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Gene Review

ITGA3  -  integrin, alpha 3 (antigen CD49C, alpha 3...

Homo sapiens

Synonyms: CD49 antigen-like family member C, CD49C, CD49c, FRP-2, GAP-B3, ...
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Disease relevance of ITGA3


High impact information on ITGA3

  • Anti-FRP-1 mAb immunoprecipitated gp80-85, gp120 and homodimers of these peptides, and anti-FRP-2 mAb reacted with gp135 identically to the alpha 3 subunit of integrin [4].
  • When activated by genotoxic stress or overexpressed ectopically in non-adherent cells, p51/p63 transduced a phenotype to attach to extracellular matrices, which was accompanied by expression of ITGA3 [5].
  • Additionally, the migratory CD4+ T cell population is largely CD58bright, CD31-, CD62L-, and is also enriched in cells that brightly express CD49c, CD49e, and CD49f [6].
  • IL-6 induced expression of CD49b (alpha-chain of VLA-2, 20% +/- 11 vs 2% +/- 1) and CD49c (alpha-chain of VLA-3, 43% +/- 17 vs 5% +/- 3), which are not expressed on resting NK cells [7].
  • CAP37 upregulated intercellular adhesion molecule (ICAM)-1, platelet endothelial cell adhesion molecule (PECAM)-1, and integrin molecules alpha3 (CD49c) and beta1 (CD29) [8].

Biological context of ITGA3


Anatomical context of ITGA3


Associations of ITGA3 with chemical compounds

  • CONCLUSIONS: In vivo selection and flow cytometric analysis revealed that Lea, sLea, CD49b, CD49c, and CD29 appear to be involved in the increase of metastatic activity [14].
  • Identification of human galactoprotein b3, an oncogenic transformation-induced membrane glycoprotein, as VLA-3 alpha subunit: the primary structure of human integrin alpha 3 [9].
  • Based on this sequence identity and the structural similarities (i.e. the positions of most cysteine residues, the presence of a transmembrane domain near the C-terminus and the presence of metal binding sequences) with other integrins so far cloned, we conclude that human galactoprotein b3 is an integrin alpha 3 subunit [9].

Other interactions of ITGA3

  • We investigated this by studying the expression of the beta1-integrin chains CD29 and CD49c, -d, -e, and -f, on in vitro HIV-infected primary T cells [15].
  • In pre-B ALL, expression of CD11a positively correlated with that of CD11b (P < .05) and CD54 (P < .01), and CD49c positively correlated with CD49f (P < .01) [16].

Analytical, diagnostic and therapeutic context of ITGA3

  • In the present study, we examined the change in the amounts of mRNA for the mouse and human counterparts in fibroblasts after oncogenic transformation by Northern blot analysis using hamster galactoprotein b3 cDNA as a probe [9].
  • Since VCA-2 is found predominantly on the basal membrane of adherent cells and its expression increases 12-fold when HUT-102 lymphoblastoid cells are grown as an adherent cell culture, we suggest that VCA-2 plays a role in cellular adherence [17].


