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Gene Review

PLCB3  -  phospholipase C, beta 3...

Homo sapiens

Synonyms: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3, PLC-beta-3, Phosphoinositide phospholipase C-beta-3, Phospholipase C-beta-3
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Disease relevance of PLCB3


High impact information on PLCB3

  • Based on the in vitro effects of PI-TP, we surmise that it is involved in transporting PI from intracellular compartments for conversion to PI bisphosphate (PIP2) prior to hydrolysis by PLC-beta 2/PLC-beta 3, the endogenous PLC isoforms present in these cells [5].
  • The best characterized of the intranuclear lipids are the inositol lipids that form the components of a phosphoinositide-phospholipase C cycle [6].
  • The increases in both motility and calpain activity by IP-9 were blocked by pharmacological and molecular inhibition of phospholipase C-beta3 and chelation of calcium, which prevented an intracellular calcium flux [7].
  • NHERF2 specifically interacts with LPA2 receptor and defines the specificity and efficiency of receptor-mediated phospholipase C-beta3 activation [8].
  • Consistently, LPA(2)-mediated PLC-beta activation was specifically inhibited by the gene silencing of PLC-beta3 [8].

Biological context of PLCB3


Anatomical context of PLCB3


Associations of PLCB3 with chemical compounds


Physical interactions of PLCB3


Regulatory relationships of PLCB3


Other interactions of PLCB3

  • We can now exclude PLCB3 from candidacy as the MEN1 gene [4].
  • Using its second PDZ domain, NHERF2 was found to indirectly link LPA(2) to PLC-beta3 to form a complex, and the other PLC-beta isozymes were not included in the protein complex [8].
  • Immunoprecipitation studies revealed that NHERF2 interacts specifically with PLC-beta3, but not with other PLC-beta isotypes [16].
  • Regulation of phospholipase C-beta 3 activity by Na+/H+ exchanger regulatory factor 2 [16].
  • Further assessment of homodimerization status by coimmunoprecipitation assays with differentially tagged PLC-beta3 fragments demonstrated that at least two subdomains of PLC-beta3 are involved in dimer formation, one in the catalytic X and Y domains and the other in the G protein-regulated carboxyl-terminal domain [20].

