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Gene Review

GNAQ  -  guanine nucleotide binding protein (G...

Homo sapiens

Synonyms: CMC1, G-ALPHA-q, GAQ, Guanine nucleotide-binding protein G(q) subunit alpha, Guanine nucleotide-binding protein alpha-q, ...
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Disease relevance of GNAQ


Psychiatry related information on GNAQ


High impact information on GNAQ

  • However, reconstitution was not observed with cells that overexpressed G alpha q or G alpha 11 [9].
  • Further evaluation revealed that GRP-R in these cells tonically stimulated G alpha q/11, resulting in increased phospholipase C activation [10].
  • These data indicate that G alpha s, G alpha q/11, and G alpha i3 associate with Golgi membranes independent of G beta subunits and have distinctive distributions within the Golgi stack [11].
  • METHODS: We used selective antibodies to quantitate the levels of the G protein alpha subunits that regulate adenylate cyclase activity (G alpha s and G alpha i2) and phosphoinositide turnover (G alpha q/11) [12].
  • There were no significant differences in the immunolabeling of G alpha i1/2, G alpha q/11, or pertussis toxin-catalyzed [32P]ADP ribosylation in either tissue in the untreated bipolar affective disorder group compared with controls [12].

Chemical compound and disease context of GNAQ


Biological context of GNAQ


Anatomical context of GNAQ


Associations of GNAQ with chemical compounds


Physical interactions of GNAQ

  • Several lines of evidence indicate that the oxytocin receptor is functionally coupled to GTP-binding proteins of the G alpha q/11 class which stimulate phospholipase C activity [22].

