Gene Review:
ITGA2 - integrin, alpha 2 (CD49B, alpha 2 subunit...
Homo sapiens
Synonyms:
BR, CD49 antigen-like family member B, CD49B, CD49b, Collagen receptor, ...
Cenni,
Granchi,
Verri,
Remiddi,
Cavedagna,
Di Leo,
Di Paola,
Jugessur,
Goldman,
Reiland,
Tallman,
Sayago,
Murray,
Kallio,
Mikkelsson,
Tammela,
Karhunen,
Kellokumpu-Lehtinen,
Kunicki,
Federici,
Salomon,
Koziol,
Head,
Mondala,
Chismar,
Baronciani,
Canciani,
Peake,
Kurita-Ochiai,
Seto,
Ochiai,
Nishiya,
Kainoh,
Murata,
Handa,
Ikeda,
Ciarlet,
Crawford,
Cheng,
Blutt,
Rice,
Bergelson,
Estes,
Pereira,
Quiroga,
Pereira,
Morales,
Goycoolea,
Hidalgo,
Prieto,
Mezzano,
Wang,
Holcslaw,
Bashore,
Freed,
Miller,
Rudnick,
Szerlip,
Thames,
Davidson,
Shusterman,
Schwab,
- Platelet glycoprotein I(b)alpha and integrin alpha2 beta1 polymorphisms: gene frequencies and linkage disequilibrium in a population diversity panel. Di Paola, J., Jugessur, A., Goldman, T., Reiland, J., Tallman, D., Sayago, C., Murray, J.C. J. Thromb. Haemost. (2005)
- Correlation of very late activation integrin and CD44 expression with extrarenal invasion and metastasis of renal cell carcinomas. Gilcrease, M.Z., Truong, L., Brown, R.W. Hum. Pathol. (1996)
- In vivo distribution of integrins in renal cell carcinoma: integrin-phenotype alteration in different degrees of tumor differentiation and VLA-2 involvement in tumor metastasis. Anastassiou, G., Duensing, S., Steinhoff, G., Kirchner, H., Ganser, A., Atzpodien, J. Cancer Biother. (1995)
- Role of membrane glycoproteins in the interaction of blood platelets with the vessel wall--the study on platelet adhesion to in vitro cultured subendothelial matrix. Kawai, Y., Handa, M., Nagai, H., Kamata, T., Anbo, H., Kawano, K., Araki, Y., Yamamoto, M., Ikeda, Y., Watanabe, K. Nippon Ketsueki Gakkai Zasshi (1989)
- Integrin alpha-2 and beta-3 gene polymorphisms and breast cancer risk. Langsenlehner, U., Renner, W., Yazdani-Biuki, B., Eder, T., Wascher, T.C., Paulweber, B., Clar, H., Hofmann, G., Samonigg, H., Krippl, P. Breast Cancer Res. Treat. (2006)
- Targeted and natural (piebald-lethal) mutations of endothelin-B receptor gene produce megacolon associated with spotted coat color in mice. Hosoda, K., Hammer, R.E., Richardson, J.A., Baynash, A.G., Cheung, J.C., Giaid, A., Yanagisawa, M. Cell (1994)
- Integrin alpha 2 beta 1 (VLA-2) mediates reorganization and contraction of collagen matrices by human cells. Schiro, J.A., Chan, B.M., Roswit, W.T., Kassner, P.D., Pentland, A.P., Hemler, M.E., Eisen, A.Z., Kupper, T.S. Cell (1991)
- Differential activation by atrial and brain natriuretic peptides of two different receptor guanylate cyclases. Chang, M.S., Lowe, D.G., Lewis, M., Hellmiss, R., Chen, E., Goeddel, D.V. Nature (1989)
- Fibronectin receptor structures in the VLA family of heterodimers. Takada, Y., Huang, C., Hemler, M.E. Nature (1987)
- Identification of the integrin VLA-2 as a receptor for echovirus 1. Bergelson, J.M., Shepley, M.P., Chan, B.M., Hemler, M.E., Finberg, R.W. Science (1992)
