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Tbc1d2  -  TBC1 domain family, member 2

Mus musculus

Synonyms: A630005A06Rik, BC022630, Gm1037, LOC381605, PARIS-1, ...
 
 
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Disease relevance of Tbc1d2

  • The complete genome sequences of the human coronavirus OC43 (HCoV-OC43) laboratory strain from the American Type Culture Collection (ATCC), and a HCoV-OC43 clinical isolate, designated Paris, were obtained [1].
  • An indirect immunoperoxidase method was first used to localize mouse mammary tumor virus (MMTV) antigens in paraffin sections of mammary tumors of Paris RIII and CD8F1 mice [2].
  • Paris formosana Hayata (Liliaceae) grown in the mountain areas of Taiwan, has been used as a folk remedy for snake bite, and as an anti-inflammatory or anti-neoplastic agent [3].
  • Beta-thalassemia is being corrected in mice by continous erythropoeitin delivery from engineered muscles cells, and from naked DNA electrotransfer into muscles, as described by Dr JM Heard (Institut Pasteur, Paris, France) [4].
  • Effects of polyphyllin D, a steroidal saponin in Paris polyphylla, in growth inhibition of human breast cancer cells and in xenograft [5].
 

Psychiatry related information on Tbc1d2

  • Future directions of this research were discussed at the 1st International Consultation on Erectile Dysfunction, held in Paris, July 1999 [6].
 

High impact information on Tbc1d2

  • Immunoglobulin-containing eluates, prepared from kidneys of Paris RIII mammary tumor-bearing mice approximately 10 months old, were incubated with frozen sections of mouse mammary tumor and normal lactating mammary gland and examined by immunofluorescence [7].
  • Expressive genomics.Human Gene Expression Mapping, (HUGO ESF), Paris, France, 21-22 December 1998 [8].
  • J3V1 contains an additional deletion of 334 base paris in gag, which restores the correct reading frame for v-raf and results in the expression of a p57 gag-raf fusion protein [9].
  • Nucleotide and deduced amino acid sequences from 311 base paris at the 5' terminus showed no homology with any known protein [10].
  • These findings demonstrate that gp52 has preferential utility as a plasma marker for the presence of mammary tumors in MMTV-infected hybrid (BALB/c x DBA/8 F1), Paris RIII, and C3H/HeJ mice [11].
 

Biological context of Tbc1d2

  • Here we report that the genomes of the wild-type YF virus French viscerotropic virus and its attenuated vaccine derivative, FNV virus from the Institut Pasteur, Paris, (FNV-IP) differ by 77 nucleotides encoding 35 amino acid substitutions [12].
  • During the Third International Conference on Negative Control of Hematopoiesis (Paris, April 1993), a special session was devoted to bone marrow protection [13].
  • This data is consistent with previous studies on stimulation of initiation via phosphorylation of initiation factors by multipotential S6 kinase [Morley, S. J. & Traugh, J. A. (1993) Biochemie (Paris) 95, 985-989] [14].
  • Immunomodulating effects of the hydrolysis products of formosanin C and beta-ecdysone from Paris formosana Hayata [15].
  • "Does understanding the brain need proteomics and does understanding proteomics need brains?"--Second HUPO HBPP Workshop hosted in Paris [16].
 

Anatomical context of Tbc1d2

  • Formosanin C (PF-3, I), a diosgenin glycoside with four sugars isolated from Paris formosana Hayata as main constituent, significantly showed immunomodulating effects on the proliferative response of mouse lymphocytes to concanavalin A (Con A) [15].
  • Mouse heads from embryos of 14 to 24 paris of body somites were placed in medium 199 and photographed [17].
  • A report on the Stem Cell EuroConference, Paris, France, 9-10 December 2004 [18].
  • Caco-2 cells infected with virus at a multiplicity of infection of 0.5 yielded 10(4.6) and 10(4.4) plaque forming units/ml (pfu/ml) with CV Rd and CV Paris respectively, while CV Mb yielded only 10(3) pfu/ml [19].
  • Mice peritoneal macrophages obtained after i.p. injection of a medium containing thioglycollate (Institut Pasteur, Paris) have increased levels of beta glucuronidase and acid phosphatase, when compared with macrophages obtained without previous thioglycollate injection [20].
 

