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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Ficus


High impact information on Ficus

  • 1. Fully active ficin (EC containing 1 mol of thiol with high reactivity towards 2,2'-dipyridyl disulphide (2-Py-S-S-2-Py) at pH4.5 per mol of protein was prepared from the dried latex of Ficus glabrata by covalent chromatography on a Sepharose-glutathione-2-pyridyl disulphide gel [5].
  • BACKGROUND: Ornamental Ficus benjamina (FB) has been recognized as a new indoor allergen [1].
  • A new anti-inflammatory glucoside from Ficus racemosa L [6].
  • Bioassay-guided fractionation of the ethanol extract of Ficus racemosa resulted in the identification of a new compound (rel)-4,6-dihydroxy-5-[3-methyl-(E)-propenoic acid-3-yl]-7-beta-glucopyranosyl-[2alpha,3beta-dihydrobenzofuran]-(3,2: b)-[4alpha,5beta-dihydroxy-6alpha-hydroxymethyltetrahydropyran] (racemosic acid) [6].
  • Purification and characterization of an antifungal chitinase in jelly fig (Ficus awkeotsang) achenes [7].

Chemical compound and disease context of Ficus

  • CONCLUSIONS: We reason that Ficus and Morus are closely related genera of the Moraceae family and speculate that hypersensitivity to figs and mulberries might be associated as the result of allergen cross-reactivity rather than mere coincidence [8].

Biological context of Ficus

  • In order to understand both the biogeographical history of the Ceratosolen species associated with Ficus of the subgenus Sycomorus and the origins of the specificity breakdown cases, we have used cytochrome b sequences to reconstruct a phylogeny of the fig wasps [9].
  • Pectinesterase Inhibitor from Jelly Fig (Ficus awkeotsang Makino) Achene Induces Apoptosis of Human Leukemic U937 Cells [10].
  • Modulatory effect of Ficus racemosa: diminution of potassium bromate-induced renal oxidative injury and cell proliferation response [11].
  • Parameters related to oxidative stress were studied in rats divided into 4 groups: streptozotocin-induced diabetic rats (n=10), diabetic rats who received a single dose of a basic fraction of Ficus carica extract (n=14), diabetic rats who received a single dose of a chloroform fraction of the extract (n=10), and normal rats (n=10) [12].

Anatomical context of Ficus

  • When O. ficus indica cladodes are administered as a preventive therapy, keep the gastric mucosa under normal condition by preventing mucus dissolution caused by ethanol and favouring mucus production [13].
  • Isoproteinous diets containing 1% cholesterol and 10% fibre derived from plant foods namely, peepalbanti (Ficus religiosa), barbanti (Ficus bengalensis), gullar (Ficus glomerata), teent (Capparis decidua) and khejri beans (Prsopsis cineria) or pure cellulose, were fed to rats for 40 days [14].

Associations of Ficus with chemical compounds

  • The allergen of Ficus benjamina in house dust [15].
  • The galactosyl lipid was prepared by chemical synthesis from D-galactose and ficaprenol extracted from Ficus elastica [16].
  • Pectinesterase inhibitor from jelly-fig (Ficus awkeotsang Makino) achenes reduces methanol content in carambola wine [17].
  • Partition (K) and permeance (P) coefficients have been determined for phenol, 2-nitrophenol, and 4-nitrophenol with isolated cuticles from mature tomato (Lycopersicon) and green pepper (Capsicum) fruits and from the adaxial surface of rubber (Ficus) leaves [18].
  • The juice of whole fruits of Sicilian cultivars of prickly pear (Opuntia ficus indica (L.) Mill.) was investigated, and the contents of ascorbic acid, total polyphenols, and flavonoids were determined [19].

