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Mill1  -  MHC I like leukocyte 1

Rattus norvegicus

 
 
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Disease relevance of Mill1

 

High impact information on Mill1

  • Rats have two Mill genes orthologous to mouse Mill1 and Mill2 near the leukocyte receptor complex, with expression patterns similar to those of their mouse counterparts [3].
  • Comparative genomics of the Mill family: a rapidly evolving MHC class I gene family [3].
  • A computer search of the database identified a horse Mill-like expressed sequence tag, indicating that Mill emerged before the radiation of mammals [3].
  • Changes in locomotor and stereotypic activities induced by an i.p. injection of either (+)-5-methyl-10,11-dihydro-5H-dibenzo(a,d)-cycloheptan-5,10-imine maleate (dizocilpine or MK-801; 0.3 mg/kg) or D-amphetamine sulfate (AMPH; 1.5 mg/kg) were studied in male Mill Hill hooded rats of different age [4].
  • Jujuboside A (JuA) is a glycoside extracted from the seed of Ziziphus jujuba Mill var. spinosa (Bunge) Hu ex H F Chou, a Chinese herbal medicine, which has long been known as a sedative-hypnotic drug [5].
 

Biological context of Mill1

  • Interspecies sequence comparison indicates that Mill is one of the most rapidly evolving class I gene families and that non-synonymous substitutions occur more frequently than synonymous substitutions in its alpha 1 domain, implicating the involvement of Mill in immune defenses [3].
  • The mutation, inherited as an autosomal recessive, arose spontaneously in a breeding colony of Lewis rats at the Medical Research Council Cellular Immunology Unit, Sir William Dunn School of Pathology, Oxford, U.K., in 1985 and the strain has now been established both in Oxford and at Mill Hill [6].
  • A steroidal glycoside from Polygonatum odoratum (Mill.) Druce. improves insulin resistance but does not alter insulin secretion in 90% pancreatectomized rats [7].
  • Groups of 50 rats were exposed by nose-only inhalation to aerosols of either the Mill A or the Mill D yellowcake [8].
 

Anatomical context of Mill1

  • Bioactive saponins and glycosides. X. On the constituents of zizyphi spinosi semen, the seeds of Zizyphus jujuba Mill. var. spinosa Hu (1): structures and histamine release-inhibitory effect of jujubosides A1 and C and acetyljujuboside B [9].
  • Effect of Foeniculum vulgare Mill. seed extract on the genital organs of male and female rats [10].
  • When bradykinin-induced contraction of the isolated rat ileum was tested in the presence of Aloe barbadensis Mill [11].
  • Influence of extremely low frequency electromagnetic field (ELF-EMF) on thyroid gland mast cells was investigated on male Mill Hill rats [12].
  • An ethanolic extract of Parsley, Petroselinum crispum (Mill.) Nym.ex A.W. Hill (Umbelliferae), was tested for its ability to inhibit gastric secretion and to protect gastric mucosa against the injuries caused by pyloric ligation, hypothermic restraint stress, indomethacin and cytodestructive agents (80% ethanol, 0.2 M NaOH and 25% NaCl) in rats [13].
 

Associations of Mill1 with chemical compounds

  • Biological tests were also performed on the major pure components of L. angustifolia Mill. essential oil: linalol and linalyl acetate as determined by GC and confirmed by GC-MS [14].
  • The juice of whole fruits of Sicilian cultivars of prickly pear (Opuntia ficus indica (L.) Mill.) was investigated, and the contents of ascorbic acid, total polyphenols, and flavonoids were determined [15].
  • For the Mill D yellowcake, 25% initial lung burden cleared with T 1/2 of 3.5 days and 75% with T 1/2 of 110 days [8].
  • In vitro dissolution studies indicated for the Mill A sample, approximately 85% of the uranium had a dissolution half-time (T 1/2) of less than one day, with the remainder dissolving with a half-time of 500 days [8].
  • Opuntia ficus indica (L.) Mill. fruit juice protects liver from carbon tetrachloride-induced injury [16].
 

Analytical, diagnostic and therapeutic context of Mill1

  • Jujuboside A (JuA) is a main component of jujubogenin extracted from the seed of Ziziphus jujuba Mill var spinosa (Bunge) Hu ex H F Chou (Ziziphus), which is widely used in Chinese traditional medicine for the treatment of insomnia and anxiety [17].