Analytical, diagnostic and therapeutic context of PLCB3


  1. Differentially expressed cDNAs in PLCbeta3-induced tumor suppression in a human endocrine pancreatic tumor cell line: activation of the human mismatch repair protein 3 gene. Stålberg, P., Lopez-Egido, J.R., Wang, S., Gobl, A., Oberg, K., Skogseid, B. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  2. In situ RNA-RNA hybridisation of phospholipase C beta 3 shows lack of expression in neuroendocrine tumours. Stålberg, P., Granberg, D., Carling, T., Wilander, E., Eriksson, B., Gobl, A., Akerström, G., Rastad, J., Modlin, I.M., Oberg, K., Skogseid, B. Anticancer Res. (2003) [Pubmed]
  3. Phospholipase C isoforms in vascular smooth muscle and their regulation by G-proteins. Blayney, L.M., Gapper, P.W., Newby, A.C. Br. J. Pharmacol. (1996) [Pubmed]
  4. Exclusion of the phosphoinositide-specific phospholipase C beta 3 (PLCB3) gene as a candidate for multiple endocrine neoplasia type 1. Weber, G., Grimmond, S., Lagercrantz, J., Friedman, E., Phelan, C., Carson, E., Hayward, N., Jacobovitz, O., Nordenskjöld, M., Larsson, C. Hum. Genet. (1997) [Pubmed]
  5. An essential role for phosphatidylinositol transfer protein in phospholipase C-mediated inositol lipid signaling. Thomas, G.M., Cunningham, E., Fensome, A., Ball, A., Totty, N.F., Truong, O., Hsuan, J.J., Cockcroft, S. Cell (1993) [Pubmed]
  6. Nuclear lipid signalling. Irvine, R.F. Nat. Rev. Mol. Cell Biol. (2003) [Pubmed]
  7. Interferon-inducible protein 9 (CXCL11)-induced cell motility in keratinocytes requires calcium flux-dependent activation of mu-calpain. Satish, L., Blair, H.C., Glading, A., Wells, A. Mol. Cell. Biol. (2005) [Pubmed]
  8. NHERF2 specifically interacts with LPA2 receptor and defines the specificity and efficiency of receptor-mediated phospholipase C-beta3 activation. Oh, Y.S., Jo, N.W., Choi, J.W., Kim, H.S., Seo, S.W., Kang, K.O., Hwang, J.I., Heo, K., Kim, S.H., Kim, Y.H., Kim, I.H., Kim, J.H., Banno, Y., Ryu, S.H., Suh, P.G. Mol. Cell. Biol. (2004) [Pubmed]
  9. Localization of the human phosphatidylinositol-specific phospholipase c beta 3 gene (PLCB3) within chromosome band 11q13. Sinke, R.J., Geurts van Kessel, A.G. Genomics (1995) [Pubmed]
  10. Identification and characterization of G protein-regulated phospholipase C in human myocardium. Schnabel, P., Gäs, H., Nohr, T., Camps, M., Böhm, M. J. Mol. Cell. Cardiol. (1996) [Pubmed]
  11. Hyperparathyroidism of multiple endocrine neoplasia type 1: candidate gene and parathyroid calcium sensing protein expression. Carling, T., Rastad, J., Ridefelt, P., Gobl, A., Hellman, P., Oberg, K., Rask, L., Larsson, C., Juhlin, C., Akerström, G. Surgery (1995) [Pubmed]
  12. Pertussis toxin-sensitive activation of phospholipase C by the C5a and fMet-Leu-Phe receptors. Jiang, H., Kuang, Y., Wu, Y., Smrcka, A., Simon, M.I., Wu, D. J. Biol. Chem. (1996) [Pubmed]
  13. Genomic organization and complete cDNA sequence of the human phosphoinositide-specific phospholipase C beta 3 gene (PLCB3). Lagercrantz, J., Carson, E., Phelan, C., Grimmond, S., Rosén, A., Daré, E., Nordenskjöld, M., Hayward, N.K., Larsson, C., Weber, G. Genomics (1995) [Pubmed]
  14. Phosphorylation and regulation of G-protein-activated phospholipase C-beta 3 by cGMP-dependent protein kinases. Xia, C., Bao, Z., Yue, C., Sanborn, B.M., Liu, M. J. Biol. Chem. (2001) [Pubmed]
  15. Contribution of phospholipase C-beta3 phosphorylation to the rapid attenuation of opioid-activated phosphoinositide response. Strassheim, D., Law, P.Y., Loh, H.H. Mol. Pharmacol. (1998) [Pubmed]
  16. Regulation of phospholipase C-beta 3 activity by Na+/H+ exchanger regulatory factor 2. Hwang, J.I., Heo, K., Shin, K.J., Kim, E., Yun, C., Ryu, S.H., Shin, H.S., Suh, P.G. J. Biol. Chem. (2000) [Pubmed]
  17. Identification of a region at the N-terminus of phospholipase C-beta 3 that interacts with G protein beta gamma subunits. Barr, A.J., Ali, H., Haribabu, B., Snyderman, R., Smrcka, A.V. Biochemistry (2000) [Pubmed]
  18. P2Y2 purinergic and M3 muscarinic acetylcholine receptors activate different phospholipase C-beta isoforms that are uniquely susceptible to protein kinase C-dependent phosphorylation and inactivation. Strassheim, D., Williams, C.L. J. Biol. Chem. (2000) [Pubmed]
  19. Endogenous cleavage of phospholipase C-beta 3 by agonist-induced activation of calpain in human platelets. Banno, Y., Nakashima, S., Hachiya, T., Nozawa, Y. J. Biol. Chem. (1995) [Pubmed]
  20. Phospholipase C-beta3 and -beta1 form homodimers, but not heterodimers, through catalytic and carboxyl-terminal domains. Zhang, Y., Vogel, W.K., McCullar, J.S., Greenwood, J.A., Filtz, T.M. Mol. Pharmacol. (2006) [Pubmed]
  21. Molecular cloning and characterization of a cDNA encoding mouse phospholipase C-beta3. Wang, S., Zhou, Y., Lukinius, A., Oberg, K., Skogseid, B., Gobl, A. Biochim. Biophys. Acta (1998) [Pubmed]
  22. Corticotropin-releasing factor induces phosphorylation of phospholipase C-gamma at tyrosine residues via its receptor 2beta in human epidermoid A-431 cells. Kiang, J.G., Ding, X.Z., Gist, I.D., Jones, R.R., Tsokos, G.C. Eur. J. Pharmacol. (1998) [Pubmed]
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