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Gene Review

SELL  -  selectin L

Homo sapiens

Synonyms: CD62 antigen-like family member L, CD62L, L-selectin, LAM-1, LAM1, ...
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Disease relevance of SELL


Psychiatry related information on SELL


High impact information on SELL


Chemical compound and disease context of SELL


Biological context of SELL


Anatomical context of SELL


Associations of SELL with chemical compounds

  • The loss of CD162 and CD62L expression was inhibited by EDTA, which suggests that neutrophil activation and sheddase cleavage occurred [24].
  • RESULTS: Percentages of PB non-CD3, CD56+ NK cells, but not CD3+ T cells, increased in asthmatic children with acute exacerbation, compared to those assessed in a stable condition after a course of prednisolone [25].
  • In vitro data have shown that cryptococcal polysaccharide induces L-selectin (CD62L) shedding from leukocytes [26].
  • Two-color immunofluorescence analyses of adhesion molecules such as alpha x beta 2 integrin (LeuM5) and L-selectin (Leu8) showed that these markers were detectable on variable proportions of leukemic cells, thus confirming the intraclonal phenotypic heterogeneity of B-CLL [27].
  • Histamine release was optimal at 0.3 microgram/ml anti-IgE, and at superoptimal concentrations, reduced CD11b expression was observed which paralleled decreases in histamine release; reduction of the expression of Leu 8, however, occurred equally at optimal and superoptimal concentrations of anti-IgE [28].

