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Gene Review

ADM  -  adrenomedullin

Canis lupus familiaris

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Disease relevance of ADM


High impact information on ADM


Biological context of ADM


Anatomical context of ADM


Associations of ADM with chemical compounds

  • In separate experiments, incubation of rings with ADM (10(-8) M) and 3-isobutyl-1-methyl-xanthine (10(-4) M) for 3 min did not significantly affect the accumulation of cyclic guanosine monophosphate (cGMP) and cyclic adenosine monophosphate (cAMP) [10].
  • Relaxations to ADM in rings with endothelium were significantly inhibited only by methylene blue and HS-142-1 [10].
  • Responses to ADM were attenuated during inhibition of nitric oxide (NO) synthesis by nitro-L-arginine (50 [11].
  • ADM was administered intrarenally (1, 5 and 25 ng x kg(-1) x min(-1)) with and without prostaglandin inhibition (meclofenamate, 5 mg/kg intravenous bolus) in anesthetized normal mongrel dogs (n = 5, each) [3].
  • The renal vasodilatation induced by ADM was attenuated by meclofenamate, as well as by renal denervation, although not significantly [3].

Other interactions of ADM


Analytical, diagnostic and therapeutic context of ADM


  1. Autocrine role for the endothelin-B receptor in the secretion of adrenomedullin. Jougasaki, M., Schirger, J.A., Simari, R.D., Burnett, J.C. Hypertension (1998) [Pubmed]
  2. Regulation of cardiac adrenomedullin in heart failure. Jougasaki, M., Grantham, J.A., Redfield, M.M., Burnett, J.C. Peptides (2001) [Pubmed]
  3. Role of prostaglandins and renal nerves in the renal actions of adrenomedullin. Jougasaki, M., Aarhus, L.L., Heublein, D.M., Sandberg, S.M., Burnett, J.C. Am. J. Physiol. (1997) [Pubmed]
  4. Plasma concentration of adrenomedullin is increased in hemorrhagic shock in dogs. Fujioka, S., Ono, Y., Kangawa, K., Okada, K. Anesth. Analg. (1999) [Pubmed]
  5. Regulation of insulin secretion and blood glucose metabolism by adrenomedullin. Martínez, A., Weaver, C., López, J., Bhathena, S.J., Elsasser, T.H., Miller, M.J., Moody, T.W., Unsworth, E.J., Cuttitta, F. Endocrinology (1996) [Pubmed]
  6. Effects of adrenomedullin on load and myocardial performance in normal and heart-failure dogs. Lainchbury, J.G., Meyer, D.M., Jougasaki, M., Burnett, J.C., Redfield, M.M. Am. J. Physiol. Heart Circ. Physiol. (2000) [Pubmed]
  7. cDNA cloning of canine adrenomedullin and its gene expression in the heart and blood vessels in endotoxin shock. Ono, Y., Kojima, M., Okada, K., Kangawa, K. Shock (1998) [Pubmed]
  8. Attenuated natriuretic response to adrenomedullin in experimental heart failure. Jougasaki, M., Heublein, D.M., Sandberg, S.M., Burnett, J.C. J. Card. Fail. (2001) [Pubmed]
  9. Immunohistochemical localization of adrenomedullin in canine heart and aorta. Jougasaki, M., Wei, C.M., Heublein, D.M., Sandberg, S.M., Burnett, J.C. Peptides (1995) [Pubmed]
  10. Adrenomedullin-mediated relaxations in veins are endothelium-dependent and distinct from arteries. Barber, D.A., Park, Y.S., Burnett, J.C., Miller, V.M. J. Cardiovasc. Pharmacol. (1997) [Pubmed]
  11. Renal responses to intra-arterial administration of adrenomedullin in dogs. Majid, D.S., Kadowitz, P.J., Coy, D.H., Navar, L.G. Am. J. Physiol. (1996) [Pubmed]
  12. Differential actions of vasopeptidase inhibition versus angiotensin-converting enzyme inhibition on diuretic therapy in experimental congestive heart failure. Cataliotti, A., Boerrigter, G., Chen, H.H., Jougasaki, M., Costello, L.C., Tsuruda, T., Lee, S.C., Malatino, L.S., Burnett, J.C. Circulation (2002) [Pubmed]
  13. Inhibition by adrenomedullin of amine release from adrenergic nerves in dog mesenteric arteries. Fujioka, H., Okamura, T., Toda, N. Eur. J. Pharmacol. (1999) [Pubmed]
  14. Function of the vascular endothelium after hypothermic storage at four degrees Celsius in a canine tibial perfusion model. The role of adrenomedullin in reperfusion injury. Kato, T., Bishop, A.T., Tu, Y.K., Wood, M.B. The Journal of bone and joint surgery. American volume. (1998) [Pubmed]
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