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Gene Review

Dmp1  -  dentin matrix acidic phosphoprotein 1

Rattus norvegicus

Synonyms: AG1, DMP-1, Dentin matrix acidic phosphoprotein 1, Dentin matrix protein 1
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Disease relevance of Dmp1


High impact information on Dmp1

  • Dentin matrix protein 1 (DMP1) is an acidic noncollagenous protein expressed during the initial stages of mineralized matrix formation in bone and dentin [2].
  • We envision that the proteolytic processing of DMP1 plays a crucial role during osteogenesis and dentinogenesis [3].
  • Extensive sequencing of tryptic peptides revealed that the 37K fragments originated from the NH2-terminal region, and the 57K fragments were from the COOH-terminal part of DMP1 [3].
  • Some of the genes expressed include the dentin matrix proteins 1, 2, and 3, which are extracellular matrix molecules responsible for the ultimate formation of mineralized dentin [4].
  • It is now known that DMP1 is not unique to dentin but is present in other mineralized tissues like long bone, calvaria, and ameloblasts [5].

Biological context of Dmp1


Anatomical context of Dmp1

  • These observations indicate that Dmp1 may serve unique biological functions in osteocyte and bone metabolism [6].
  • At embryonic day 15 (E15), type I collagen and osteocalcin mRNAs were expressed by the majority of newly-differentiated osteoblasts attached to unmineralized bone matrices, whereas Dmp1 mRNA expression was confined to only a few osteoblasts [6].
  • In contrast, osteoblasts continued to express type I collagen and osteocalcin in 90-day-old rats, but transiently expressed Dmp1 mRNA, which was seen in the minority of osteoblasts at 14 days of postnatal life [6].
  • Colocalization of dentin matrix protein 1 and dentin sialoprotein at late stages of rat molar development [9].
  • In 5-week- and 8-week-old rats, strong immunoreactions for DMP1 were widely distributed in odontoblasts and predentin [9].

Associations of Dmp1 with chemical compounds

  • We have now identified, by cDNA cloning, a new serine-rich acidic protein of the dentin matrix, AG1, with a composition intermediate between the bone acidic proteins and dentin phosphophoryns [8].
  • AG1 contains single RGD integrin binding and N-glycosylation sequences [8].
  • However, the level of DMP1 mRNA expression in root odontoblasts decreased near the coronal part and was absent in coronal odontoblasts [10].
  • These findings imply that type I collagen regulates mRNA level of Dmp-1 and OCN gene that are predominantly expressed in active odontoblasts [11].
  • Soluble proteins extracted from rat incisor dentin matrix during demineralization with EDTA, and not precipitable with 1.0 M CaCl2, were active in the in vitro system [12].

Other interactions of Dmp1


Analytical, diagnostic and therapeutic context of Dmp1


  1. Effects of a high sucrose diet and intragastric sucrose feeding on the dentinogenesis, dental caries, and mineral excretion of the young rat. Pekkala, E., Hietala, E.L., Puukka, M., Larmas, M. Acta Odontol. Scand. (2000) [Pubmed]
  2. Dentin matrix protein 1 immobilized on type I collagen fibrils facilitates apatite deposition in vitro. He, G., George, A. J. Biol. Chem. (2004) [Pubmed]
  3. Evidence for the proteolytic processing of dentin matrix protein 1. Identification and characterization of processed fragments and cleavage sites. Qin, C., Brunn, J.C., Cook, R.G., Orkiszewski, R.S., Malone, J.P., Veis, A., Butler, W.T. J. Biol. Chem. (2003) [Pubmed]
  4. Odontoblast cells immortalized by telomerase produce mineralized dentin-like tissue both in vitro and in vivo. Hao, J., Narayanan, K., Ramachandran, A., He, G., Almushayt, A., Evans, C., George, A. J. Biol. Chem. (2002) [Pubmed]
  5. Cloning and characterization of rat dentin matrix protein 1 (DMP1) gene and its 5'-upstream region. Thotakura, S.R., Karthikeyan, N., Smith, T., Liu, K., George, A. J. Biol. Chem. (2000) [Pubmed]
  6. Differential expression of dentin matrix protein 1, type I collagen and osteocalcin genes in rat developing mandibular bone. Kamiya, N., Takagi, M. Histochem. J. (2001) [Pubmed]
  7. Establishment and characterization of a culture system for enzymatically released rat dental pulp cells. Yokose, S., Kadokura, H., Tajima, Y., Fujieda, K., Katayama, I., Matsuoka, T., Katayama, T. Calcif. Tissue Int. (2000) [Pubmed]
  8. Characterization of a novel dentin matrix acidic phosphoprotein. Implications for induction of biomineralization. George, A., Sabsay, B., Simonian, P.A., Veis, A. J. Biol. Chem. (1993) [Pubmed]
  9. Colocalization of dentin matrix protein 1 and dentin sialoprotein at late stages of rat molar development. Baba, O., Qin, C., Brunn, J.C., Wygant, J.N., McIntyre, B.W., Butler, W.T. Matrix Biol. (2004) [Pubmed]
  10. mRNA expression and protein localization of dentin matrix protein 1 during dental root formation. Toyosawa, S., Okabayashi, K., Komori, T., Ijuhin, N. Bone (2004) [Pubmed]
  11. Type I collagen regulated dentin matrix protein-1 (Dmp-1) and osteocalcin (OCN) gene expression of rat dental pulp cells. Mizuno, M., Miyamoto, T., Wada, K., Watatani, S., Zhang, G.X. J. Cell. Biochem. (2003) [Pubmed]
  12. The isolation and partial characterization of a rat incisor dentin matrix polypeptide with in vitro chondrogenic activity. Amar, S., Sires, B., Sabsay, B., Clohisy, J., Veis, A. J. Biol. Chem. (1991) [Pubmed]
  13. Sequential expression of matrix protein genes in developing rat teeth. Bleicher, F., Couble, M.L., Farges, J.C., Couble, P., Magloire, H. Matrix Biol. (1999) [Pubmed]
  14. Distribution of protein kinase C alpha and accumulation of extracellular Ca2+ during early dentin and enamel formation. Bawden, J.W., Rozell, B., Wurtz, T., Fouda, N., Hammarström, L. J. Dent. Res. (1994) [Pubmed]
  15. Expression of amelogenin mRNA sequences during development of rat molars. Wurtz, T., Lundmark, C., Christersson, C., Bawden, J.W., Slaby, I., Hammarström, L. J. Bone Miner. Res. (1996) [Pubmed]
  16. Noncollagenous proteins of a rat dentin matrix possessing bone morphogenetic activity. Butler, W.T., Mikulski, A., Urist, M.R., Bridges, G., Uyeno, S. J. Dent. Res. (1977) [Pubmed]
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