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Gene Review

Itga3  -  integrin alpha 3

Mus musculus

Synonyms: AA407068, CD49 antigen-like family member C, CD49C, GAPB3, Galactoprotein B3, ...
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Disease relevance of Itga3


High impact information on Itga3


Chemical compound and disease context of Itga3


Biological context of Itga3


Anatomical context of Itga3


Associations of Itga3 with chemical compounds


Regulatory relationships of Itga3

  • These results suggest that the Sp3 and Ets transcription factors cooperatively regulate alpha3 integrin gene expression and that the contribution of each element depends on the type of tumor cells [25].

Other interactions of Itga3

  • Protein sequence analysis revealed that p225 consists of two polypeptides, namely integrin alpha 3 heavy chain (approximately 130 kDa) disulphide-bonded to a monomer of the transferrin receptor (approximately 95 kDa) instead of the typical alpha 3 light chain (approximately 25 kDa) [21].
  • These changes in laminin mRNAs were parallel with its receptors such as integrin alpha 3 and alpha 6 [26].
  • Other known components of the pathway include members of the lipoprotein receptor family, the intracellular adaptor Dab1, and possibly integrin alpha 3 beta 1 [27].
  • After a 5-day culture period the number of fibroblast-like cells with alpha 1-, alpha v- and alpha 5 beta 1-integrins had increased. alpha 3-integrin was hardly recognizable on these cells [28].