Gene context of Ficus


Analytical, diagnostic and therapeutic context of Ficus


  1. Sensitization to Ficus benjamina: relationship to natural rubber latex allergy and identification of foods implicated in the Ficus-fruit syndrome. Hemmer, W., Focke, M., Götz, M., Jarisch, R. Clin. Exp. Allergy (2004) [Pubmed]
  2. Cross-reactivity between Ficus benjamina latex and fig fruit in patients with clinical fig allergy. Focke, M., Hemmer, W., Wöhrl, S., Götz, M., Jarisch, R. Clin. Exp. Allergy (2003) [Pubmed]
  3. Hypersensitivity to latex and Ficus benjamina allergens. Delbourg, M.F., Moneret-Vautrin, D.A., Guilloux, L., Ville, G. Ann. Allergy Asthma Immunol. (1995) [Pubmed]
  4. Urticaria and rhinitis to shrubs of Ficus benjamina and breadfruit in a banana-allergic road worker: evidence for a cross-sensitization between Moracea, banana and latex. De Greef, J.M., Lieutier-Colas, F., Bessot, J.C., Vérot, A., Gallerand, A.M., Pauli, G., de Blay, F. Int. Arch. Allergy Immunol. (2001) [Pubmed]
  5. Preparation of fully active ficin from Ficus glabrata by covalent chromatography and characterization of its active centre by using 2,2'-depyridyl disulphide as a reactivity probe. Malthouse, J.P., Brocklehurst, K. Biochem. J. (1976) [Pubmed]
  6. A new anti-inflammatory glucoside from Ficus racemosa L. Li, R.W., Leach, D.N., Myers, S.P., Lin, G.D., Leach, G.J., Waterman, P.G. Planta Med. (2004) [Pubmed]
  7. Purification and characterization of an antifungal chitinase in jelly fig (Ficus awkeotsang) achenes. Li, Y.C., Chang, C.T., Hsiao, E.S., Hsu, J.S., Huang, J.W., Tzen, J.T. Plant Cell Physiol. (2003) [Pubmed]
  8. Fig and mulberry cross-allergy. Caiaffa, M.F., Cataldo, V.M., Tursi, A., Macchia, L. Ann. Allergy Asthma Immunol. (2003) [Pubmed]
  9. Molecular phylogeny of the Ceratosolen species pollinating Ficus of the subgenus Sycomorus sensu stricto: biogeographical history and origins of the species-specificity breakdown cases. Kerdelhue, C., Le Clainche, I., Rasplus, J.Y. Mol. Phylogenet. Evol. (1999) [Pubmed]
  10. Pectinesterase Inhibitor from Jelly Fig (Ficus awkeotsang Makino) Achene Induces Apoptosis of Human Leukemic U937 Cells. Chang, J.H., Wang, Y.T., Chang, H.M. Ann. N. Y. Acad. Sci. (2005) [Pubmed]
  11. Modulatory effect of Ficus racemosa: diminution of potassium bromate-induced renal oxidative injury and cell proliferation response. Khan, N., Sultana, S. Basic & clinical pharmacology & toxicology. (2005) [Pubmed]
  12. Experimental diabetes treated with ficus carica extract: effect on oxidative stress parameters. Pèrez, C., Canal, J.R., Torres, M.D. Acta diabetologica. (2003) [Pubmed]
  13. Study on the increment of the production of gastric mucus in rats treated with Opuntia ficus indica (L.) Mill. cladodes. Galati, E.M., Pergolizzi, S., Miceli, N., Monforte, M.T., Tripodo, M.M. Journal of ethnopharmacology. (2002) [Pubmed]
  14. Effect of feeding some plant foods as source of dietary fibre on biological utilisation of diet in rats. Agarwal, V., Chauhan, B.M. Plant foods for human nutrition (Dordrecht, Netherlands) (1989) [Pubmed]
  15. The allergen of Ficus benjamina in house dust. Bircher, A.J., Langauer, S., Levy, F., Wahl, R. Clin. Exp. Allergy (1995) [Pubmed]
  16. Chemically synthesized galactosyl ficaprenyl diphosphate as an intermediate in the biosynthesis of the Salmonella O-antigenic polysaccharide. Kanegasaki, S., Wright, A., Warren, C.D. Eur. J. Biochem. (1983) [Pubmed]
  17. Pectinesterase inhibitor from jelly-fig (Ficus awkeotsang Makino) achenes reduces methanol content in carambola wine. Wu, J.S., Wu, M.C., Jiang, C.M., Hwang, Y.P., Shen, S.C., Chang, H.M. J. Agric. Food Chem. (2005) [Pubmed]
  18. Accumulation and transport of phenol, 2-nitrophenol, and 4-nitrophenol in plant cuticles. Shafer, W.E., Schönherr, J. Ecotoxicol. Environ. Saf. (1985) [Pubmed]
  19. Chemical characterization and biological effects of Sicilian Opuntia ficus indica (L.) mill. Fruit juice: antioxidant and antiulcerogenic activity. Galati, E.M., Mondello, M.R., Giuffrida, D., Dugo, G., Miceli, N., Pergolizzi, S., Taviano, M.F. J. Agric. Food Chem. (2003) [Pubmed]
  20. Activation and inactivation of human factor X by proteases derived from Ficus carica. Richter, G., Schwarz, H.P., Dorner, F., Turecek, P.L. Br. J. Haematol. (2002) [Pubmed]
  21. Cross-reactivity between Ficus benjamina (weeping fig) and natural rubber latex. Brehler, R., Abrams, E., Sedlmayr, S. Allergy (1998) [Pubmed]
  22. Asthma caused by Ficus benjamina latex: evidence of cross-reactivity with fig fruit and papain. Díez-Gómez, M.L., Quirce, S., Aragoneses, E., Cuevas, M. Ann. Allergy Asthma Immunol. (1998) [Pubmed]
  23. Modulation of cancer cell multidrug resistance by an extract of Ficus citrifolia. Simon, P.N., Chaboud, A., Darbour, N., Di Pietro, A., Dumontet, C., Lurel, F., Raynaud, J., Barron, D. Anticancer Res. (2001) [Pubmed]
  24. Antioxidant activities of sicilian prickly pear (Opuntia ficus indica) fruit extracts and reducing properties of its betalains: betanin and indicaxanthin. Butera, D., Tesoriere, L., Di Gaudio, F., Bongiorno, A., Allegra, M., Pintaudi, A.M., Kohen, R., Livrea, M.A. J. Agric. Food Chem. (2002) [Pubmed]
  25. The anti-inflammatory effect of a crude aqueous extract of the root bark of "Ficus elastica" in the rat. Sackeyfio, A.C., Lugeleka, O.M. Archives internationales de pharmacodynamie et de thérapie. (1986) [Pubmed]
  26. Characterization of allergenic components in sap extract from the weeping fig (Ficus benjamina). Axelsson, I.G., Johansson, S.G., Larsson, P.H., Zetterström, O. Int. Arch. Allergy Appl. Immunol. (1990) [Pubmed]
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