Gene Review:
Ptk2 - protein tyrosine kinase 2
Rattus norvegicus
Synonyms:
FADK 1, FAK, FRNK, Fak, Fak1, ...
- Activation of focal adhesion kinase by protein kinase C epsilon in neonatal rat ventricular myocytes. Heidkamp, M.C., Bayer, A.L., Scully, B.T., Eble, D.M., Samarel, A.M. Am. J. Physiol. Heart Circ. Physiol. (2003)
- Neonatal cerebral hypoxia-ischemia: involvement of FAK-dependent pathway. Zalewska, T., Makarewicz, D., Janik, B., Ziemka-Nałecz, M. Int. J. Dev. Neurosci. (2005)
- RhoA/ROCK signaling is critical to FAK activation by cyclic stretch in cardiac myocytes. Torsoni, A.S., Marin, T.M., Velloso, L.A., Franchini, K.G. Am. J. Physiol. Heart Circ. Physiol. (2005)
- Subcellular redistribution of focal adhesion kinase and its related nonkinase in hypertrophic myocardium. Yi, X.P., Wang, X., Gerdes, A.M., Li, F. Hypertension (2003)
- Differential regulation of FAK and PYK2 tyrosine phosphorylation after electroconvulsive shock in the rat brain. Kang, U.G., Jun, S.J., Yoon, S.C., Jeon, S., Park, J.B., Chung, C.K., Juhnn, Y.S., Kim, Y.S. Neurosci. Lett. (2004)
- Regulation of a neuronal form of focal adhesion kinase by anandamide. Derkinderen, P., Toutant, M., Burgaya, F., Le Bert, M., Siciliano, J.C., de Franciscis, V., Gelman, M., Girault, J.A. Science (1996)
- Pyk2 and FAK regulate neurite outgrowth induced by growth factors and integrins. Ivankovic-Dikic, I., Grönroos, E., Blaukat, A., Barth, B.U., Dikic, I. Nat. Cell Biol. (2000)
- Pressure activates colon cancer cell adhesion by inside-out focal adhesion complex and actin cytoskeletal signaling. Thamilselvan, V., Basson, M.D. Gastroenterology (2004)
- Effects of dexmedetomidine on hippocampal focal adhesion kinase tyrosine phosphorylation in physiologic and ischemic conditions. Dahmani, S., Rouelle, D., Gressens, P., Mantz, J. Anesthesiology (2005)
- Requirement for focal adhesion kinase in the early phase of mammary adenocarcinoma lung metastasis formation. van Nimwegen, M.J., Verkoeijen, S., van Buren, L., Burg, D., van de Water, B. Cancer Res. (2005)
- Attenuation of focal adhesion kinase signaling following depletion of agonist-sensitive pools of phosphatidylinositol 4,5-bisphosphate. Linseman, D.A., Sorensen, S.D., Fisher, S.K. J. Neurochem. (1999)
- Focal adhesion kinase (FAK)-dependent regulation of S-phase kinase-associated protein-2 (Skp-2) stability. A novel mechanism regulating smooth muscle cell proliferation. Bond, M., Sala-Newby, G.B., Newby, A.C. J. Biol. Chem. (2004)
- The translocation of focal adhesion kinase in brain synaptosomes is regulated by phosphorylation and actin assembly. Bongiorno-Borbone, L., Onofri, F., Giovedì, S., Ferrari, R., Girault, J.A., Benfenati, F. J. Neurochem. (2002)
- Focal adhesion kinase mediates endothelin-induced cyclin D3 expression in rat cultured astrocytes. Koyama, Y., Yoshioka, Y., Shinde, M., Matsuda, T., Baba, A. J. Neurochem. (2004)
- Nerve growth factor (NGF) induces a rapid and sustained downregulation of the focal adhesion kinase (FAK). Gatti, A. Cell. Mol. Neurobiol. (2004)
- Interactions between two cytoskeleton-associated tyrosine kinases: calcium-dependent tyrosine kinase and focal adhesion tyrosine kinase. Li, X., Dy, R.C., Cance, W.G., Graves, L.M., Earp, H.S. J. Biol. Chem. (1999)
- FAK+ and PYK2/CAKbeta, two related tyrosine kinases highly expressed in the central nervous system: similarities and differences in the expression pattern. Menegon, A., Burgaya, F., Baudot, P., Dunlap, D.D., Girault, J.A., Valtorta, F. Eur. J. Neurosci. (1999)
- An endogenous inhibitor of focal adhesion kinase blocks Rac1/JNK but not Ras/ERK-dependent signaling in vascular smooth muscle cells. Sundberg, L.J., Galante, L.M., Bill, H.M., Mack, C.P., Taylor, J.M. J. Biol. Chem. (2003)
- Regulation of ectoplasmic specialization dynamics in the seminiferous epithelium by focal adhesion-associated proteins in testosterone-suppressed rat testes. Wong, C.H., Xia, W., Lee, N.P., Mruk, D.D., Lee, W.M., Cheng, C.Y. Endocrinology (2005)
- Load-induced focal adhesion kinase activation in the myocardium: role of stretch and contractile activity. Domingos, P.P., Fonseca, P.M., Nadruz, W., Franchini, K.G. Am. J. Physiol. Heart Circ. Physiol. (2002)
- Integrin-mediated cell adhesion promotes tyrosine phosphorylation of p130Cas, a Src homology 3-containing molecule having multiple Src homology 2-binding motifs. Nojima, Y., Morino, N., Mimura, T., Hamasaki, K., Furuya, H., Sakai, R., Sato, T., Tachibana, K., Morimoto, C., Yazaki, Y. J. Biol. Chem. (1995)
- Role of protein-tyrosine phosphatase SHP2 in focal adhesion kinase down-regulation during neutrophil cathepsin G-induced cardiomyocytes anoikis. Rafiq, K., Kolpakov, M.A., Abdelfettah, M., Streblow, D.N., Hassid, A., Dell'Italia, L.J., Sabri, A. J. Biol. Chem. (2006)
- The interaction of activated integrin lymphocyte function-associated antigen 1 with ligand intercellular adhesion molecule 1 induces activation and redistribution of focal adhesion kinase and proline-rich tyrosine kinase 2 in T lymphocytes. Rodríguez-Fernández, J.L., Gómez, M., Luque, A., Hogg, N., Sánchez-Madrid, F., Cabañas, C. Mol. Biol. Cell (1999)
- Cloning of focal adhesion kinase, pp125FAK, from rat brain reveals multiple transcripts with different patterns of expression. Burgaya, F., Girault, J.A. Brain Res. Mol. Brain Res. (1996)
- Reciprocally interacting domains of protein phosphatase 1 and focal adhesion kinase. Bianchi, M., De Lucchini, S., Vietri, M., Villa-Moruzzi, E. Mol. Cell. Biochem. (2005)