Associations of Tbc1d2 with chemical compounds

  • Lactoperoxidase (LPO) has been covalently coupled to affinity-purified anti-ferritin antibodies with p-benzoquinone by a modified version of the method of Ternynck and Avrameas [Ternynck, T., & Avrameas, S. (1976) Ann. Immunol. (Paris) 127C, 197] [21].
  • We compared AmB-DOC with the formulation obtained by heating the commercial form (Fungizone, Bristol Myers Squibb, Paris, France) for 20 min at 70 degrees C, in the treatment of murine infections [22].
  • PRm, which is cytoplasmic in absence of progesterone, is shifted to the nucleus by the hormone as well as by CsA, but not by FK506 or Rapamycin [I. Jung-Testas, M.-C. Lebeau, E.E. Baulieu. C.R. Acad. Sci. Paris 318 (1995) 873-878] [23].
  • Primary and secondary dapsone resistance of M. leprae in Martinique, Guadeloupe, New Caledonia, Tahiti, Senegal, and Paris between 1980 and 1985 [24].
  • In order to determine that contribution which the cell-wall associated lipids make in the pathogenesis of nocardiosis produced by N. asteroides and mycobacteriosis due to M. fortuitum, separate lipid fractions were obtained using the Anderson extraction technique as modified by Asselineau (Asselineau, J. 1966. The Bacterial Lipids. Hermann, Paris) [25].
 

Analytical, diagnostic and therapeutic context of Tbc1d2

  • The euglobulin portion of the eluates, when fractionated on a Sephadex G-200 column, yielded an IgG fraction which was shown by immunodiffusion to react with Paris RIII mammary tumor extract and with anti-mouse globulin but not with nonneoplastic mouse tissue extracts [7].

