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Gene Review

DPP7  -  dipeptidyl-peptidase 7

Homo sapiens

Synonyms: DPP II, DPP2, DPPII, Dipeptidyl aminopeptidase II, Dipeptidyl peptidase 2, ...
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Disease relevance of DPP7


Psychiatry related information on DPP7


High impact information on DPP7


Chemical compound and disease context of DPP7

  • Serum glycyl-l-prolyl 4-methyl-coumaryl-7-amide (gly-pro-MCA) hydrolase (DPP IV) and L-lysyl-L-alanyl beta-naphthylamide (lys-ala-beta NA) hydrolase (assumed to be DPP II) activities were measured in patients with oral squamous cell carcinoma and healthy subjects [10].
  • In 115 patients with chronic lymphocytic leukemia (CLL), grouped according to the staging system as proposed by Rai et al., dipeptidylpeptidase II (DPP II) reaction was carried out in smears of peripheral blood using Lys-Pro-MNA and Lys-Ala-MNA as substrates and Fast Blue B (FBB) as the coupling agent in cacodylate buffer, pH 5 [11].

Biological context of DPP7


Anatomical context of DPP7


Associations of DPP7 with chemical compounds


Regulatory relationships of DPP7


Other interactions of DPP7


Analytical, diagnostic and therapeutic context of DPP7


  1. Dipeptidyl peptidase IV inhibition for the treatment of type 2 diabetes: potential importance of selectivity over dipeptidyl peptidases 8 and 9. Lankas, G.R., Leiting, B., Roy, R.S., Eiermann, G.J., Beconi, M.G., Biftu, T., Chan, C.C., Edmondson, S., Feeney, W.P., He, H., Ippolito, D.E., Kim, D., Lyons, K.A., Ok, H.O., Patel, R.A., Petrov, A.N., Pryor, K.A., Qian, X., Reigle, L., Woods, A., Wu, J.K., Zaller, D., Zhang, X., Zhu, L., Weber, A.E., Thornberry, N.A. Diabetes (2005) [Pubmed]
  2. Activities of dipeptidyl peptidase II and dipeptidyl peptidase IV in mice with lupus erythematosus-like syndrome and in patients with lupus erythematosus and rheumatoid arthritis. Hagihara, M., Ohhashi, M., Nagatsu, T. Clin. Chem. (1987) [Pubmed]
  3. Activities of dipeptidyl peptidase II and dipeptidyl peptidase IV in synovial fluid from patients with rheumatoid arthritis and osteoarthritis. Gotoh, H., Hagihara, M., Nagatsu, T., Iwata, H., Miura, T. Clin. Chem. (1989) [Pubmed]
  4. Activity of dipeptidyl peptidase II and dipeptidyl peptidase IV in human gingiva with chronic marginal periodontitis. Mizutani, T., Mizutani, H., Kaneda, T., Hagihara, M., Nagatsu, T. Arch. Oral Biol. (1990) [Pubmed]
  5. Correlation between gingival crevicular fluid dipeptidyl peptidase II and IV activity and periodontal attachment loss. A 2-year longitudinal study in chronic periodontitis patients. Eley, B.M., Cox, S.W. Oral diseases. (1995) [Pubmed]
  6. Comparison of cathepsin protease activities in brain tissue from normal cases and cases with Alzheimer's disease, Lewy body dementia, Parkinson's disease and Huntington's disease. Mantle, D., Falkous, G., Ishiura, S., Perry, R.H., Perry, E.K. J. Neurol. Sci. (1995) [Pubmed]
  7. Alteration in dipeptidyl peptidase activities in cultured human carcinoma cells. Komatsu, M., Urade, M., Yamaoka, M., Fukasawa, K., Harada, M. J. Natl. Cancer Inst. (1987) [Pubmed]
  8. Homodimerization via a leucine zipper motif is required for enzymatic activity of quiescent cell proline dipeptidase. Chiravuri, M., Lee, H., Mathieu, S.L., Huber, B.T. J. Biol. Chem. (2000) [Pubmed]
  9. Vesicular localization and characterization of a novel post-proline-cleaving aminodipeptidase, quiescent cell proline dipeptidase. Chiravuri, M., Agarraberes, F., Mathieu, S.L., Lee, H., Huber, B.T. J. Immunol. (2000) [Pubmed]
