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Gene Review

FETUIN  -  FETUIN protein

Sus scrofa

Synonyms: AHSG, FETUA
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Disease relevance of FETUIN

  • The endo-alpha-N-acetylgalactosaminidase from the culture medium of Streptomyces sp. OH-11242 (endo-GalNAc-ase-S) hydrolyzed the O-glycosidic linkage between GalNAc and Ser (Thr) in fetuin, liberating oligosaccharides [1].
  • The purified lectin was specific for both T-antigen and N-acetyl-D-lactosamine, markers for various carcinomas, in addition to N-acetyl-D-galactosamine, asialofetuin and fetuin [2].
  • The influence of cultivation medium on fetuin binding by Lactobacillus fermentum L 670 was also not significant while Lactobacillus casei subsp. pseudoplantarum L.c. bound fetuin significantly better (P < 0.01) after growth on Rogosa agar [3].

High impact information on FETUIN

  • In all cases, the binding was inhibited by glycoproteins such as fetuin and thyroglobulin, by a glycopeptide isolated from fetuin, and by some bacterial lipopolysaccharides [4].
  • Infection of swine testicular cells with group C AmC-1 virus was also prevented by glycophorin A, fetuin, and neuraminidase treatment, suggesting that sialic acid constitutes an essential part of the cell receptor [5].
  • Neuraminidase treatment of fresh human erythrocytes or blocking with glycophorin A or fetuin prevented hemagglutination [5].
  • The acrylamide copolymers containing approximately 40 units of Gal beta 1,3GlcNAc beta-, Gal beta 1,3(6-sulfo)GlcNAc beta-, or fetuin triantennary asialo or bovine IgG diantennary glycopeptides were respectively 5.9-, 5.4-, 0.7-, and 0.1-fold as active [6].
  • Although the proportion of Con A-reactive variants of fetuin and AT changes during fetal development, the predominant microform was always that with intermediate affinity against Con A [7].

Biological context of FETUIN


Anatomical context of FETUIN

  • Taking the similarities of human and monkey or pig stomachs into consideration, these results suggest that the primary target cell of H. pylori in colonization in human stomachs is the antral epithelial cell and that the putative adhesin involved in adhesion has affinity for fetuin [12].
  • HoloRBP, but not fetuin or apoRBP, decreased (p < 0.05) TBARS production in all but Day 30 endometrial membranes [13].
  • At postnatal day 28 no alpha 2HS-positive cells or fibres could be found in the neocortex. alpha 2HS has been reported to be very closely related to fetuin which is a fetal plasma protein found in cells of the developing cortex in the sheep and the pig [14].
  • In extracts from fetuses up to 32 days of gestation, the major serum proteins were fetuin, alpha-fetoprotein and alpha 1-antitrypsin, but albumin was not detected [15].
  • PDC-109 competed effectively with zona pellucida glycoproteins for AWN binding, whereas fetuin was a poor competitor [16].

Associations of FETUIN with chemical compounds


Other interactions of FETUIN

  • The concentration of all proteins rose with age until 40-50 days of gestation; and then the serum concentration of alpha-fetoprotein (2.9 mg ml-1), alpha 1-antitrypsin (4.4 mg ml-1) and transferrin (2.6 mg ml-1) fell progressively to about 1 mg ml-1 at birth, whereas those of fetuin, albumin and alpha 1-acid glycoprotein increased [15].
  • In our experiments the enzyme did not hydrolyse the (alpha - 2.6) or (alpha - 2.8) bonds of submaxillary pig mucin and colominic acid, respectively, but it hydrolysed such substrates as fetuin, ovomucin, orosomucoid and horse serum glycoproteins [21].
  • Transferrin and fetuin were the major proteins in amniotic fluid during the second trimester of gestation and together with AFP and albumin accounted for the majority of the total protein in amniotic, but not allantoic fluid [22].