Regulatory relationships of GNAQ


Other interactions of GNAQ


Analytical, diagnostic and therapeutic context of GNAQ


  1. The G protein beta gamma subunit transduces the muscarinic receptor signal for Ca2+ release in Xenopus oocytes. Stehno-Bittel, L., Krapivinsky, G., Krapivinsky, L., Perez-Terzic, C., Clapham, D.E. J. Biol. Chem. (1995) [Pubmed]
  2. Signal transduction during cardiac hypertrophy: the role of G alpha q, PLC beta I, and PKC. Jalili, T., Takeishi, Y., Walsh, R.A. Cardiovasc. Res. (1999) [Pubmed]
  3. Genomic sequence analysis of a key residue (Arg183) in human G alpha q in invasive non-functional pituitary adenomas. Farrell, W.E., Talbot, J.A., Bicknell, E.J., Simpson, D., Clayton, R.N. Clin. Endocrinol. (Oxf) (1997) [Pubmed]
  4. Saccharin activates cation conductance via inositol 1,4,5-trisphosphate production in a subset of isolated rod taste cells in the frog. Okada, Y., Fujiyama, R., Miyamoto, T., Sato, T. Eur. J. Neurosci. (2001) [Pubmed]
  5. A functional polymorphism of the Galphaq (GNAQ) gene is associated with accelerated mortality in African-American heart failure. Liggett, S.B., Kelly, R.J., Parekh, R.R., Matkovich, S.J., Benner, B.J., Hahn, H.S., Syed, F.M., Galvez, A.S., Case, K.L., McGuire, N., Odley, A.M., Sparks, L., Kardia, S.L., Dorn, G.W. Hum. Mol. Genet. (2007) [Pubmed]
  6. Increased G alpha q/11 immunoreactivity in postmortem occipital cortex from patients with bipolar affective disorder. Mathews, R., Li, P.P., Young, L.T., Kish, S.J., Warsh, J.J. Biol. Psychiatry (1997) [Pubmed]
  7. Phosphoinositide hydrolysis, G alpha q, phospholipase C, and protein kinase C in post mortem human brain: effects of post mortem interval, subject age, and Alzheimer's disease. Greenwood, A.F., Powers, R.E., Jope, R.S. Neuroscience (1995) [Pubmed]
  8. Validity and reliability of activity measures in African-American girls for GEMS. Treuth, M.S., Sherwood, N.E., Butte, N.F., McClanahan, B., Obarzanek, E., Zhou, A., Ayers, C., Adolph, A., Jordan, J., Jacobs, D.R., Rochon, J. Medicine and science in sports and exercise. (2003) [Pubmed]
  9. G protein-coupled signal transduction pathways for interleukin-8. Wu, D., LaRosa, G.J., Simon, M.I. Science (1993) [Pubmed]
  10. Constitutive activation of the gastrin-releasing peptide receptor expressed by the nonmalignant human colon epithelial cell line NCM460. Ferris, H.A., Carroll, R.E., Rasenick, M.M., Benya, R.V. J. Clin. Invest. (1997) [Pubmed]
  11. Differential distribution of alpha subunits and beta gamma subunits of heterotrimeric G proteins on Golgi membranes of the exocrine pancreas. Denker, S.P., McCaffery, J.M., Palade, G.E., Insel, P.A., Farquhar, M.G. J. Cell Biol. (1996) [Pubmed]
  12. Guanine nucleotide-binding proteins in bipolar affective disorder. Effects of long-term lithium treatment. Manji, H.K., Chen, G., Shimon, H., Hsiao, J.K., Potter, W.Z., Belmaker, R.H. Arch. Gen. Psychiatry (1995) [Pubmed]
  13. Cloning of a molluscan G protein alpha subunit of the Gq class which is expressed differentially in identified neurons. Knol, J.C., Ramnatsingh, S., van Kesteren, E.R., van Minnen, J., Planta, R.J., van Heerikhuizen, H., Vreugdenhil, E. Eur. J. Biochem. (1995) [Pubmed]
  14. Specificity of G alpha q and G alpha 11 gene expression in platelets and erythrocytes. Expressions of cellular differentiation and species differences. Johnson, G.J., Leis, L.A., Dunlop, P.C. Biochem. J. (1996) [Pubmed]
  15. G beta gamma mediates the interplay between tubulin dimers and microtubules in the modulation of Gq signaling. Popova, J.S., Rasenick, M.M. J. Biol. Chem. (2003) [Pubmed]
  16. Activation of phospholipase C by alpha 1-adrenergic receptors is mediated by the alpha subunits of Gq family. Wu, D., Katz, A., Lee, C.H., Simon, M.I. J. Biol. Chem. (1992) [Pubmed]
  17. Activation of platelet-activating factor receptor-coupled G alpha q leads to stimulation of Src and focal adhesion kinase via two separate pathways in human umbilical vein endothelial cells. Deo, D.D., Bazan, N.G., Hunt, J.D. J. Biol. Chem. (2004) [Pubmed]
  18. Identification and expression of G-proteins in human myometrium: up-regulation of G alpha s in pregnancy. Europe-Finner, G.N., Phaneuf, S., Watson, S.P., López Bernal, A. Endocrinology (1993) [Pubmed]
  19. Expression of G proteins in human placentas from pregnancies complicated by gestational hypertension. Petit, A., Geoffroy, P., Bélisle, S. Life Sci. (1997) [Pubmed]
  20. Coupling of metabotropic glutamate receptors 2 and 4 to G alpha 15, G alpha 16, and chimeric G alpha q/i proteins: characterization of new antagonists. Gomeza, J., Mary, S., Brabet, I., Parmentier, M.L., Restituito, S., Bockaert, J., Pin, J.P. Mol. Pharmacol. (1996) [Pubmed]
  21. Expression of angiotensin II type-I receptor and phospholipase C-linked G alpha q/11 protein in the human placenta. Petit, A., Geoffroy, P., Bélisle, S. J. Soc. Gynecol. Investig. (1996) [Pubmed]
  22. Molecular mechanisms regulating the effects of oxytocin on myometrial intracellular calcium. Sanborn, B.M., Dodge, K., Monga, M., Qian, A., Wang, W., Yue, C. Adv. Exp. Med. Biol. (1998) [Pubmed]
  23. GNAZ in human fetal cochlea: expression, localization, and potential role in inner ear function. Magovcevic, I., Khetarpal, U., Bieber, F.R., Morton, C.C. Hear. Res. (1995) [Pubmed]
  24. G protein-coupled receptor Kinase 2/G alpha q/11 interaction. A novel surface on a regulator of G protein signaling homology domain for binding G alpha subunits. Sterne-Marr, R., Tesmer, J.J., Day, P.W., Stracquatanio, R.P., Cilente, J.A., O'Connor, K.E., Pronin, A.N., Benovic, J.L., Wedegaertner, P.B. J. Biol. Chem. (2003) [Pubmed]
  25. Characterization of the cloned HEL cell thromboxane A2 receptor: evidence that the affinity state can be altered by G alpha 13 and G alpha q. Allan, C.J., Higashiura, K., Martin, M., Morinelli, T.A., Kurtz, D.T., Geoffroy, O., Meier, G.P., Gettys, T.W., Halushka, P.V. J. Pharmacol. Exp. Ther. (1996) [Pubmed]
  26. Successful amplification of extremely GC-rich promoter regions using a novel 'slowdown PCR' technique. Bachmann, H.S., Siffert, W., Frey, U.H. Pharmacogenetics (2003) [Pubmed]
  27. Screening of candidate oncogenes in human thyrotroph tumors: absence of activating mutations of the G alpha q, G alpha 11, G alpha s, or thyrotropin-releasing hormone receptor genes. Dong, Q., Brucker-Davis, F., Weintraub, B.D., Smallridge, R.C., Carr, F.E., Battey, J., Spiegel, A.M., Shenker, A. J. Clin. Endocrinol. Metab. (1996) [Pubmed]
  28. Impaired signal transduction in neonatal platelets. Israels, S.J., Cheang, T., Roberston, C., McMillan-Ward, E.M., McNicol, A. Pediatr. Res. (1999) [Pubmed]
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