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Gene Review

CD207  -  CD207 molecule, langerin

Homo sapiens

Synonyms: C-type lectin domain family 4 member K, CLEC4K, Langerin
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Disease relevance of CD207


High impact information on CD207

  • We have identified a type II Ca2+-dependent lectin displaying mannose-binding specificity, exclusively expressed by Langerhans cells (LC), and named Langerin [4].
  • Remarkably, transfection of Langerin cDNA into fibroblasts created a compact network of membrane structures with typical features of BG [4].
  • Our data suggest that induction of BG is a consequence of the antigen-capture function of Langerin, allowing routing into these organelles and providing access to a nonclassical antigen-processing pathway [4].
  • These immediate precursors expressed CD14, langerin and functional CCR6 [5].
  • Langerhans cells utilize CD1a and langerin to efficiently present nonpeptide antigens to T cells [1].

Biological context of CD207


Anatomical context of CD207


Associations of CD207 with chemical compounds

  • However, Langerin did bind to surfaces of primary skin fibroblasts and NIH3T3 cells. "Ligand blotting" of fibroblast membrane-enriched fractions with Langerin revealed reproducible binding to 140 and 240 kDa proteins resolved in reduced denaturing gels [13].
  • The results are consistent with a role for langerin in internalization of both self and nonself glycoprotein antigens [14].
  • In contrast, LC uptake was inhibited only by filipin, and VLP in LC were associated with caveolin, langerin, and CD1a [15].
  • Unlike two C-type lectins of leukocytes, L-selectin and Langerin, which also bind to sulphated analogues of sialyl-Le(x), the siglecs do not give detectable binding signals with sulphated analogues that are lacking sialic acid [16].

Regulatory relationships of CD207


Other interactions of CD207


Analytical, diagnostic and therapeutic context of CD207

  • As opposed to the uniform absence of donor LC at the time of transplantation, examination of the epidermis from the grafts after 2-4 weeks revealed MHC class II(+) donor cells, which had acquired CD205 and CD207, thus qualifying them as LC [6].
  • We have recently combined high resolution two-photon immunofluorescence (using anti MHC-II and Langerin/CD207 antibodies) imaging with microspectroscopy and advanced image-processing/volume-rendering modalities [21].
  • Recombinant soluble Langerin did not bind to lymph node or spleen cells, or keratinocytes as assessed via flow cytometry [13].
  • In this study, analytical ultracentrifugation and circular dichroism spectroscopy of recombinant soluble fragments of human langerin have been used to show that the extracellular region of this receptor exists as a stable trimer held together by a coiled coil of alpha-helices formed by the neck region [14].
  • These results provide evidence for the usefulness of Langerin-directed immuno- and glycohistochemical monitoring of bronchoalveolar lavage fluid in the diagnosis of pulmonary Langerhans cell histiocytosis [22].


