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Gene Review

MUC8  -  mucin 8

Homo sapiens

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Disease relevance of MUC8


High impact information on MUC8


Biological context of MUC8


Anatomical context of MUC8


Associations of MUC8 with chemical compounds


Regulatory relationships of MUC8

  • MUC5AC and MUC5B mRNA were mainly expressed between the 7th and the 14th day after confluence with relatively weak MUC8 and lysozyme expression [13].

Other interactions of MUC8

  • In contrast, only MUC1 levels increased with no significant changes in expression of MUC5B and MUC8 in cervical tumors over normal cervical tissues [14].
  • TNF-alpha, IL-1beta and a combination of both all significantly increased MUC8 mRNA levels [15].
  • In addition, the expressions of mucin gene 5AC (MUCSAC) and MUC8 mRNAs were suppressed, and the expression of cornifin-alpha mRNA increased progressively as a function of differentiation in RA-deficient cultures [16].

Analytical, diagnostic and therapeutic context of MUC8

  • Northern blot analysis was used to detect MUC8 messenger RNA (mRNA) in male and female reproductive tract tissues [9].
  • MUC8 showed reactivity in 14 out of 15 dacryoliths analyzed by immunohistochemistry [17].
  • MUC8 mRNA and protein levels were determined in NHNE cells treated with IL-1beta (10 ng/ml for 24 h) using reverse transcriptase-PCR and Western blot analysis [11].
  • On Days 2, 7, 14 and 28 after confluence, ciliated cells were counted by means of cytospin slide immunostaining using H6C5 and beta-tubulin, and MUC8 mRNA levels were determined using real-time quantitative polymerase chain reaction (PCR) [11].
  • The MUC5AC and MUC8 mRNA levels were analyzed by RT-PCR [18].


  1. Prostaglandin E2 induces MUC8 gene expression via a mechanism involving ERK MAPK/RSK1/cAMP response element binding protein activation in human airway epithelial cells. Cho, K.N., Choi, J.Y., Kim, C.H., Baek, S.J., Chung, K.C., Moon, U.Y., Kim, K.S., Lee, W.J., Koo, J.S., Yoon, J.H. J. Biol. Chem. (2005) [Pubmed]
  2. Mucins as differentiation markers in bronchial epithelium. Squamous cell carcinoma and adenocarcinoma display similar expression patterns. López-Ferrer, A., Curull, V., Barranco, C., Garrido, M., Lloreta, J., Real, F.X., de Bolós C, n.u.l.l. Am. J. Respir. Cell Mol. Biol. (2001) [Pubmed]
  3. Induction of MUC8 gene expression by interleukin-1 beta is mediated by a sequential ERK MAPK/RSK1/CREB cascade pathway in human airway epithelial cells. Song, K.S., Seong, J.K., Chung, K.C., Lee, W.J., Kim, C.H., Cho, K.N., Kang, C.D., Koo, J.S., Yoon, J.H. J. Biol. Chem. (2003) [Pubmed]
  4. Upregulation of MUC8 and downregulation of MUC5AC by inflammatory mediators in human nasal polyps and cultured nasal epithelium. Seong, J.K., Koo, J.S., Lee, W.J., Kim, H.N., Park, J.Y., Song, K.S., Hong, J.H., Yoon, J.H. Acta Otolaryngol. (2002) [Pubmed]
  5. Differential mucin MUC7 gene expression in invasive bladder carcinoma in contrast to uniform MUC1 and MUC2 gene expression in both normal urothelium and bladder carcinoma. Retz, M., Lehmann, J., Röder, C., Plötz, B., Harder, J., Eggers, J., Pauluschke, J., Kalthoff, H., Stöckle, M. Cancer Res. (1998) [Pubmed]
  6. Developmental expression of mucin genes in the human gastrointestinal system. Reid, C.J., Harris, A. Gut (1998) [Pubmed]
  7. Chromosomal localization of a human mucin gene (MUC8) and cloning of the cDNA corresponding to the carboxy terminus. Shankar, V., Pichan, P., Eddy, R.L., Tonk, V., Nowak, N., Sait, S.N., Shows, T.B., Schultz, R.E., Gotway, G., Elkins, R.C., Gilmore, M.S., Sachdev, G.P. Am. J. Respir. Cell Mol. Biol. (1997) [Pubmed]
  8. MUC8 mucin gene up-regulation in chronic rhinosinusitis. Lee, H.M., Kim, D.H., Kim, J.M., Lee, S.H., Hwang, S.J. The Annals of otology, rhinology, and laryngology. (2004) [Pubmed]
  9. Antigenic cross-reactivity of human tracheal mucin with human sperm and trophoblasts correlates with the expression of mucin 8 gene messenger ribonucleic acid in reproductive tract tissues. D'Cruz, O.J., Dunn, T.S., Pichan, P., Hass, G.G., Sachdev, G.P. Fertil. Steril. (1996) [Pubmed]
  10. Levels of intracellular protein and messenger RNA of mucin and lysozyme in normal human nasal and polyp epithelium. Kim, S.S., Kim, K.S., Lee, J.G., Park, I.Y., Koo, J.S., Yoon, J.H. Laryngoscope (2000) [Pubmed]
  11. MUC8 as a ciliated cell marker in human nasal epithelium. Kim, C.H., Kim, H.J., Song, K.S., Seong, J.K., Kim, K.S., Lee, J.G., Yoon, J.H. Acta Otolaryngol. (2005) [Pubmed]
  12. Effects of dexamethasone on mucin gene expression in cultured human nasal epithelial cells. Ishinaga, H., Takeuchi, K., Kishioka, C., Yagawa, M., Majima, Y. Laryngoscope (2002) [Pubmed]
  13. Mucociliary differentiation according to time in human nasal epithelial cell culture. Yoon, J.H., Moon, H.J., Seong, J.K., Kim, C.H., Lee, J.J., Choi, J.Y., Song, M.S., Kim, S.H. Differentiation (2002) [Pubmed]
  14. Differential expression of MUC genes in endometrial and cervical tissues and tumors. Hebbar, V., Damera, G., Sachdev, G.P. BMC Cancer (2005) [Pubmed]
  15. Effects of TNF-alpha and IL-1 beta on mucin, lysozyme, IL-6 and IL-8 in passage-2 normal human nasal epithelial cells. Yoon, J.H., Kim, K.S., Kim, H.U., Linton, J.A., Lee, J.G. Acta Otolaryngol. (1999) [Pubmed]
  16. Retinoic acid depletion induces keratinizing squamous differentiation in human middle ear epithelial cell cultures. Choi, J.Y., Cho, K.N., Yoo, K.H., Shin, J.H., Yoon, J.H. Acta Otolaryngol. (2003) [Pubmed]
  17. TFF peptides and mucins are major components of dacryoliths. Paulsen, F.P., Schaudig, U., Fabian, A., Ehrich, D., Sel, S. Graefes Arch. Clin. Exp. Ophthalmol. (2006) [Pubmed]
  18. Use of PLGA scaffold for mucociliary epithelium transfer in airway reconstruction: a preliminary study. Kim, C.H., Bae, J.H., Son, S., Kim, J.H., Lee, J.G., Yoon, J.H. Acta Otolaryngol. (2006) [Pubmed]
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