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MeSH Review

Genes, erbB-1

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Disease relevance of Genes, erbB-1


High impact information on Genes, erbB-1


Chemical compound and disease context of Genes, erbB-1


Biological context of Genes, erbB-1

  • Because the wa-2 mutation was mapped previously to the vicinity of the EGF/TGF-alpha receptor (EGFR) gene on mouse chromosome 11, we hypothesized that the wa-2 phenotype might result from a defect in either the expression or activity of EGFR, or both [15].
  • Alterations of the epidermal growth factor receptor (EGFR) gene are common in some forms of cancer and the most frequent is a deletion of exons 2-7 [16].
  • The Rous-associated virus 1 env gene, which encodes the envelope gp85 and gp37 glycoproteins, was isolated and inserted in place of the v-erbB oncogene into an avian erythroblastosis virus-based vector, carrying the neo resistance gene substituted for the v-erbA oncogene, to generate the pNEA recombinant vector [17].
  • Our molecular genetic studies have suggested that adult GBM can be divided into two genetic subsets: tumors with p53 tumor suppressor gene mutations and chromosome 17p loss that occur more commonly in younger patients; and tumors with epidermal growth factor receptor (EGFR) gene amplification that occur more commonly in older patients [18].
  • Loss of heterozygosity (LOH) for chromosome arms 9p, 10p, 10q, and 17p and amplification of the epidermal growth factor receptor (EGFR) gene have been identified as frequent genetic changes in malignant astrocytomas [19].

Anatomical context of Genes, erbB-1

  • Correspondence re: S. Shintani et al., Intragenic mutation analysis of the human epidermal growth factor receptor (EGFR) gene in malignant human oral keratinocytes. Cancer Res., 59: 4142-4147, 1999 [20].
  • These results demonstrate the existence of EGF receptors in the prepubertal female rat hypothalamus and suggest that changes in EGFR gene expression and biologically active EGFR protein contributes to the neuroendocrine process underlying the first preovulatory surge of gonadotropins.(ABSTRACT TRUNCATED AT 250 WORDS)[21]
  • All-transretinoic acid (retinoid) had little effect on EGF-R, v-erbB gene expression and the proliferation of PSS fibroblasts [22].

Associations of Genes, erbB-1 with chemical compounds

  • By three criteria--tunicamycin inhibition, lectin binding and metabolic labeling with radioactive sugar precursors--the product of the v-erbB gene appears to be a glycoprotein [23].
  • Expression of the human epidermal growth factor receptor (EGFR) gene is inhibited by ligand-activated thyroid hormone receptor (T3R) [24].
  • In contrast, CEF expressing either the v-myc, v-myb-ets, v-mil, v-sea or v-erbB oncogenes are still sensitive to retinoic acid [25].
  • First, individualizing second-line chemotherapy could optimize its effect; the discovery of dramatic responses and significant improvement in survival in patients with epidermal growth factor receptor (EGFR) gene mutations who are treated with EGFR tyrosine kinase inhibitors may lead to the application of other novel therapeutic approaches [26].
  • Sequencing of the mutant v-erbB gene revealed a single amino acid change of a histidine to an aspartate residue at a position equivalent to amino-acid 826 of the human epidermal growth factor receptor [27].

