-binding domain of Bordetella dermonecrotic toxin. Matsuzawa, T., Kashimoto, T., Katahira, J., Horiguchi, Y. Infect. Immun. (2002) [Pubmed]
  6. Bordetella bronchiseptica dermonecrotizing toxin suppresses in vivo antibody responses in mice. Horiguchi, Y., Matsuda, H., Koyama, H., Nakai, T., Kume, K. FEMS Microbiol. Lett. (1992) [Pubmed]
  7. Characterization of dermonecrotic toxin produced by serotype D strains of Pasteurella multocida. Nakai, T., Sawata, A., Tsuji, M., Kume, K. Am. J. Vet. Res. (1984) [Pubmed]
  8. Clinical and pathological effects of the dermonecrotic toxin of Bordetella bronchiseptica and Pasteurella multocida in specific-pathogen-free piglets. Eliás, B., Boros, G., Albert, M., Tuboly, S., Gergely, P., Papp, L., Barna Vetró, I., Rafai, P., Molnár, E. Nippon Juigaku Zasshi (1990) [Pubmed]
  9. The pathological effect of the Bordetella dermonecrotic toxin in mice. Magyar, T., Glávits, R., Pullinger, G.D., Lax, A.J. Acta Vet. Hung. (2000) [Pubmed]
  10. Adherence of Pasteurella multocida or Bordetella bronchiseptica to the swine nasal epithelial cell in vitro. Nakai, T., Kume, K., Yoshikawa, H., Oyamada, T., Yoshikawa, T. Infect. Immun. (1988) [Pubmed]
  11. Bordetella avium virulence measured in vivo and in vitro. Temple, L.M., Weiss, A.A., Walker, K.E., Barnes, H.J., Christensen, V.L., Miyamoto, D.M., Shelton, C.B., Orndorff, P.E. Infect. Immun. (1998) [Pubmed]
  12. Effects of Bordetella bronchiseptica dermonecrotic toxin on the structure and function of osteoblastic clone MC3T3-e1 cells. Horiguchi, Y., Nakai, T., Kume, K. Infect. Immun. (1991) [Pubmed]
  13. Postantibiotic and physiological effects of tilmicosin, tylosin, and apramycin at subminimal and suprainhibitory concentrations on some swine and bovine respiratory tract pathogens. Diarra, M.S., Malouin, F., Jacques, M. Int. J. Antimicrob. Agents (1999) [Pubmed]
  14. Virulence of Bordetella bronchiseptica: role of adenylate cyclase-hemolysin. Gueirard, P., Guiso, N. Infect. Immun. (1993) [Pubmed]
  15. Purification and characterization of Bordetella bronchiseptica dermonecrotic toxin. Horiguchi, Y., Nakai, T., Kume, K. Microb. Pathog. (1989) [Pubmed]
  16. Induction of nasal turbinate atrophy in germ-free pigs, using Pasteurella multocida as well as bacterium-free crude and purified dermonecrotic toxin of P multocida. Kamp, E.M., Kimman, T.G. Am. J. Vet. Res. (1988) [Pubmed]
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