References

  1. Pharmacological studies on a plant lectin aloctin A. II. Inhibitory effect of aloctin A on experimental models of inflammation in rats. Saito, H., Ishiguro, T., Imanishi, K., Suzuki, I. Jpn. J. Pharmacol. (1982) [Pubmed]
  2. Antiulcer activity of Opuntia ficus indica (L.) Mill. (Cactaceae): ultrastructural study. Galati, E.M., Monforte, M.T., Tripodo, M.M., d'Aquino, A., Mondello, M.R. Journal of ethnopharmacology. (2001) [Pubmed]
  3. Comparative genomics of the Mill family: a rapidly evolving MHC class I gene family. Watanabe, Y., Maruoka, T., Walter, L., Kasahara, M. Eur. J. Immunol. (2004) [Pubmed]
  4. Age-related differences in MK-801- and amphetamine-induced locomotor and stereotypic activities of rats. Vasilev, V., Veskov, R., Janać, B., Rakić, L.j., Stojiljković, M. Neurobiol. Aging (2003) [Pubmed]
  5. The inhibitory effects of jujuboside A on rat hippocampus in vivo and in vitro. Shou, C., Feng, Z., Wang, J., Zheng, X. Planta Med. (2002) [Pubmed]
  6. Growth hormone-deficient dwarfism in the rat: a new mutation. Charlton, H.M., Clark, R.G., Robinson, I.C., Goff, A.E., Cox, B.S., Bugnon, C., Bloch, B.A. J. Endocrinol. (1988) [Pubmed]
  7. A steroidal glycoside from Polygonatum odoratum (Mill.) Druce. improves insulin resistance but does not alter insulin secretion in 90% pancreatectomized rats. Choi, S.B., Park, S. Biosci. Biotechnol. Biochem. (2002) [Pubmed]
  8. Comparison of early lung clearance of yellowcake aerosols in rats with in vitro dissolution and IR analysis. Damon, E.G., Eidson, A.F., Hahn, F.F., Griffith, W.C., Guilmette, R.A. Health physics. (1984) [Pubmed]
  9. Bioactive saponins and glycosides. X. On the constituents of zizyphi spinosi semen, the seeds of Zizyphus jujuba Mill. var. spinosa Hu (1): structures and histamine release-inhibitory effect of jujubosides A1 and C and acetyljujuboside B. Yoshikawa, M., Murakami, T., Ikebata, A., Wakao, S., Murakami, N., Matsuda, H., Yamahara, J. Chem. Pharm. Bull. (1997) [Pubmed]
  10. Effect of Foeniculum vulgare Mill. seed extract on the genital organs of male and female rats. Malini, T., Vanithakumari, G., Megala, N., Anusya, S., Devi, K., Elango, V. Indian J. Physiol. Pharmacol. (1985) [Pubmed]
  11. In vitro antibradykinin activity of Aloe barbadensis gel. Bautista-Pérez, R., Segura-Cobos, D., Vázquez-Cruz, B. Journal of ethnopharmacology. (2004) [Pubmed]
  12. Stereological analysis of thyroid mast cells in rats after exposure to extremely low frequency electromagnetic field and the following "off" field period. Rajkovic, V., Matavulj, M., Lazetic, B. Acta. Biol. Hung. (2005) [Pubmed]
  13. Prevention of experimentally-induced gastric ulcers in rats by an ethanolic extract of "Parsley" Petroselinum crispum. Al-Howiriny, T., Al-Sohaibani, M., El-Tahir, K., Rafatullah, S. Am. J. Chin. Med. (2003) [Pubmed]
  14. Local anaesthetic activity of the essential oil of Lavandula angustifolia. Ghelardini, C., Galeotti, N., Salvatore, G., Mazzanti, G. Planta Med. (1999) [Pubmed]
  15. Chemical characterization and biological effects of Sicilian Opuntia ficus indica (L.) mill. Fruit juice: antioxidant and antiulcerogenic activity. Galati, E.M., Mondello, M.R., Giuffrida, D., Dugo, G., Miceli, N., Pergolizzi, S., Taviano, M.F. J. Agric. Food Chem. (2003) [Pubmed]
  16. Opuntia ficus indica (L.) Mill. fruit juice protects liver from carbon tetrachloride-induced injury. Galati, E.M., Mondello, M.R., Lauriano, E.R., Taviano, M.F., Galluzzo, M., Miceli, N. Phytotherapy research : PTR. (2005) [Pubmed]
  17. Inhibitory effect of jujuboside A on glutamate-mediated excitatory signal pathway in hippocampus. Zhang, M., Ning, G., Shou, C., Lu, Y., Hong, D., Zheng, X. Planta Med. (2003) [Pubmed]
 
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