Gene context of Genes, erbB-1


Analytical, diagnostic and therapeutic context of Genes, erbB-1


  1. Amplified and rearranged epidermal growth factor receptor genes in human glioblastomas reveal deletions of sequences encoding portions of the N- and/or C-terminal tails. Ekstrand, A.J., Sugawa, N., James, C.D., Collins, V.P. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  2. Anti-oncogenic activity of signalling-defective epidermal growth factor receptor mutants. Redemann, N., Holzmann, B., von Rüden, T., Wagner, E.F., Schlessinger, J., Ullrich, A. Mol. Cell. Biol. (1992) [Pubmed]
  3. An alternative inhibitor overcomes resistance caused by a mutation of the epidermal growth factor receptor. Kobayashi, S., Ji, H., Yuza, Y., Meyerson, M., Wong, K.K., Tenen, D.G., Halmos, B. Cancer Res. (2005) [Pubmed]
  4. Amplification and expression of the epidermal growth factor receptor gene in human glioma xenografts. Humphrey, P.A., Wong, A.J., Vogelstein, B., Friedman, H.S., Werner, M.H., Bigner, D.D., Bigner, S.H. Cancer Res. (1988) [Pubmed]
  5. Transforming growth factor-alpha production and autoinduction in a colorectal carcinoma cell line (DiFi) with an amplified epidermal growth factor receptor gene. Untawale, S., Zorbas, M.A., Hodgson, C.P., Coffey, R.J., Gallick, G.E., North, S.M., Wildrick, D.M., Olive, M., Blick, M., Yeoman, L.C. Cancer Res. (1993) [Pubmed]
  6. Overexpression of the human EGF receptor confers an EGF-dependent transformed phenotype to NIH 3T3 cells. Di Fiore, P.P., Pierce, J.H., Fleming, T.P., Hazan, R., Ullrich, A., King, C.R., Schlessinger, J., Aaronson, S.A. Cell (1987) [Pubmed]
  7. Protein phosphorylation at tyrosine is induced by the v-erbB gene product in vivo and in vitro. Gilmore, T., DeClue, J.E., Martin, G.S. Cell (1985) [Pubmed]
  8. Temperature-sensitive mutants of avian erythroblastosis virus: surface expression of the erbB product correlates with transformation. Beug, H., Hayman, M.J. Cell (1984) [Pubmed]
  9. A constitutively active epidermal growth factor receptor cooperates with disruption of G1 cell-cycle arrest pathways to induce glioma-like lesions in mice. Holland, E.C., Hively, W.P., DePinho, R.A., Varmus, H.E. Genes Dev. (1998) [Pubmed]
  10. Differences in sequences encoding the carboxyl-terminal domain of the epidermal growth factor receptor correlate with differences in the disease potential of viral erbB genes. Gamett, D.C., Tracy, S.E., Robinson, H.L. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  11. The relationship between epidermal growth factor receptor mutations and clinicopathologic features in non-small cell lung cancers. Tokumo, M., Toyooka, S., Kiura, K., Shigematsu, H., Tomii, K., Aoe, M., Ichimura, K., Tsuda, T., Yano, M., Tsukuda, K., Tabata, M., Ueoka, H., Tanimoto, M., Date, H., Gazdar, A.F., Shimizu, N. Clin. Cancer Res. (2005) [Pubmed]
  12. Mutations within the tyrosine kinase domain of EGFR gene specifically occur in lung adenocarcinoma patients with a low exposure of tobacco smoking. Sugio, K., Uramoto, H., Ono, K., Oyama, T., Hanagiri, T., Sugaya, M., Ichiki, Y., So, T., Nakata, S., Morita, M., Yasumoto, K. Br. J. Cancer (2006) [Pubmed]
  13. Hydroxyurea accelerates the loss of epidermal growth factor receptor genes amplified as double-minute chromosomes in human glioblastoma multiforme. Canute, G.W., Longo, S.L., Longo, J.A., Winfield, J.A., Nevaldine, B.H., Hahn, P.J. Neurosurgery (1996) [Pubmed]
  14. Response to gefitinib in bronchioloalveolar carcinoma in the absence of EGFR mutation. Taja-Chayeb, L., Candelaria, M., Brom, R., Trejo-Becerril, C., Meza, F., Duenas-Gonzalez, A. Lung Cancer (2005) [Pubmed]
  15. The mouse waved-2 phenotype results from a point mutation in the EGF receptor tyrosine kinase. Luetteke, N.C., Phillips, H.K., Qiu, T.H., Copeland, N.G., Earp, H.S., Jenkins, N.A., Lee, D.C. Genes Dev. (1994) [Pubmed]
  16. Mutant epidermal growth factor receptor signaling down-regulates p27 through activation of the phosphatidylinositol 3-kinase/Akt pathway in glioblastomas. Narita, Y., Nagane, M., Mishima, K., Huang, H.J., Furnari, F.B., Cavenee, W.K. Cancer Res. (2002) [Pubmed]