Analytical, diagnostic and therapeutic context of Itga3


  1. Podocyte migration during nephrotic syndrome requires a coordinated interplay between cathepsin L and alpha3 integrin. Reiser, J., Oh, J., Shirato, I., Asanuma, K., Hug, A., Mundel, T.M., Honey, K., Ishidoh, K., Kominami, E., Kreidberg, J.A., Tomino, Y., Mundel, P. J. Biol. Chem. (2004) [Pubmed]
  2. A peptide model of basement membrane collagen alpha 1 (IV) 531-543 binds the alpha 3 beta 1 integrin. Miles, A.J., Knutson, J.R., Skubitz, A.P., Furcht, L.T., McCarthy, J.B., Fields, G.B. J. Biol. Chem. (1995) [Pubmed]
  3. Integrin alpha3beta1 expressed by human colon cancer cells is a major carrier of oncodevelopmental carbohydrate epitopes. Prokopishyn, N.L., Puzon-McLaughlin, W., Takada, Y., Laferté, S. J. Cell. Biochem. (1999) [Pubmed]
  4. Organization of focal adhesion plaques is disrupted by action of the HIV-1 protease. Shoeman, R.L., Hartig, R., Hauses, C., Traub, P. Cell Biol. Int. (2002) [Pubmed]
  5. Identification of a TLR-independent pathway for Borrelia burgdorferi-induced expression of matrix metalloproteinases and inflammatory mediators through binding to integrin alpha 3 beta 1. Behera, A.K., Hildebrand, E., Uematsu, S., Akira, S., Coburn, J., Hu, L.T. J. Immunol. (2006) [Pubmed]
  6. Disabled-1-regulated adhesion of migrating neurons to radial glial fiber contributes to neuronal positioning during early corticogenesis. Sanada, K., Gupta, A., Tsai, L.H. Neuron (2004) [Pubmed]
  7. Transcriptional induction of slit diaphragm genes by Lmx1b is required in podocyte differentiation. Miner, J.H., Morello, R., Andrews, K.L., Li, C., Antignac, C., Shaw, A.S., Lee, B. J. Clin. Invest. (2002) [Pubmed]
  8. Distinct functions of alpha3 and alpha(v) integrin receptors in neuronal migration and laminar organization of the cerebral cortex. Anton, E.S., Kreidberg, J.A., Rakic, P. Neuron (1999) [Pubmed]
  9. Reelin function in neural stem cell biology. Kim, H.M., Qu, T., Kriho, V., Lacor, P., Smalheiser, N., Pappas, G.D., Guidotti, A., Costa, E., Sugaya, K. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  10. alpha3beta1 integrin modulates neuronal migration and placement during early stages of cerebral cortical development. Schmid, R.S., Shelton, S., Stanco, A., Yokota, Y., Kreidberg, J.A., Anton, E.S. Development (2004) [Pubmed]
  11. Colonization of human lung grafts in SCID-hu mice by human colon carcinoma cells. Sampson-Johannes, A., Wang, W., Shtivelman, E. Int. J. Cancer (1996) [Pubmed]
  12. Alpha 3 beta 1 integrin promotes keratinocyte cell survival through activation of a MEK/ERK signaling pathway. Manohar, A., Shome, S.G., Lamar, J., Stirling, L., Iyer, V., Pumiglia, K., DiPersio, C.M. J. Cell. Sci. (2004) [Pubmed]
  13. Loss of alpha3beta1 integrin function results in an altered differentiation program in the mouse submandibular gland. Menko, A.S., Kreidberg, J.A., Ryan, T.T., Van Bockstaele, E., Kukuruzinska, M.A. Dev. Dyn. (2001) [Pubmed]
  14. Characterization of the promoter for the mouse alpha 3 integrin gene. Kato, T., Katabami, K., Takatsuki, H., Han, S.A., Takeuchi, K., Irimura, T., Tsuji, T. Eur. J. Biochem. (2002) [Pubmed]
  15. Integrin requirement for hippocampal synaptic plasticity and spatial memory. Chan, C.S., Weeber, E.J., Kurup, S., Sweatt, J.D., Davis, R.L. J. Neurosci. (2003) [Pubmed]
  16. Branching morphogenesis of human mammary epithelial cells in collagen gels. Berdichevsky, F., Alford, D., D'Souza, B., Taylor-Papadimitriou, J. J. Cell. Sci. (1994) [Pubmed]
  17. Stem cell factor regulates human melanocyte-matrix interactions. Scott, G., Ewing, J., Ryan, D., Abboud, C. Pigment Cell Res. (1994) [Pubmed]
  18. Neuronal receptors mediating responses to antibodyactivated laminin-1. Ivins, J.K., Colognato, H., Kreidberg, J.A., Yurchenco, P.D., Lander, A.D. J. Neurosci. (1998) [Pubmed]
  19. A cell signal pathway involving laminin-5, alpha3beta1 integrin, and mitogen-activated protein kinase can regulate epithelial cell proliferation. Gonzales, M., Haan, K., Baker, S.E., Fitchmun, M., Todorov, I., Weitzman, S., Jones, J.C. Mol. Biol. Cell (1999) [Pubmed]
  20. None of the integrins known to be present on the mouse egg or to be ADAM receptors are essential for sperm-egg binding and fusion. He, Z.Y., Brakebusch, C., Fässler, R., Kreidberg, J.A., Primakoff, P., Myles, D.G. Dev. Biol. (2003) [Pubmed]
  21. Identification of a novel form of the alpha 3 integrin subunit: covalent association with transferrin receptor. Coppolino, M., Migliorini, M., Argraves, W.S., Dedhar, S. Biochem. J. (1995) [Pubmed]
  22. The receptor for the basement membrane glycoprotein entactin is the integrin alpha 3/beta 1. Dedhar, S., Jewell, K., Rojiani, M., Gray, V. J. Biol. Chem. (1992) [Pubmed]
  23. Formation of hemidesmosomes in cells of a transformed murine mammary tumor cell line and mechanisms involved in adherence of these cells to laminin and kalinin. Sonnenberg, A., de Melker, A.A., Martinez de Velasco, A.M., Janssen, H., Calafat, J., Niessen, C.M. J. Cell. Sci. (1993) [Pubmed]
  24. Quantitative switch in integrin expression accompanies differentiation of F9 cells treated with retinoic acid. Burdsal, C.A., Lotz, M.M., Miller, J., McClay, D.R. Dev. Dyn. (1994) [Pubmed]
  25. Characterization of the promoter for the alpha3 integrin gene in various tumor cell lines: roles of the Ets- and Sp-family of transcription factors. Katabami, K., Kato, T., Sano, R., Ogura, M., Mizuno, H., Itoh, S., Tsuji, T. J. Cell. Biochem. (2006) [Pubmed]
  26. Differential expression of laminin chain-specific mRNA transcripts during mouse preimplantation embryo development. Shim, C., Kwon, H.B., Kim, K. Mol. Reprod. Dev. (1996) [Pubmed]
  27. Neuronal migration. Lambert de Rouvroit, C., Goffinet, A.M. Mech. Dev. (2001) [Pubmed]
  28. Integrin expression on epiphyseal mouse chondrocytes in monolayer culture. Shakibaei, M. Histol. Histopathol. (1995) [Pubmed]
  29. Modulation of integrin-laminin receptor function on mammary tumor cells by prostaglandin E2 receptor antagonism. Zhang, S.Z., Fulton, A.M. Cancer Lett. (1994) [Pubmed]
  30. Pancreatic carcinomas deposit laminin-5, preferably adhere to laminin-5, and migrate on the newly deposited basement membrane. Tani, T., Lumme, A., Linnala, A., Kivilaakso, E., Kiviluoto, T., Burgeson, R.E., Kangas, L., Leivo, I., Virtanen, I. Am. J. Pathol. (1997) [Pubmed]
  31. Near-infrared optical imaging of ovarian cancer xenografts with novel alpha 3-integrin binding peptide "OA02". Aina, O.H., Marik, J., Gandour-Edwards, R., Lam, K.S. Molecular imaging : official journal of the Society for Molecular Imaging. (2005) [Pubmed]
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