- VLA-2 (alpha2beta1) integrin promotes rotavirus entry into cells but is not necessary for rotavirus attachment. Ciarlet, M., Crawford, S.E., Cheng, E., Blutt, S.E., Rice, D.A., Bergelson, J.M., Estes, M.K. J. Virol. (2002)
- Low expression of beta 1, alpha 2 and alpha 3 subunits of VLA integrins in malignant mammary tumours. Pignatelli, M., Hanby, A.M., Stamp, G.W. J. Pathol. (1991)
- Vascular risk factors in sudden hearing loss. Rudack, C., Langer, C., Stoll, W., Rust, S., Walter, M. Thromb. Haemost. (2006)
- Exacerbation of radiocontrast nephrotoxicity by endothelin receptor antagonism. Wang, A., Holcslaw, T., Bashore, T.M., Freed, M.I., Miller, D., Rudnick, M.R., Szerlip, H., Thames, M.D., Davidson, C.J., Shusterman, N., Schwab, S.J. Kidney Int. (2000)
- An association of candidate gene haplotypes and bleeding severity in von Willebrand disease (VWD) type 1 pedigrees. Kunicki, T.J., Federici, A.B., Salomon, D.R., Koziol, J.A., Head, S.R., Mondala, T.S., Chismar, J.D., Baronciani, L., Canciani, M.T., Peake, I.R. Blood (2004)
- The primary structure of the VLA-2/collagen receptor alpha 2 subunit (platelet GPIa): homology to other integrins and the presence of a possible collagen-binding domain. Takada, Y., Hemler, M.E. J. Cell Biol. (1989)
- Platelet membrane glycoprotein polymorphisms do not influence the clinical expressivity of von Willebrand disease type 1. Pereira, J., Quiroga, T., Pereira, M.E., Morales, M., Goycoolea, M., Hidalgo, P., Prieto, C., Mezzano, D. Thromb. Haemost. (2003)
- Role of cell-cell communication in inhibiting butyric acid-induced T-cell apoptosis. Kurita-Ochiai, T., Seto, S., Ochiai, K. Infect. Immun. (2004)
- Extracellular matrix receptors and the differentiation of human megakaryocytes in vitro. Molla, A., Mossuz, P., Berthier, R. Leuk. Lymphoma (1999)
- Freezing adhesion molecules in a state of high-avidity binding blocks eosinophil migration. Kuijpers, T.W., Mul, E.P., Blom, M., Kovach, N.L., Gaeta, F.C., Tollefson, V., Elices, M.J., Harlan, J.M. J. Exp. Med. (1993)
- Response of human NK cells to IL-6 alterations of the cell surface phenotype, adhesion to fibronectin and laminin, and tumor necrosis factor-alpha/beta secretion. Rabinowich, H., Sedlmayr, P., Herberman, R.B., Whiteside, T.L. J. Immunol. (1993)
- Human epidermal Langerhans cells express integrins of the beta 1 subfamily. Le Varlet, B., Dezutter-Dambuyant, C., Staquet, M.J., Delorme, P., Schmitt, D. J. Invest. Dermatol. (1991)
- Expression of integrins in junctional and dystrophic epidermolysis bullosa. Nazzaro, V., Berti, E., Cerri, A., Brusasco, A., Cavalli, R., Caputo, R. J. Invest. Dermatol. (1990)
- Beta-1 integrin cell adhesion molecules in the endometrium of fertile and infertile women. Klentzeris, L.D., Bulmer, J.N., Trejdosiewicz, L.K., Morrison, L., Cooke, I.D. Hum. Reprod. (1993)
- Reconstitution of adhesive properties of human platelets in liposomes carrying both recombinant glycoproteins Ia/IIa and Ib alpha under flow conditions: specific synergy of receptor-ligand interactions. Nishiya, T., Kainoh, M., Murata, M., Handa, M., Ikeda, Y. Blood (2002)