  17. Immune response and resistance to Rous sarcoma virus challenge of chickens immunized with cell-associated glycoproteins provided with a recombinant avian leukosis virus. Chebloune, Y., Rulka, J., Cosset, F.L., Valsesia, S., Ronfort, C., Legras, C., Drynda, A., Kuzmak, J., Nigon, V.M., Verdier, G. J. Virol. (1991) [Pubmed]
  18. Molecular genetics of pediatric brain stem gliomas. Application of PCR techniques to small and archival brain tumor specimens. Louis, D.N., Rubio, M.P., Correa, K.M., Gusella, J.F., von Deimling, A. J. Neuropathol. Exp. Neurol. (1993) [Pubmed]
  19. Amplification of the anonymous marker D17S67 in malignant astrocytomas. Bijlsma, E.K., Leenstra, S., Westerveld, A., Bosch, D.A., Hulsebos, T.J. Genes Chromosomes Cancer (1994) [Pubmed]
  20. Correspondence re: S. Shintani et al., Intragenic mutation analysis of the human epidermal growth factor receptor (EGFR) gene in malignant human oral keratinocytes. Cancer Res., 59: 4142-4147, 1999. Reiter, J.L., Eley, G., James, C.D., Maihle, N.J. Cancer Res. (2000) [Pubmed]
  21. Expression of epidermal growth factor receptor changes in the hypothalamus during the onset of female puberty. Ma, Y.J., Hill, D.F., Junier, M.P., Costa, M.E., Felder, S.E., Ojeda, S.R. Mol. Cell. Neurosci. (1994) [Pubmed]
  22. Epidermal growth factor receptor of fibroblasts from patients with scleroderma. Tokiyama, K., Yokota, E., Niho, Y. J. Rheumatol. (1990) [Pubmed]
  23. The product of the avian erythroblastosis virus erbB locus is a glycoprotein. Privalsky, M.L., Sealy, L., Bishop, J.M., McGrath, J.P., Levinson, A.D. Cell (1983) [Pubmed]
  24. T3 receptor suppression of Sp1-dependent transcription from the epidermal growth factor receptor promoter via overlapping DNA-binding sites. Xu, J., Thompson, K.L., Shephard, L.B., Hudson, L.G., Gill, G.N. J. Biol. Chem. (1993) [Pubmed]
  25. v-erbA oncogene abrogates growth inhibition of chicken embryo fibroblasts induced by retinoic acid. Desbois, C., Pain, B., Guilhot, C., Benchaibi, M., Ffrench, M., Ghysdael, J., Madjar, J.J., Samarut, J. Oncogene (1991) [Pubmed]
  26. Future directions in the second-line treatment of non-small cell lung cancer. Rosell, R., Cecere, F., Cognetti, F., Cuello, M., Sanchez, J.M., Taron, M., Reguart, N., Jablons, D. Semin. Oncol. (2006) [Pubmed]
  27. Common site of mutation in the erbB gene of avian erythroblastosis virus mutants that are temperature sensitive for transformation. Scotting, P., Vennstrom, B., Jansen, M., Graf, T., Beug, H., Hayman, M.J. Oncogene Res. (1987) [Pubmed]
  28. Genetic analyses for predictors of radiation response in glioblastoma. Shih, H.A., Betensky, R.A., Dorfman, M.V., Louis, D.N., Loeffler, J.S., Batchelor, T.T. Int. J. Radiat. Oncol. Biol. Phys. (2005) [Pubmed]
  29. Stepwise transformation of astrocytes by simian virus 40 large T antigen and epidermal growth factor receptor overexpression. Frisa, P.S., Walter, E.I., Ling, L., Kung, H.J., Jacobberger, J.W. Cell Growth Differ. (1996) [Pubmed]
  30. Amplification and overexpression of the cyclin D1 and epidermal growth factor receptor genes in non-small-cell lung cancer. Lung Cancer Study Group. Reissmann, P.T., Koga, H., Figlin, R.A., Holmes, E.C., Slamon, D.J. J. Cancer Res. Clin. Oncol. (1999) [Pubmed]
  31. Transformation by the v-fms oncogene product: an analog of the CSF-1 receptor. Rettenmier, C.W., Jackowski, S., Rock, C.O., Roussel, M.F., Sherr, C.J. J. Cell. Biochem. (1987) [Pubmed]
  32. Vascular endothelial growth factor gene polymorphism is associated with calcium oxalate stone disease. Chen, W.C., Chen, H.Y., Wu, H.C., Wu, M.C., Hsu, C.D., Tsai, F.J. Urol. Res. (2003) [Pubmed]
  33. Analysis of gene amplification in archival tissue by differential polymerase chain reaction. Neubauer, A., Neubauer, B., He, M., Effert, P., Iglehart, D., Frye, R.A., Liu, E. Oncogene (1992) [Pubmed]
  34. Cellular antitumor immune response to a branched lysine multiple antigenic peptide containing epitopes of a common tumor-specific antigen in a rat glioma model. Ciesielski, M.J., Kazim, A.L., Barth, R.F., Fenstermaker, R.A. Cancer Immunol. Immunother. (2005) [Pubmed]
  35. Rapid colorimetric detection of epidermal growth factor receptor mRNA by in situ hybridization. Iezzoni, J.C., Kang, J.H., Bucana, C.D., Reed, J.A., Brigati, D.J. J. Clin. Lab. Anal. (1993) [Pubmed]
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