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Gene Review

CD44  -  CD44 molecule (Indian blood group)

Canis lupus familiaris

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Disease relevance of CD44


High impact information on CD44


Biological context of CD44

  • Using PCR with primers complementary to regions contiguous to the insertion point and a variant exon, all ten variant exons of dog CD44 were detected in a high number of different isoforms [7].
  • CD44, the main cell surface receptor for hyaluronan (HA), is often overexpressed in tumour cells, and its presence has been related to cell proliferation and migration [2].
  • Two of the proteins identified, CD44 and E-selectin, are known to be involved in cell adhesion and cancer cell migration [3].

Anatomical context of CD44


Associations of CD44 with chemical compounds


Analytical, diagnostic and therapeutic context of CD44


  1. Organ-specific immunity in canine visceral leishmaniasis: analysis of symptomatic and asymptomatic dogs naturally infected with Leishmania chagasi. Sanchez, M.A., Diaz, N.L., Zerpa, O., Negron, E., Convit, J., Tapia, F.J. Am. J. Trop. Med. Hyg. (2004) [Pubmed]
  2. Differential expression of CD44 in canine melanocytic tumours. Serra, M., Rabanal, R.M., Miquel, L., Domenzain, C., Bassols, A. J. Comp. Pathol. (2004) [Pubmed]
  3. Comparative proteomics of glycoproteins based on lectin selection and isotope coding. Xiong, L., Andrews, D., Regnier, F. J. Proteome Res. (2003) [Pubmed]
  4. Up-regulation of the hyaluronate receptor CD44 in canine distemper demyelinated plaques. Alldinger, S., Fonfara, S., Kremmer, E., Baumgärtner, W. Acta Neuropathol. (2000) [Pubmed]
  5. The NF2 tumor suppressor gene product, merlin, mediates contact inhibition of growth through interactions with CD44. Morrison, H., Sherman, L.S., Legg, J., Banine, F., Isacke, C., Haipek, C.A., Gutmann, D.H., Ponta, H., Herrlich, P. Genes Dev. (2001) [Pubmed]
  6. An antibody to CD44 enhances hematopoiesis in long-term marrow cultures. Rossbach, H.C., Krizanac-Bengez, L., Santos, E.B., Gooley, T.A., Sandmaier, B.M. Exp. Hematol. (1996) [Pubmed]
  7. Expression of CD44 variant transcripts in dog lymphatic tissue. Milde, K.F., Alejandro, R., Pastori, R.L. Immunogenetics (1994) [Pubmed]
  8. Characterization of canine microglial cells isolated ex vivo. Stein, V.M., Czub, M., Hansen, R., Leibold, W., Moore, P.F., Zurbriggen, A., Tipold, A. Vet. Immunol. Immunopathol. (2004) [Pubmed]
  9. Pericellular matrix formation by renal tubule epithelial cells in relation to crystal binding. Schepers, M.S., Asselman, M., Duim, R.A., Romijn, J.C., Schröder, F.H., Verkoelen, C.F. Nephron Exp. Nephrol. (2003) [Pubmed]
  10. Molecular cloning of the canine CD44 antigen cDNA. Milde, K.F., Alejandro, R., Mintz, D.H., Pastori, R.L. Biochim. Biophys. Acta (1994) [Pubmed]
  11. Markers of airway smooth muscle cell phenotype. Halayko, A.J., Salari, H., MA, X., Stephens, N.L. Am. J. Physiol. (1996) [Pubmed]
  12. Roles of an extracellular matrix (ECM) receptor and ECM processing enzymes in demyelinating canine distemper encephalitis. Alldinger, S., Gröters, S., Miao, Q., Fonfara, S., Kremmer, E., Baumgärtner, W. DTW. Dtsch. Tierarztl. Wochenschr. (2006) [Pubmed]
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