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Gene Review

RB1  -  retinoblastoma 1

Bos taurus

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Disease relevance of RB1

  • Interestingly, when compared to an antiserum produced against bovine 106-121 peptidic sequence (RB1), we found strikingly different ratios of the PrP res glycoforms, in both cattle with BSE and sheep with natural scrapie, but not in scrapie infected mice [1].
  • 3':5'-Cyclic-AMP phosphodiesterase (EC and the activating factor of cyclic nucleotide phosphodiesterase were detected in cultured human cell lines from patients with lymphoblastic leukemia and retinoblastoma and in the Brown-Pearce (rabbit) carcinoma [2].
  • Fifty-five retinoblastoma specimens were studied by a sensitive immunoperoxidase method to determine the intermediate filament types present in human retina and retinoblastoma [3].
  • Examination of the retinoblastoma protein expressions in these adenocarcinoma cell lines revealed a phosphorylated pattern that correlated inversely with the mucin synthesis status of these cell lines.(ABSTRACT TRUNCATED AT 250 WORDS)[4]
  • The results indicate that certain neoplastic cells of medulloblastoma are capable of expression of photoreceptor-specific proteins and, thus, may be closely related to tumor cells of retinoblastoma and pineocytomas previously shown to bind antisera against retinal S-antigen and opsin [5].

High impact information on RB1


Biological context of RB1


Anatomical context of RB1


Associations of RB1 with chemical compounds


Analytical, diagnostic and therapeutic context of RB1


  1. Molecular specificities of antibodies against ovine and murine recombinant prion proteins. Betemps, D., Baron, T. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  2. Cyclic nucleotide phosphodiesterase and protein activator in human cancer cell lines and Brown-Pearce carcinoma. Liu, Y.P., Wong, V.G., Chabner, B.A. J. Natl. Cancer Inst. (1977) [Pubmed]
  3. Intermediate filaments in the human retina and retinoblastoma. An immunohistochemical study of vimentin, glial fibrillary acidic protein, and neurofilaments. Kivelä, T., Tarkkanen, A., Virtanen, I. Invest. Ophthalmol. Vis. Sci. (1986) [Pubmed]
  4. Characterization of the mucin differentiation in human lung adenocarcinoma cell lines. Yang, P.C., Luh, K.T., Wu, R., Wu, C.W. Am. J. Respir. Cell Mol. Biol. (1992) [Pubmed]
  5. Immunocytochemical evidence of molecular photoreceptor markers in cerebellar medulloblastomas. Korf, H.W., Czerwionka, M., Reiner, J., Schachenmayr, W., Schalken, J.J., de Grip, W., Gery, I. Cancer (1987) [Pubmed]
  6. Cyclin A and the retinoblastoma gene product complex with a common transcription factor. Bandara, L.R., Adamczewski, J.P., Hunt, T., La Thangue, N.B. Nature (1991) [Pubmed]
  7. Complex formation of human papillomavirus E7 proteins with the retinoblastoma tumor suppressor gene product. Münger, K., Werness, B.A., Dyson, N., Phelps, W.C., Harlow, E., Howley, P.M. EMBO J. (1989) [Pubmed]
  8. Molecular mechanism of endothelial growth arrest by laminar shear stress. Lin, K., Hsu, P.P., Chen, B.P., Yuan, S., Usami, S., Shyy, J.Y., Li, Y.S., Chien, S. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  9. Role of the retinoblastoma pathway in senescence triggered by repression of the human papillomavirus E7 protein in cervical carcinoma cells. Psyrri, A., DeFilippis, R.A., Edwards, A.P., Yates, K.E., Manuelidis, L., DiMaio, D. Cancer Res. (2004) [Pubmed]
  10. Overexpression of FGF-2 modulates fiber cell differentiation and survival in the mouse lens. Stolen, C.M., Jackson, M.W., Griep, A.E. Development (1997) [Pubmed]
  11. Neuronal Cdc2-like kinase (Nclk) binds and phosphorylates the retinoblastoma protein. Lee, K.Y., Helbing, C.C., Choi, K.S., Johnston, R.N., Wang, J.H. J. Biol. Chem. (1997) [Pubmed]
  12. Cyclin-dependent kinase inhibitor p16INK4A inhibits phosphorylation of RNA polymerase II by general transcription factor TFIIH. Serizawa, H. J. Biol. Chem. (1998) [Pubmed]
  13. Phorbol ester inhibits the phosphorylation of the retinoblastoma protein without suppressing cyclin D-associated kinase in vascular smooth muscle cells. Sasaguri, T., Ishida, A., Kosaka, C., Nojima, H., Ogata, J. J. Biol. Chem. (1996) [Pubmed]
  14. Differentiated carcinomas develop as a consequence of the thyroid specific expression of a thyroglobulin-human papillomavirus type 16 E7 transgene. Ledent, C., Marcotte, A., Dumont, J.E., Vassart, G., Parmentier, M. Oncogene (1995) [Pubmed]
  15. Co-cultivation of retinoblastoma with fibroblasts, iris pigment epithelium, and retinal pigment epithelium in tissue culture. Weiner, M.J., Albert, D.M., Gallie, B.L., Craft, J.L. Invest. Ophthalmol. Vis. Sci. (1983) [Pubmed]
  16. Accumulation of N-3 polyunsaturated fatty acids cultured human Y79 retinoblastoma cells. Hyman, B.T., Spector, A.A. J. Neurochem. (1981) [Pubmed]
  17. Retinoid-binding proteins in retinoblastoma tumors. Fong, S.L., Balakier, H., Canton, M., Bridges, C.D., Gallie, B. Cancer Res. (1988) [Pubmed]
  18. Apigenin inhibits endothelial-cell proliferation in G(2)/M phase whereas it stimulates smooth-muscle cells by inhibiting P21 and P27 expression. Trochon, V., Blot, E., Cymbalista, F., Engelmann, C., Tang, R.P., Thomaïdis, A., Vasse, M., Soria, J., Lu, H., Soria, C. Int. J. Cancer (2000) [Pubmed]
  19. Inhibition of mitogenic signaling and induction of apoptosis in human bladder smooth muscle cells treated with doxazosin. Austin, P.F., Cook, B.L., Niederhoff, R.A., Manson, S.R., Coplen, D.E., Weintraub, S.J. J. Urol. (2004) [Pubmed]
  20. Porous implant exposure: incidence, management, and morbidity. Custer, P.L., Trinkaus, K.M. Ophthalmic plastic and reconstructive surgery (2007) [Pubmed]
  21. Comparative gene mapping of lactoperoxidase, retinoblastoma, and alpha-lactalbumin genes in cattle, sheep, and goats. Hayes, H.C., Popescu, P., Dutrillaux, B. Mamm. Genome (1993) [Pubmed]
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