  10. Serum dipeptidyl peptidase activities as a possible marker of oral cancer. Urade, M., Komatsu, M., Yamaoka, M., Fukasawa, K., Harada, M., Mima, T., Matsuya, T. Cancer (1989) [Pubmed]
  11. Possible prognostic significance of the assessment of dipeptidylpeptidase II in peripheral blood lymphocytes of patients with chronic lymphocytic leukemia. Klener, P., Lojda, Z., Háber, J., Kvasnicka, J. Neoplasma (1987) [Pubmed]
  12. Boro-norleucine as a P1 residue for the design of selective and potent DPP7 inhibitors. Shreder, K.R., Wong, M.S., Corral, S., Yu, Z., Winn, D.T., Wu, M., Hu, Y., Nomanbhoy, T., Alemayehu, S., Fuller, S.R., Rosenblum, J.S., Kozarich, J.W. Bioorg. Med. Chem. Lett. (2005) [Pubmed]
  13. Synthesis and structure-activity relationship of N-alkyl Gly-boro-Pro inhibitors of DPP4, FAP, and DPP7. Hu, Y., Ma, L., Wu, M., Wong, M.S., Li, B., Corral, S., Yu, Z., Nomanbhoy, T., Alemayehu, S., Fuller, S.R., Rosenblum, J.S., Rozenkrants, N., Minimo, L.C., Ripka, W.C., Szardenings, A.K., Kozarich, J.W., Shreder, K.R. Bioorg. Med. Chem. Lett. (2005) [Pubmed]
  14. Sequence, purification, and cloning of an intracellular serine protease, quiescent cell proline dipeptidase. Underwood, R., Chiravuri, M., Lee, H., Schmitz, T., Kabcenell, A.K., Yardley, K., Huber, B.T. J. Biol. Chem. (1999) [Pubmed]
  15. Catalytic properties and inhibition of proline-specific dipeptidyl peptidases II, IV and VII. Leiting, B., Pryor, K.D., Wu, J.K., Marsilio, F., Patel, R.A., Craik, C.S., Ellman, J.A., Cummings, R.T., Thornberry, N.A. Biochem. J. (2003) [Pubmed]
  16. Aminodipeptidase inhibitor-induced cell death in quiescent lymphocytes: a review. Chiravuri, M., Huber, B.T. Apoptosis (2000) [Pubmed]
  17. Structure-activity relationships of boronic acid inhibitors of dipeptidyl peptidase IV. 1. Variation of the P2 position of Xaa-boroPro dipeptides. Coutts, S.J., Kelly, T.A., Snow, R.J., Kennedy, C.A., Barton, R.W., Adams, J., Krolikowski, D.A., Freeman, D.M., Campbell, S.J., Ksiazek, J.F., Bachovchin, W.W. J. Med. Chem. (1996) [Pubmed]
  18. Dipeptidyl peptidase IV of human lymphocytes. Evidence for specific hydrolysis of glycylproline p-nitroanilide in T-lymphocytes. Schön, E., Demuth, H.U., Barth, A., Ansorge, S. Biochem. J. (1984) [Pubmed]
  19. Glutamic acid analogues as potent dipeptidyl peptidase IV and 8 inhibitors. Lu, I.L., Lee, S.J., Tsu, H., Wu, S.Y., Kao, K.H., Chien, C.H., Chang, Y.Y., Chen, Y.S., Cheng, J.H., Chang, C.N., Chen, T.W., Chang, S.P., Chen, X., Jiaang, W.T. Bioorg. Med. Chem. Lett. (2005) [Pubmed]
  20. Study on dipeptidylpeptidase II (DPP II). Gossrau, R., Lojda, Z. Histochemistry (1980) [Pubmed]
  21. Inhibition of dipeptidyl-peptidase IV catalyzed peptide truncation by Vildagliptin ((2S)-{[(3-hydroxyadamantan-1-yl)amino]acetyl}-pyrrolidine-2-carbonitrile). Brandt, I., Joossens, J., Chen, X., Maes, M.B., Scharpé, S., De Meester, I., Lambeir, A.M. Biochem. Pharmacol. (2005) [Pubmed]
  22. Design of (omega-N-(O-acyl)hydroxy amid) aminodicarboxylic acid pyrrolidides as potent inhibitors of proline-specific peptidases. Demuth, H.U., Schlenzig, D., Schierhorn, A., Grosche, G., Chapot-Chartier, M.P., Gripon, J.C. FEBS Lett. (1993) [Pubmed]
  23. Lysosomal dipeptidyl-peptidases I and II in human squamous cell lung carcinoma and lung parenchyma. Krepela, E., Procházka, J., Mynaríková, H., Kárová, B., Cermák, J., Roubková, H. Neoplasma (1996) [Pubmed]
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