Analytical, diagnostic and therapeutic context of FETUIN


  1. Structural determination of the O-linked sialyl oligosaccharides liberated from fetuin with endo-alpha-N-acetylgalactosaminidase-S by HPLC analysis and 600-MHz 1H-NMR spectroscopy. Ishii-Karakasa, I., Iwase, H., Hotta, K. Eur. J. Biochem. (1997) [Pubmed]
  2. A Novel Antiproliferative and Antifungal Lectin from Amaranthus viridis Linn Seeds. Kaur, N., Dhuna, V., Kamboj, S.S., Agrewala, J.N., Singh, J. Protein Pept. Lett. (2006) [Pubmed]
  3. Lectin-like binding of lactobacilli considered for their use in probiotical preparations for animal use. Styriak, I., Nemcová, R. Berl. Munch. Tierarztl. Wochenschr. (2003) [Pubmed]
  4. Antibodies reactive with cell surface carbohydrates. Sela, B.A., Wang, J.L., Edelman, G.M. Proc. Natl. Acad. Sci. U.S.A. (1975) [Pubmed]
  5. Group C rotavirus requires sialic acid for erythrocyte and cell receptor binding. Svensson, L. J. Virol. (1992) [Pubmed]
  6. Selectin ligands and tumor-associated carbohydrate structures: specificities of alpha 2,3-sialyltransferases in the assembly of 3'-sialyl-6-sialyl/sulfo Lewis a and x, 3'-sialyl-6'-sulfo Lewis x, and 3'-sialyl-6-sialyl/sulfo blood group T-hapten. Chandrasekaran, E.V., Jain, R.K., Larsen, R.D., Wlasichuk, K., Matta, K.L. Biochemistry (1995) [Pubmed]
  7. Concanavalin A crossed affinoimmunoelectrophoretic analysis of the major pig serum proteins during fetal development. Lampreave, F., Alava, M.A., Piñeiro, A. Electrophoresis (1993) [Pubmed]
  8. The nucleotide and deduced amino acid structures of sheep and pig fetuin. Common structural features of the mammalian fetuin family. Brown, W.M., Dziegielewska, K.M., Saunders, N.R., Christie, D.L., Nawratil, P., Müller-Esterl, W. Eur. J. Biochem. (1992) [Pubmed]
  9. Inhibition of sperm motility by bovine serum components. Berger, T., Beierle, J.W. Biol. Reprod. (1990) [Pubmed]
  10. An immunocytochemical study of the distribution of some plasma proteins within the developing forebrain of the pig with special reference to the neocortex. Cavanagh, M.E., Møllgård, K. Brain Res. (1985) [Pubmed]
  11. Porcine zona pellucida ZP3 alpha glycoprotein mediates binding of the biotin-labeled M(r) 55,000 family (ZP3) to boar sperm membrane vesicles. Yurewicz, E.C., Pack, B.A., Armant, D.R., Sacco, A.G. Mol. Reprod. Dev. (1993) [Pubmed]
  12. Adhesion of Helicobacter pylori to gastric epithelial cells in primary cultures obtained from stomachs of various animals. Kobayashi, Y., Okazaki, K., Murakami, K. Infect. Immun. (1993) [Pubmed]
  13. Uteroferrin induces lipid peroxidation in endometrial and conceptus microsomal membranes and is inhibited by apotransferrin, retinol binding protein, and the uteroferrin-associated proteins. Vallet, J.L. Biol. Reprod. (1995) [Pubmed]
  14. An immunocytochemical demonstration of alpha 2HS-glycoprotein in the developing neocortex of the rat. Sarantis, M.E., Saunders, N.R. Neurosci. Lett. (1986) [Pubmed]
  15. Concentrations of major plasma proteins in serum and whole-tissue extracts of porcine fetuses during development. Lampreave, F., Piñeiro, A. J. Reprod. Fertil. (1992) [Pubmed]
  16. Boar spermadhesin AWN-1. Oligosaccharide and zona pellucida binding characteristics. Dostálová, Z., Calvete, J.J., Sanz, L., Töpfer-Petersen, E. Eur. J. Biochem. (1995) [Pubmed]
  17. Biosynthesis of the carbohydrate units of immunoglobulins. 1. Purification and properties of galactosyltransferases from swine mesentary lymph nodes. Rao, A.K., Garver, F., Mendicino, J. Biochemistry (1976) [Pubmed]
  18. Early cortical plate specific glycoprotein in a marsupial species belongs to the same family as fetuin and alpha 2HS glycoprotein. Jones, S.E., Dziegielewska, K.M., Saunders, N.R., Christie, D.L., Sueiras-Diaz, J., Szelke, M. FEBS Lett. (1988) [Pubmed]
  19. Participation of serum and membrane lectins on the oxidative burst regulation in Macrobrachium rosenbergii hemocytes. Sierra, C., Lascurain, R., Pereyra, A., Guevara, J., Martínez, G., Agundis, C., Zenteno, E., Vázquez, L. Dev. Comp. Immunol. (2005) [Pubmed]
  20. Characterization of the attachment of Treponema hyodysenteriae to Henle intestinal epithelial cells in vitro. Bowden, C.A., Joens, L.A., Kelley, L.M. Am. J. Vet. Res. (1989) [Pubmed]
  21. Purification and characterization of some enzymatic properties of neuraminidase from Corynebacterium ulcerans. Vertiev, Y.V., Ezepchuk, Y.V. Hoppe-Seyler's Z. Physiol. Chem. (1981) [Pubmed]
  22. Proteins in the amniotic and allantoic fluids of fetal pigs. McKenna, P. Comp. Biochem. Physiol., B (1984) [Pubmed]
  23. Protein analysis using enzymes immobilized to paramagnetic beads. Krogh, T.N., Berg, T., Højrup, P. Anal. Biochem. (1999) [Pubmed]
  24. Immunological studies on ovine fetuin: radioimmunoassay and comparison with related antigens. Coste, J., Bali, J.P., Aliau, S., Marti, J. Int. J. Biochem. (1980) [Pubmed]
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