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Gene Review

DMP1  -  dentin matrix acidic phosphoprotein 1

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Disease relevance of DMP1

  • In contrast, phosphorylated bovine DMP1 expressed in marrow stromal cells with an adenovirus vector containing 29.7 phosphates/mol was an effective inhibitor of HA formation and growth [1].

High impact information on DMP1


Biological context of DMP1


Anatomical context of DMP1


Associations of DMP1 with chemical compounds

  • Comparison of the human DMP1-coding sequence with that of the rat, mouse, and cow indicated that the predicted protein contains a conserved hydrophobic signal peptide sequence and an Arg-Gly-Asp cell attachment sequence [4].
  • In this study, the effects of guanidine extracts from demineralized bovine dentin matrix on rat mesenchymal cells were investigated by use of an agarose gel culture [8].
  • The caries detector, 1.0% acid red solution in propylene glycol, failed to stain EDTA-demineralized bovine dentin matrix, but stained the same matrix when treated by lactic acid in a concentration above 0.01 M [9].
  • Demineralized dentin matrix was incubated in a metastable calcium phosphate solution with or without silicate, fluoride, calcium, phosphate, magnesium or silver [10].

Analytical, diagnostic and therapeutic context of DMP1


  1. In vitro effects of dentin matrix protein-1 on hydroxyapatite formation provide insights into in vivo functions. Tartaix, P.H., Doulaverakis, M., George, A., Fisher, L.W., Butler, W.T., Qin, C., Salih, E., Tan, M., Fujimoto, Y., Spevak, L., Boskey, A.L. J. Biol. Chem. (2004) [Pubmed]
  2. Identification of the chondrogenic-inducing activity from bovine dentin (bCIA) as a low-molecular-mass amelogenin polypeptide. Nebgen, D.R., Inoue, H., Sabsay, B., Wei, K., Ho, C.S., Veis, A. J. Dent. Res. (1999) [Pubmed]
  3. Cloning and expression analysis of the bovine dentin matrix acidic phosphoprotein gene. Hirst, K.L., Ibaraki-O'Connor, K., Young, M.F., Dixon, M.J. J. Dent. Res. (1997) [Pubmed]
  4. Elucidation of the sequence and the genomic organization of the human dentin matrix acidic phosphoprotein 1 (DMP1) gene: exclusion of the locus from a causative role in the pathogenesis of dentinogenesis imperfecta type II. Hirst, K.L., Simmons, D., Feng, J., Aplin, H., Dixon, M.J., MacDougall, M. Genomics (1997) [Pubmed]
  5. Promotion of selective cell attachment by the RGD sequence in dentine matrix protein 1. Kulkarni, G.V., Chen, B., Malone, J.P., Narayanan, A.S., George, A. Arch. Oral Biol. (2000) [Pubmed]
  6. Extracellular matrix proteins of dentine. Butler, W.T., Ritchie, H.H., Bronckers, A.L. Ciba Found. Symp. (1997) [Pubmed]
  7. Mitogenic and dentin-inductive effects of crude bone morphogenetic protein from bone and dentin in primary adult pulp cell culture. Nakashima, M. Oral Surg. Oral Med. Oral Pathol. (1992) [Pubmed]
  8. Chondrocyte-like colony formation of mesenchymal cells by dentin extracts in agarose gel culture. Harada, K., Oida, S., Sasaki, S., Enomoto, S. J. Dent. Res. (1990) [Pubmed]
  9. Mechanism of differential staining in carious dentin. Kuboki, Y., Liu, C.F., Fusayama, T. J. Dent. Res. (1983) [Pubmed]
  10. In vitro study of remineralization of dentin: effects of ions on mineral induction by decalcified dentin matrix. Saito, T., Toyooka, H., Ito, S., Crenshaw, M.A. Caries Res. (2003) [Pubmed]
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