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IL18  -  interleukin 18

Bos taurus

 
 
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Disease relevance of IL18

 

High impact information on IL18

  • Compared with BASMC, CVC had lower mRNA expression for osteopontin, which promotes osteoclast attachment, but greater mRNA expression for the soluble inhibitory cytokine, IL-18 [5].
  • Interleukin-18 (IL-18) is a pleiotropic cytokine and plays important role in both the development of a functional immune system as well as the response of the organism to infection [1].
  • NK cells responded to exogenous IL-12 and IL-18 with the production of IFN-gamma [6].
  • In the present study, we addressed this hypothesis by investigating the intracellular localization of IL-18 and its receptor in bovine anterior pituitary gland [7].
  • Furthermore, the expression of GH mRNA in IL-18 immunoreactive cells was confirmed by immuno-laser microdissection [7].
 

Biological context of IL18

 

Anatomical context of IL18

  • IL-18 transcripts were weakly detected in B lymphocytes but inducible in the B cell line BL-3 [8].
  • Antigen-specific T cell lines demonstrated IL-18-dependent enhancement of IFN-gamma production, indicating that bovine T cells are one of the leukocyte subsets that respond to IL-18 [8].
  • In the small intestinal epithelium, CD4+ and CD8+ cells were markedly increased, and, simultaneously, enhanced production of interleukin-18 (IL-18) was confirmed in the intestinal epithelial cells [2].
  • The IL-18 mRNA was constitutively detected in goat alveolar macrophages with or without LPS, While, enhanced expression was detected in splenocytes and liver cells if treated by LPS, and can be weakly detected in Peripheral blood mononuclear cells (PBMCs) treated by activators [9].
  • In this study, we examined the concentration of bovine IL-18 in the sera of pregnant cows, their fetuses and newborn calves, and in colostrum in order to examine the role of IL-18 in bovine pregnancy and the neonatal period [10].
 

Associations of IL18 with chemical compounds

  • In this paper we report the isolation, cloning sequencing and expression of caprine precursor IL-18 [4].
 

Other interactions of IL18

  • Expression of proinflammatory (IL-1beta, IL-18, and tumor necrosis factor [TNF]alpha) and anti-inflammatory (IL-10, IL-IRa, and IL-4) cytokines was also assessed [11].
  • Subsequently, the distribution of the IL-18 receptor alpha (IL-18Ralpha) was investigated in order to understand IL-18 signaling among the anterior pituitary cells [7].
 

Analytical, diagnostic and therapeutic context of IL18

References

  1. Immune enhancing effects of recombinant bovine IL-18 on foot-and-mouth disease vaccination in mice model. Shi, X.J., Wang, B., Wang, M. Vaccine (2007) [Pubmed]
  2. Orally administered lactoferrin exerts an antimetastatic effect and enhances production of IL-18 in the intestinal epithelium. Kuhara, T., Iigo, M., Itoh, T., Ushida, Y., Sekine, K., Terada, N., Okamura, H., Tsuda, H. Nutrition and cancer. (2000) [Pubmed]
  3. Inflammatory cytokine gene expression in different types of granulomatous lesions during asymptomatic stages of bovine paratuberculosis. Tanaka, S., Sato, M., Onitsuka, T., Kamata, H., Yokomizo, Y. Vet. Pathol. (2005) [Pubmed]
  4. Molecular characterization and expression of caprine (Capra hircus) interleukin-18 cDNA. Hosamani, M., Mondal, B., Muneta, Y., Rasool, T.J. International journal of immunogenetics. (2005) [Pubmed]
  5. Regulation of RANKL-induced osteoclastic differentiation by vascular cells. Tintut, Y., Abedin, M., Cho, J., Choe, A., Lim, J., Demer, L.L. J. Mol. Cell. Cardiol. (2005) [Pubmed]
  6. Bovine splenic NK cells synthesize IFN-gamma in response to IL-12-containing supernatants from Babesia bovis-exposed monocyte cultures. Goff, W.L., Storset, A.K., Johnson, W.C., Brown, W.C. Parasite Immunol. (2006) [Pubmed]
  7. Localization of interleukin-18 and its receptor in somatotrophs of the bovine anterior pituitary gland. Nagai, Y., Nochi, T., Watanabe, K., Watanabe, K., Aso, H., Kitazawa, H., Matsuzaki, M., Ohwada, S., Yamaguchi, T. Cell Tissue Res. (2005) [Pubmed]
  8. Cloning of a cDNA encoding bovine interleukin-18 and analysis of IL-18 expression in macrophages and its IFN-gamma-inducing activity. Shoda, L.K., Zarlenga, D.S., Hirano, A., Brown, W.C. J. Interferon Cytokine Res. (1999) [Pubmed]
  9. Cloning and expression of goat interleukin-18 gene. Liu, W.Q., Zhao, H.K., Gao, Y.D., Zhong, J.F. J. Vet. Med. Sci. (2005) [Pubmed]
  10. Bovine IL-18 ELISA: detection of IL-18 in sera of pregnant cow and newborn calf, and in colostrum. Muneta, Y., Yoshihara, K., Minagawa, Y., Nagata, R., Yasuyuki, M., Yamaguchi, T., Takehara, K. Journal of immunoassay & immunochemistry. (2005) [Pubmed]
  11. Morphologic and molecular characterization of Salmonella typhimurium infection in neonatal calves. Santos, R.L., Zhang, S., Tsolis, R.M., Bäumler, A.J., Adams, L.G. Vet. Pathol. (2002) [Pubmed]
 
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