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Gene Review

DPPA3  -  developmental pluripotency associated 3

Homo sapiens

Synonyms: Developmental pluripotency-associated protein 3, STELLAR, Stella, Stella-related protein
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Disease relevance of DPPA3


Psychiatry related information on DPPA3

  • These findings suggest a similar role for STELLA during early human development as in mice and a potential involvement in germ cell tumors [5].
  • This study, together with the previously published VBM study (Brambati, S.M., Termine, C., Ruffino, M., Stella, G., Fazio, F., Cappa, S.F. and Perani, D., Regional reductions of gray matter volume in familial dyslexia, Neurology, 63 (2004) 742-5), provides a multiple modality evaluation of familial dyslexia [6].

High impact information on DPPA3


Biological context of DPPA3


Anatomical context of DPPA3

  • The expression patterns of mouse and human DPPA3, in undifferentiated embryonic cells, embryonic germ cells and adult germ cell tumours, together suggest a role for this gene in maintaining cell pluripotentiality [12].
  • Furthermore, we show that STELLA that is expressed in human oocytes is also expressed in human pluripotent cells and in germ cell tumors [5].
  • STELLA, a compartmental modeling software program, was used to develop a kinetic model that includes the blood pool, thyroid, gastrointestinal tract, kidneys, bladder, and a conventional dialysis machine [13].

Associations of DPPA3 with chemical compounds

  • An ocular pharmacokinetic simulation model was constructed for timolol with the Stella program using the absorption and desorption rate constants and previously published in vivo pharmacokinetic parameters [14].
  • Since the simulations were in good agreement with the experimental results, it is concluded that STELLA simulation programme is useful in predicting pilocarpine formation [15].
  • Rates for pilocarpine formation were both determined by experiment and calculated using the STELLA simulation programme with known degradation rate constants of pilocarpic acid diesters and monoesters [15].

Analytical, diagnostic and therapeutic context of DPPA3

  • To improve understanding of this process, the role of stomata in uptake of gas-phase polychlorinated biphenyls (PCBs) was investigated using Hemerocallis x hybrida "Black Eyed Stella", a plant with a high stomatal density [16].
  • Endometrial curettage showed a proliferative phase and suspicious fragment resembling Arias Stella reaction [17].


  1. Down-regulation of stem cell genes, including those in a 200-kb gene cluster at 12p13.31, is associated with in vivo differentiation of human male germ cell tumors. Korkola, J.E., Houldsworth, J., Chadalavada, R.S., Olshen, A.B., Dobrzynski, D., Reuter, V.E., Bosl, G.J., Chaganti, R.S. Cancer Res. (2006) [Pubmed]
  2. Phylogenetic relationships of the genera Stella, Labrys and Angulomicrobium within the 'Alphaproteobacteria' and description of Angulomicrobium amanitiforme sp. nov. Fritz, I., Strömpl, C., Abraham, W.R. Int. J. Syst. Evol. Microbiol. (2004) [Pubmed]
  3. Typhoid fever in Ujung Pandang, Indonesia--high-risk groups and high-risk behaviours. Velema, J.P., van Wijnen, G., Bult, P., van Naerssen, T., Jota, S. Trop. Med. Int. Health (1997) [Pubmed]
  4. Comparative analysis of different collagen-based biomaterials as scaffolds for long-term culture of human fibroblasts. Vaissiere, G., Chevallay, B., Herbage, D., Damour, O. Medical & biological engineering & computing. (2000) [Pubmed]
  5. Stella is a maternal effect gene required for normal early development in mice. Payer, B., Saitou, M., Barton, S.C., Thresher, R., Dixon, J.P., Zahn, D., Colledge, W.H., Carlton, M.B., Nakano, T., Surani, M.A. Curr. Biol. (2003) [Pubmed]
  6. Neuropsychological deficits and neural dysfunction in familial dyslexia. Brambati, S.M., Termine, C., Ruffino, M., Danna, M., Lanzi, G., Stella, G., Cappa, S.F., Perani, D. Brain Res. (2006) [Pubmed]
  7. PGC7/Stella protects against DNA demethylation in early embryogenesis. Nakamura, T., Arai, Y., Umehara, H., Masuhara, M., Kimura, T., Taniguchi, H., Sekimoto, T., Ikawa, M., Yoneda, Y., Okabe, M., Tanaka, S., Shiota, K., Nakano, T. Nat. Cell Biol. (2007) [Pubmed]
  8. Adult tissue-specific expression of a Dppa3-derived retrogene represents a postnatal transcript of pluripotent cell origin. Elliman, S.J., Wu, I., Kemp, D.M. J. Biol. Chem. (2006) [Pubmed]
  9. Diverse epigenetic profile of novel human embryonic stem cell lines. Lagarkova, M.A., Volchkov, P.Y., Lyakisheva, A.V., Philonenko, E.S., Kiselev, S.L. Cell Cycle (2006) [Pubmed]
  10. Modeling intestinal absorption and other nutrition-related processes using PSPICE and STELLA. Mikulecky, D.C. J. Pediatr. Gastroenterol. Nutr. (1990) [Pubmed]
  11. Evaluation of the performance of controlled release dosage forms of ticlopidine using in vitro intestinal permeability and computer simulations. Grass, G.M., Bozarth, C.A., Vallner, J.J. Journal of drug targeting. (1994) [Pubmed]
  12. Dppa3 is a marker of pluripotency and has a human homologue that is expressed in germ cell tumours. Bowles, J., Teasdale, R.P., James, K., Koopman, P. Cytogenet. Genome Res. (2003) [Pubmed]
  13. The effects of dialysis on 131I kinetics and dosimetry in thyroid cancer patients--a pharmacokinetic model. Pahlka, R.B., Sonnad, J.R. Health physics. (2006) [Pubmed]
  14. Ocular pharmacokinetic modeling using corneal absorption and desorption rates from in vitro permeation experiments with cultured corneal epithelial cells. Ranta, V.P., Laavola, M., Toropainen, E., Vellonen, K.S., Talvitie, A., Urtti, A. Pharm. Res. (2003) [Pubmed]
  15. Determination of physicochemical properties, stability in aqueous solutions and serum hydrolysis of pilocarpic acid diesters. Järvinen, T., Suhonen, P., Naumanen, H., Urtti, A., Peura, P. Journal of pharmaceutical and biomedical analysis. (1991) [Pubmed]
  16. Investigation into the importance of the stomatal pathway in the exchange of PCBs between air and plants. Barber, J.L., Kurt, P.B., Thomas, G.O., Kerstiens, G., Jones, K.C. Environ. Sci. Technol. (2002) [Pubmed]
  17. Endometrial involvement by intra-abdominal diffuse malignant mesothelioma. Kir, G., Kir, M., Karateke, A., Ozkan, F. Eur. J. Gynaecol. Oncol. (2004) [Pubmed]
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