Regulatory relationships of SELL


Other interactions of SELL


Analytical, diagnostic and therapeutic context of SELL


  1. Gingipains of Porphyromonas gingivalis modulate leukocyte adhesion molecule expression induced in human endothelial cells by ligation of CD99. Yun, P.L., Decarlo, A.A., Hunter, N. Infect. Immun. (2006) [Pubmed]
  2. Immunohistological examination of the relationship between metastatic potential and expression of adhesion molecules and 'selectins' on melanoma cells. Si, Z., Hersey, P. Pathology. (1994) [Pubmed]
  3. CXCR4 engagement is required for HIV-1-induced L-selectin shedding. Wang, J., Marschner, S., Finkel, T.H. Blood (2004) [Pubmed]
  4. Cutting edge: L-selectin (CD62L) expression distinguishes small resting memory CD4+ T cells that preferentially respond to recall antigen. Hengel, R.L., Thaker, V., Pavlick, M.V., Metcalf, J.A., Dennis, G., Yang, J., Lempicki, R.A., Sereti, I., Lane, H.C. J. Immunol. (2003) [Pubmed]
  5. Structure of the gene encoding the human leukocyte adhesion molecule-1 (TQ1, Leu-8) of lymphocytes and neutrophils. Ord, D.C., Ernst, T.J., Zhou, L.J., Rambaldi, A., Spertini, O., Griffin, J., Tedder, T.F. J. Biol. Chem. (1990) [Pubmed]
  6. Acute psychological stress and exercise and changes in peripheral leukocyte adhesion molecule expression and density. Goebel, M.U., Mills, P.J. Psychosomatic medicine. (2000) [Pubmed]
  7. Pituitary-adrenal-immune system in normal subjects and in patients with anorexia nervosa: the number of circulating helper T lymphocytes (CD4) expressing the homing receptor Leu8 is regulated in part by pituitary-adrenal products. Chiappelli, F., Gwirtsman, H.E., Lowy, M., Gormley, G., Nguyen, L.D., Nguyen, L., Popow, J., Esmail, I., Fahey, J.L., Strober, M. Psychoneuroendocrinology (1991) [Pubmed]
  8. Colostrum composition in adolescent mothers. Vitolo, M.R., Brasil, A.L., Lopez, F.A., de Nóbrega, F.J. Journal of the American College of Nutrition. (1993) [Pubmed]
  9. Cell-surface expression of L-selectin (CD62L) by blood lymphocytes: correlates with affective parameters and severity of panic disorder. Manfro, G.G., Pollack, M.H., Otto, M.W., Worthington, J.J., Rosenbaum, J.F., Scott, E.L., Kradin, R.L. Depression and anxiety. (2000) [Pubmed]
  10. A central role for microvillous receptor presentation in leukocyte adhesion under flow. von Andrian, U.H., Hasslen, S.R., Nelson, R.D., Erlandsen, S.L., Butcher, E.C. Cell (1995) [Pubmed]
  11. Histidine phosphorylation of P-selectin upon stimulation of human platelets: a novel pathway for activation-dependent signal transduction. Crovello, C.S., Furie, B.C., Furie, B. Cell (1995) [Pubmed]
  12. The neutrophil selectin LECAM-1 presents carbohydrate ligands to the vascular selectins ELAM-1 and GMP-140. Picker, L.J., Warnock, R.A., Burns, A.R., Doerschuk, C.M., Berg, E.L., Butcher, E.C. Cell (1991) [Pubmed]
  13. Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type I interferon. Cella, M., Jarrossay, D., Facchetti, F., Alebardi, O., Nakajima, H., Lanzavecchia, A., Colonna, M. Nat. Med. (1999) [Pubmed]
  14. R5 variants of human immunodeficiency virus type 1 preferentially infect CD62L- CD4+ T cells and are potentially resistant to nucleoside reverse transcriptase inhibitors. Gondois-Rey, F., Biancotto, A., Fernandez, M.A., Bettendroffer, L., Blazkova, J., Trejbalova, K., Pion, M., Hirsch, I. J. Virol. (2006) [Pubmed]
  15. Peripheral blood mononuclear cell CD62L and CD11a expression and soluble interstitial cell adhesion molecule-1 levels following infused isoproterenol in hypertension. Mills, P.J., Farag, N.H., Perez, C., Dimsdale, J.E. J. Hypertens. (2002) [Pubmed]
  16. Expression of beta 1-integrins, H-CAM (CD44) and LECAM-1 in primary gastro-intestinal B-cell lymphomas as compared to the adhesion receptor profile of the gut-associated lymphoid system, tonsil and peripheral lymph node. Möller, P., Eichelmann, A., Mechtersheimer, G., Koretz, K. Int. J. Cancer (1991) [Pubmed]
  17. Soluble cellular adhesion molecules, selectins, VEGF and endothelin-1 in patients with Wuchereria bancrofti infection and association with clinical status. Esterre, P., Plichart, C., Huin-Blondey, M.O., Nguyen, L.N. Parasite Immunol. (2005) [Pubmed]
  18. Release of pro-inflammatory mediators during myocardial ischemia/reperfusion in coronary artery bypass graft surgery. Sharma, M., Ganguly, N.K., Chaturvedi, G., Thingnam, S.K., Majumdar, S., Suri, R.K. Mol. Cell. Biochem. (2003) [Pubmed]
  19. Granulocyte-macrophage colony-stimulating factor and other cytokines regulate surface expression of the leukocyte adhesion molecule-1 on human neutrophils, monocytes, and their precursors. Griffin, J.D., Spertini, O., Ernst, T.J., Belvin, M.P., Levine, H.B., Kanakura, Y., Tedder, T.F. J. Immunol. (1990) [Pubmed]
  20. FMC46, a cell protrusion-associated leukocyte adhesion molecule-1 epitope on human lymphocytes and thymocytes. Pilarski, L.M., Turley, E.A., Shaw, A.R., Gallatin, W.M., Laderoute, M.P., Gillitzer, R., Beckman, I.G., Zola, H. J. Immunol. (1991) [Pubmed]