  1. Adhesion molecule profiles of B-cell non-Hodgkin's lymphomas in the leukemic phase. Matos, D.M., Rizzatti, E.G., Garcia, A.B., Gallo, D.A., Falc??o, R.P. Braz. J. Med. Biol. Res. (2006) [Pubmed]
  2. DNA-mediated gene transfer of a human cell surface 170-kilodalton glycoprotein. Evidence for association with an endogenous murine protein. Kantor, R.R., Bander, N.H., Finstad, C.L., Graf, L.H., Lloyd, K.O., Old, L.J., Albino, A.P. J. Biol. Chem. (1987) [Pubmed]
  3. Loss of VLA-3 (CD49c/CD29) expression in two multidrug resistant Burkitt's lymphoma cell lines. Duensing, S., Duensing, A., Grosse, J., Atzpodien, J. Cancer Biother. Radiopharm. (1998) [Pubmed]
  4. Molecular and biological characterization of fusion regulatory proteins (FRPs): anti-FRP mAbs induced HIV-mediated cell fusion via an integrin system. Ohta, H., Tsurudome, M., Matsumura, H., Koga, Y., Morikawa, S., Kawano, M., Kusugawa, S., Komada, H., Nishio, M., Ito, Y. EMBO J. (1994) [Pubmed]
  5. p51/p63 Controls subunit alpha3 of the major epidermis integrin anchoring the stem cells to the niche. Kurata, S., Okuyama, T., Osada, M., Watanabe, T., Tomimori, Y., Sato, S., Iwai, A., Tsuji, T., Ikawa, Y., Katoh, I. J. Biol. Chem. (2004) [Pubmed]
  6. Phenotypic characterization of CD4+ T cells that exhibit a transendothelial migratory capacity. Brezinschek, R.I., Lipsky, P.E., Galea, P., Vita, R., Oppenheimer-Marks, N. J. Immunol. (1995) [Pubmed]
  7. Response of human NK cells to IL-6 alterations of the cell surface phenotype, adhesion to fibronectin and laminin, and tumor necrosis factor-alpha/beta secretion. Rabinowich, H., Sedlmayr, P., Herberman, R.B., Whiteside, T.L. J. Immunol. (1993) [Pubmed]
  8. Modulation of corneal epithelial cell functions by the neutrophil-derived inflammatory mediator CAP37. Pereira, H.A., Ruan, X., Gonzalez, M.L., Tsyshevskaya-Hoover, I., Chodosh, J. Invest. Ophthalmol. Vis. Sci. (2004) [Pubmed]
  9. Identification of human galactoprotein b3, an oncogenic transformation-induced membrane glycoprotein, as VLA-3 alpha subunit: the primary structure of human integrin alpha 3. Tsuji, T., Hakomori, S., Osawa, T. J. Biochem. (1991) [Pubmed]
  10. Establishment of feather follicle stem cells as potential vehicles for delivering exogenous genes in birds. Xi, Y., Nada, Y., Soh, T., Fujihara, N., Hattori, M.A. J. Reprod. Dev. (2003) [Pubmed]
  11. In vitro effect of transforming growth factor-beta on adhesion molecule expression by human gingival fibroblasts cultured in the presence of a titanium abutment. Schierano, G., Bellone, G., Manzella, C., Preti, G., Emanuelli, G. J. Periodontol. (2001) [Pubmed]
  12. Expression of homing receptors and related molecules on human mast cells and basophils: a comparative analysis using multi-color flow cytometry and toluidine blue/immunofluorescence staining techniques. Wimazal, F., Ghannadan, M., Müller, M.R., End, A., Willheim, M., Meidlinger, P., Schernthaner, G.H., Jordan, J.H., Hagen, W., Agis, H., Sperr, W.R., Czerwenka, K., Lechner, K., Valent, P. Tissue Antigens (1999) [Pubmed]
  13. Human blood dendritic cells: binding to vascular endothelium and expression of adhesion molecules. Brown, K.A., Bedford, P., Macey, M., McCarthy, D.A., Leroy, F., Vora, A.J., Stagg, A.J., Dumonde, D.C., Knight, S.C. Clin. Exp. Immunol. (1997) [Pubmed]
  14. Enhancement of metastatic activity of colon cancer as influenced by expression of cell surface antigens. Okazaki, K., Nakayama, Y., Shibao, K., Hirata, K., Nagata, N., Itoh, H. J. Surg. Res. (1998) [Pubmed]
  15. Quantitative study of beta1-integrin expression and fibronectin interaction profile of T lymphocytes in vitro infected with HIV. Leblond, V., Legendre, C., Gras, G., Dereuddre-Bosquet, N., Lafuma, C., Dormont, D. AIDS Res. Hum. Retroviruses (2000) [Pubmed]
  16. Expression of adhesion molecules in childhood B-lineage-cell neoplasms. Hara, J., Matsuda, Y., Fujisaki, H., Tokimasa, S., Ohta, H., Osagi, Y., Takai, K. Int. J. Hematol. (2000) [Pubmed]
  17. Biochemical analysis of two cell surface glycoprotein complexes, very common antigen 1 and very common antigen 2. Relationship to very late activation T cell antigens. Kantor, R.R., Mattes, M.J., Lloyd, K.O., Old, L.J., Albino, A.P. J. Biol. Chem. (1987) [Pubmed]
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