  1. Langerhans cells utilize CD1a and langerin to efficiently present nonpeptide antigens to T cells. Hunger, R.E., Sieling, P.A., Ochoa, M.T., Sugaya, M., Burdick, A.E., Rea, T.H., Brennan, P.J., Belisle, J.T., Blauvelt, A., Porcelli, S.A., Modlin, R.L. J. Clin. Invest. (2004) [Pubmed]
  2. Human papillomavirus 16 virus-like particles use heparan sulfates to bind dendritic cells and colocalize with langerin in Langerhans cells. Bousarghin, L., Hubert, P., Franzen, E., Jacobs, N., Boniver, J., Delvenne, P. J. Gen. Virol. (2005) [Pubmed]
  3. Comparison of the expression of Langerin and 175 kD mannose receptor in antigen-presenting cells in normal human skin and basal cell carcinoma. Plzáková, Z., Chovanec, M., Smetana, K., Plzák, J., Stork, J., Saeland, S. Folia Biol. (Praha) (2004) [Pubmed]
  4. Langerin, a novel C-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granules. Valladeau, J., Ravel, O., Dezutter-Dambuyant, C., Moore, K., Kleijmeer, M., Liu, Y., Duvert-Frances, V., Vincent, C., Schmitt, D., Davoust, J., Caux, C., Lebecque, S., Saeland, S. Immunity (2000) [Pubmed]
  5. Dermal-resident CD14+ cells differentiate into Langerhans cells. Larregina, A.T., Morelli, A.E., Spencer, L.A., Logar, A.J., Watkins, S.C., Thomson, A.W., Falo, L.D. Nat. Immunol. (2001) [Pubmed]
  6. Fetal and neonatal murine skin harbors Langerhans cell precursors. Chang-Rodriguez, S., Hoetzenecker, W., Schwärzler, C., Biedermann, T., Saeland, S., Elbe-Bürger, A. J. Leukoc. Biol. (2005) [Pubmed]
  7. Large-scale isolation of immature dendritic cells with features of Langerhans cells by sorting CD34+ cord blood stem cells cultured in the presence of TGF-beta1 for cutaneous leukocyte antigen (CLA). Bartz, H., Rothoeft, T., Anhenn, O., Bunse, D., Schauer, U. J. Immunol. Methods (2003) [Pubmed]
  8. A lack of Birbeck granules in Langerhans cells is associated with a naturally occurring point mutation in the human Langerin gene. Verdijk, P., Dijkman, R., Plasmeijer, E.I., Mulder, A.A., Zoutman, W.H., Mieke Mommaas, A., Tensen, C.P. J. Invest. Dermatol. (2005) [Pubmed]
  9. Polymorphisms in human langerin affect stability and sugar binding activity. Ward, E.M., Stambach, N.S., Drickamer, K., Taylor, M.E. J. Biol. Chem. (2006) [Pubmed]
  10. Langerin/CD207 sheds light on formation of birbeck granules and their possible function in Langerhans cells. Valladeau, J., Dezutter-Dambuyant, C., Saeland, S. Immunol. Res. (2003) [Pubmed]
  11. Langerin (CD207) staining in normal pediatric tissues, reactive lymph nodes, and childhood histiocytic disorders. Chikwava, K., Jaffe, R. Pediatr. Dev. Pathol. (2004) [Pubmed]
  12. The role of dendritic cell C-type lectin receptors in HIV pathogenesis. Turville, S., Wilkinson, J., Cameron, P., Dable, J., Cunningham, A.L. J. Leukoc. Biol. (2003) [Pubmed]
  13. Identification and characterization of endogenous Langerin ligands in murine extracellular matrix. Tada, Y., Riedl, E., Lowenthal, M.S., Liotta, L.A., Briner, D.M., Crouch, E.C., Udey, M.C. J. Invest. Dermatol. (2006) [Pubmed]
  14. Characterization of carbohydrate recognition by langerin, a C-type lectin of Langerhans cells. Stambach, N.S., Taylor, M.E. Glycobiology (2003) [Pubmed]
  15. Despite differences between dendritic cells and Langerhans cells in the mechanism of papillomavirus-like particle antigen uptake, both cells cross-prime T cells. Yan, M., Peng, J., Jabbar, I.A., Liu, X., Filgueira, L., Frazer, I.H., Thomas, R. Virology (2004) [Pubmed]
  16. Carbohydrate microarrays reveal sulphation as a modulator of siglec binding. Campanero-Rhodes, M.A., Childs, R.A., Kiso, M., Komba, S., Le Narvor, C., Warren, J., Otto, D., Crocker, P.R., Feizi, T. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  17. Antagonistic effects of IL-4 and TGF-beta1 on Langerhans cell-related antigen expression by human monocytes. Guironnet, G., Dezutter-Dambuyant, C., Vincent, C., Bechetoille, N., Schmitt, D., Péguet-Navarro, J. J. Leukoc. Biol. (2002) [Pubmed]
  18. Differentiation of Langerhans cells in Langerhans cell histiocytosis. Geissmann, F., Lepelletier, Y., Fraitag, S., Valladeau, J., Bodemer, C., Debré, M., Leborgne, M., Saeland, S., Brousse, N. Blood (2001) [Pubmed]
  19. Human BDCA-1-positive blood dendritic cells differentiate into phenotypically distinct immature and mature populations in the absence of exogenous maturational stimuli: differentiation failure in HIV infection. Patterson, S., Donaghy, H., Amjadi, P., Gazzard, B., Gotch, F., Kelleher, P. J. Immunol. (2005) [Pubmed]
  20. Interleukin-3 in cooperation with transforming growth factor beta induces granulocyte macrophage colony stimulating factor independent differentiation of human CD34+ hematopoietic progenitor cells into dendritic cells with features of Langerhans cells. Mollah, Z.U., Aiba, S., Nakagawa, S., Mizuashi, M., Ohtani, T., Yoshino, Y., Tagami, H. J. Invest. Dermatol. (2003) [Pubmed]
  21. Femtosecond two-photon high-resolution 3D imaging, spatial-volume rendering and microspectral characterization of immunolocalized MHC-II and mLangerin/CD207 antigens in the mouse epidermis. Tirlapur, U.K., Mulholland, W.J., Bellhouse, B.J., Kendall, M., Cornhill, J.F., Cui, Z. Microsc. Res. Tech. (2006) [Pubmed]
  22. Diagnostic relevance of Langerin detection in cells from bronchoalveolar lavage of patients with pulmonary Langerhans cell histiocytosis, sarcoidosis and idiopathic pulmonary fibrosis. Smetana, K., Mericka, O., Saeland, S., Homolka, J., Brabec, J., Gabius, H.J. Virchows Arch. (2004) [Pubmed]
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