  21. Isolation and chromosomal localization of cDNAs encoding a novel human lymphocyte cell surface molecule, LAM-1. Homology with the mouse lymphocyte homing receptor and other human adhesion proteins. Tedder, T.F., Isaacs, C.M., Ernst, T.J., Demetri, G.D., Adler, D.A., Disteche, C.M. J. Exp. Med. (1989) [Pubmed]
  22. Characterization of a human homologue of the murine peripheral lymph node homing receptor. Bowen, B.R., Nguyen, T., Lasky, L.A. J. Cell Biol. (1989) [Pubmed]
  23. ITAM-based interaction of ERM proteins with Syk mediates signaling by the leukocyte adhesion receptor PSGL-1. Urzainqui, A., Serrador, J.M., Viedma, F., Yáñez-Mó, M., Rodríguez, A., Corbí, A.L., Alonso-Lebrero, J.L., Luque, A., Deckert, M., Vázquez, J., Sánchez-Madrid, F. Immunity (2002) [Pubmed]
  24. Diminished adhesion of Anaplasma phagocytophilum-infected neutrophils to endothelial cells is associated with reduced expression of leukocyte surface selectin. Choi, K.S., Garyu, J., Park, J., Dumler, J.S. Infect. Immun. (2003) [Pubmed]
  25. Decreased intercellular adhesion molecule-1 (CD54) and L-selectin (CD62L) expression on peripheral blood natural killer cells in asthmatic children with acute exacerbation. Lin, S.J., Chang, L.Y., Yan, D.C., Huang, Y.J., Lin, T.J., Lin, T.Y. Allergy (2003) [Pubmed]
  26. Levels of L-selectin (CD62L) on human leukocytes in disseminated cryptococcosis with and without associated HIV-1 infection. Jackson, L.A., Drevets, D.A., Dong, Z.M., Greenfield, R.A., Murphy, J.W. J. Infect. Dis. (2005) [Pubmed]
  27. Adhesion molecule expression on B-cell chronic lymphocytic leukemia cells: malignant cell phenotypes define distinct disease subsets. De Rossi, G., Zarcone, D., Mauro, F., Cerruti, G., Tenca, C., Puccetti, A., Mandelli, F., Grossi, C.E. Blood (1993) [Pubmed]
  28. Altered surface expression of CD11 and Leu 8 during human basophil degranulation. Bochner, B.S., Sterbinsky, S.A. J. Immunol. (1991) [Pubmed]
  29. Distinctive pattern of cytokine production and adhesion molecule expression in peripheral blood memory CD4+ T cells from patients with active Crohn's disease. García de Tena, J., Manzano, L., Leal, J.C., San Antonio, E., Sualdea, V., Alvarez-Mon, M. J. Clin. Immunol. (2006) [Pubmed]
  30. Adhesion molecule expression on peripheral blood mononuclear cells in rheumatoid arthritis: positive correlation between the proportion of L-selectin and disease activity. Kurohori, Y., Sato, K., Suzuki, S., Kashiwazaki, S. Clin. Rheumatol. (1995) [Pubmed]
  31. Monocyte and neutrophil adhesion molecule expression during acute hyperglycemia and after antioxidant treatment in type 2 diabetes and control patients. Sampson, M.J., Davies, I.R., Brown, J.C., Ivory, K., Hughes, D.A. Arterioscler. Thromb. Vasc. Biol. (2002) [Pubmed]
  32. Functional re-expression of CCR7 on CMV-specific CD8+ T cells upon antigenic stimulation. van Leeuwen, E.M., van Buul, J.D., Remmerswaal, E.B., Hordijk, P.L., ten Berge, I.J., van Lier, R.A. Int. Immunol. (2005) [Pubmed]
  33. Heterogeneity of CD4 and CD8+ memory T cells in localized and generalized Wegener's granulomatosis. Lamprecht, P., Erdmann, A., Mueller, A., Csernok, E., Reinhold-Keller, E., Holl-Ulrich, K., Feller, A.C., Bruehl, H., Gross, W.L. Arthritis Res. Ther. (2003) [Pubmed]
  34. Elevated cyclic AMP inhibits endothelial cell synthesis and expression of TNF-induced endothelial leukocyte adhesion molecule-1, and vascular cell adhesion molecule-1, but not intercellular adhesion molecule-1. Pober, J.S., Slowik, M.R., De Luca, L.G., Ritchie, A.J. J. Immunol. (1993) [Pubmed]
  35. Leukocytes-depleting filters preferentially remove activated leukocytes and reduce the expression of surface adhesion molecules during the simulated extracorporeal circulation of human blood. Alexiou, C., Sheppard, S., Tang, A., Rengarajan, A., Smith, D., Haw, M., Gibbs, R. ASAIO J. (2006) [Pubmed]
  36. Leukocyte adhesion molecules as biocompatibility markers for hemodialysis membranes. von Appen, K., Goolsby, C., Mehl, P., Goewert, R., Ivanovich, P. ASAIO journal (American Society for Artificial Internal Organs : 1992) (1994) [Pubmed]
  37. Differential expression of tissue-specific adhesion molecules on human circulating antibody-forming cells after systemic, enteric, and nasal immunizations. A molecular basis for the compartmentalization of effector B cell responses. Quiding-Järbrink, M., Nordström, I., Granström, G., Kilander, A., Jertborn, M., Butcher, E.C., Lazarovits, A.I., Holmgren, J., Czerkinsky, C. J. Clin. Invest. (1997) [Pubmed]
  38. Molecular mapping of functional domains of the leukocyte receptor for endothelium, LAM-1. Kansas, G.S., Spertini, O., Stoolman, L.M., Tedder, T.F. J. Cell Biol. (1991) [Pubmed]
  39. Transition of late-stage effector T cells to CD27+ CD28+ tumor-reactive effector memory T cells in humans after adoptive cell transfer therapy. Powell, D.J., Dudley, M.E., Robbins, P.F., Rosenberg, S.A. Blood (2005) [Pubmed]
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