References

  1. Human respiratory coronavirus OC43: genetic stability and neuroinvasion. St-Jean, J.R., Jacomy, H., Desforges, M., Vabret, A., Freymuth, F., Talbot, P.J. J. Virol. (2004) [Pubmed]
  2. Immunohistochemical detection of a cross-reacting virus antigen in mouse mammary tumors and human breast carcinomas. Mesa-Tejada, R., Keydar, I., Ramanarayanan, M., Ohno, T., Fenoglio, C., Spiegelman, S. J. Histochem. Cytochem. (1978) [Pubmed]
  3. Formosanin-C, an immunomodulator with antitumor activity. Wu, R.T., Chiang, H.C., Fu, W.C., Chien, K.Y., Chung, Y.M., Horng, L.Y. Int. J. Immunopharmacol. (1990) [Pubmed]
  4. Healthcare, molecular tools and applied genome research. Groves, M. IDrugs : the investigational drugs journal. (2000) [Pubmed]
  5. Effects of polyphyllin D, a steroidal saponin in Paris polyphylla, in growth inhibition of human breast cancer cells and in xenograft. Lee, M.S., Yuet-Wa, J.C., Kong, S.K., Yu, B., Eng-Choon, V.O., Nai-Ching, H.W., Chung-Wai, T.M., Fung, K.P. Cancer Biol. Ther. (2005) [Pubmed]
  6. Penile erectile function: recommendations for future research. Andersson, K.E. Int. J. Impot. Res. (2000) [Pubmed]
  7. Elution of tumor-directed antibody from kidneys of mammary tumor-bearing mice. Slovin, S.F., Bennett, S.J., Pascal, R.R. J. Natl. Cancer Inst. (1977) [Pubmed]
  8. Expressive genomics.Human Gene Expression Mapping, (HUGO ESF), Paris, France, 21-22 December 1998. Fougerousse, F., Vekemans, M. Trends Genet. (1999) [Pubmed]
  9. An altered v-raf is required in addition to v-myc in J3V1 virus for acceleration of murine plasmacytomagenesis. Troppmair, J., Potter, M., Wax, J.S., Rapp, U.R. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  10. 5'-structural analysis of genes encoding polymorphic antigens of chemically induced tumors. Srivastava, P.K., Chen, Y.T., Old, L.J. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  11. Quantitation of viral antigens released into plasma and culture fluids by murine mammary tumor cells. Ritzi, E.M., Smith, B.A., Stolfi, R.L., Martin, D.S. Cancer Res. (1981) [Pubmed]
  12. Comparison of the genomes of the wild-type French viscerotropic strain of yellow fever virus with its vaccine derivative French neurotropic vaccine. Wang, E., Ryman, K.D., Jennings, A.D., Wood, D.J., Taffs, F., Minor, P.D., Sanders, P.G., Barrett, A.D. J. Gen. Virol. (1995) [Pubmed]
  13. Bone marrow protection. Guigon, M., Lemoine, F., Najman, A. Bone Marrow Transplant. (1994) [Pubmed]
  14. Insulin stimulation of phosphorylation of elongation factor 1 (eEF-1) enhances elongation activity. Chang, Y.W., Traugh, J.A. Eur. J. Biochem. (1998) [Pubmed]
  15. Immunomodulating effects of the hydrolysis products of formosanin C and beta-ecdysone from Paris formosana Hayata. Chiang, H.C., Wang, J.J., Wu, R.T. Anticancer Res. (1992) [Pubmed]
  16. "Does understanding the brain need proteomics and does understanding proteomics need brains?"--Second HUPO HBPP Workshop hosted in Paris. Hamacher, M., Klose, J., Rossier, J., Marcus, K., Meyer, H.E. Proteomics (2004) [Pubmed]
  17. Rapid nasal pit formation in mouse embryos stimulated by ATP-containing medium. Smuts, M.S. J. Exp. Zool. (1981) [Pubmed]
  18. A full menu for stem-cell research. Spagnoli, F.M., Brivanlou, A.H. Genome Biol. (2005) [Pubmed]
  19. Comparison of the replication of distinct strains of human coronavirus OC43 in organotypic human colon cells (Caco-2) and mouse intestine. Collins, A.R. Adv. Exp. Med. Biol. (1990) [Pubmed]
  20. Effect of thioglycollate on macrophage lysosomal enzymes. Dy, M., Debray-Sachs, M., Kamoun, P., Hamburger, J. Biomedicine / [publiée pour l'A.A.I.C.I.G.]. (1978) [Pubmed]
  21. Macrophage recognition of immune complexes: development and application of novel cell surface labeling procedures. Petty, H.R., Dereski, W. Biochemistry (1985) [Pubmed]
  22. In-vivo therapeutic efficacy in experimental murine mycoses of a new formulation of deoxycholate-amphotericin B obtained by mild heating. Petit, C., Chéron, M., Joly, V., Rodrigues, J.M., Bolard, J., Gaboriau, F. J. Antimicrob. Chemother. (1998) [Pubmed]
  23. Intracellular distribution of a cytoplasmic progesterone receptor mutant and of immunophilins cyclophilin 40 and FKBP59: effects of cyclosporin A, of various metabolic inhibitors and of several culture conditions. Lebeau, M.C., Jung-Testas, I., Baulieu, E.E. J. Steroid Biochem. Mol. Biol. (1999) [Pubmed]
  24. Primary and secondary dapsone resistance of M. leprae in Martinique, Guadeloupe, New Caledonia, Tahiti, Senegal, and Paris between 1980 and 1985. Guelpa-Lauras, C.C., Cartel, J.L., Constant-Desportes, M., Millan, J., Bobin, P., Guidi, C., Brucker, G., Flageul, B., Guillaume, J.C., Pichet, C. Int. J. Lepr. Other Mycobact. Dis. (1987) [Pubmed]
  25. The role of cell-wall associated lipids in the pathogenesis of lesions in experimental murine nocardiosis vs lesions produced by Mycobacterium fortuitum. Miller-Hardy, D.K., Reynolds, B. Comp. Immunol. Microbiol. Infect. Dis. (1984) [Pubmed]
 
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