- Evaluation of endothelial cell integrins after in \ vitro contact with polyethylene terephthalate. Cenni, E., Granchi, D., Verri, E., Remiddi, G., Cavedagna, D., Di Leo, A. Journal of materials science. Materials in medicine. (2001)
- Genetic variation in platelet integrin alphabeta (GPIIb/IIIa) and the metastatic potential of renal cell carcinoma. Kallio, J.P., Mikkelsson, J., Tammela, T.L., Karhunen, P.J., Kellokumpu-Lehtinen, P. BJU Int. (2006)
- Enhancement of metastatic activity of colon cancer as influenced by expression of cell surface antigens. Okazaki, K., Nakayama, Y., Shibao, K., Hirata, K., Nagata, N., Itoh, H. J. Surg. Res. (1998)
- Collagen-platelet interactions: evidence for a direct interaction of collagen with platelet GPIa/IIa and an indirect interaction with platelet GPIIb/IIIa mediated by adhesive proteins. Coller, B.S., Beer, J.H., Scudder, L.E., Steinberg, M.H. Blood (1989)
- Expression of VLA-alpha 2, VLA-alpha 6, and VLA-beta 1 chains in normal mucosa and adenomas of the colon, and in colon carcinomas and their liver metastases. Koretz, K., Schlag, P., Boumsell, L., Möller, P. Am. J. Pathol. (1991)
- Distinct molecular mechanisms for agonist peptide binding to types A and B cholecystokinin receptors demonstrated using fluorescence spectroscopy. Harikumar, K.G., Clain, J., Pinon, D.I., Dong, M., Miller, L.J. J. Biol. Chem. (2005)
- Expression and function of fibronectin receptors on peripheral mononuclear cells in IgA nephropathy. Namie, S., Ozono, Y., Harada, T., Hara, K. Nephrol. Dial. Transplant. (1995)
- Endothelin-1 potentiates human smooth muscle cell growth to PDGF: effects of ETA and ETB receptor blockade. Yang, Z., Krasnici, N., Lüscher, T.F. Circulation (1999)
- VLA-1: a T cell surface antigen which defines a novel late stage of human T cell activation. Hemler, M.E., Jacobson, J.G., Brenner, M.B., Mann, D., Strominger, J.L. Eur. J. Immunol. (1985)
- Identification of specific human epithelial cell integrin receptors as VLA proteins. Staquet, M.J., Levarlet, B., Dezutter-Dambuyant, C., Schmitt, D., Thivolet, J. Exp. Cell Res. (1990)
- Adhesion molecules in normal human conjunctiva. An immunohistological study using monoclonal antibodies. Vorkauf, M., Duncker, G., Nölle, B., Sterry, W. Graefes Arch. Clin. Exp. Ophthalmol. (1993)
- The human platelet alloantigens Br(a) and Brb are associated with a single amino acid polymorphism on glycoprotein Ia (integrin subunit alpha 2). Santoso, S., Kalb, R., Walka, M., Kiefel, V., Mueller-Eckhardt, C., Newman, P.J. J. Clin. Invest. (1993)
- Identification of integrin collagen receptors on human melanoma cells. Kramer, R.H., Marks, N. J. Biol. Chem. (1989)
- Localization of the Br polymorphism on a 144 bp exon of the GPIa gene and its application in platelet DNA typing. Kalb, R., Santoso, S., Unkelbach, K., Kiefel, V., Mueller-Eckhardt, C. Thromb. Haemost. (1994)
- Altered expression of beta 1 integrins in renal carcinoma cell lines exposed to vinblastine. Meyer, N., Duensing, S., Anastassiou, G., Brevis Nunez, F., Grosse, J., Ganser, A., Atzpodien, J. Anticancer Res. (1999)