The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Eng  -  endoglin

Mus musculus

Synonyms: AI528660, AI662476, CD105, Cell surface MJ7/18 antigen, Edg, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Eng


High impact information on Eng


Chemical compound and disease context of Eng


Biological context of Eng


Anatomical context of Eng


Associations of Eng with chemical compounds


Physical interactions of Eng


Regulatory relationships of Eng

  • Whereas Eng+/+ cells were only partially growth inhibited by TGFbeta, Eng-/- cells displayed a potent anti-proliferative response [1].
  • Endoglin null endothelial cells proliferate faster and are more responsive to transforming growth factor beta1 with higher affinity receptors and an activated Alk1 pathway [1].
  • Between 7.5 and 8.5 dpc, endoglin was expressed in endothelial cells of the yolk sac, dorsal aorta and primitive heart tube, and from 9.5 to 13.5 dpc in endothelial cells throughout the developing vasculature [17].
  • The objective of the present study was to investigate the role of endoglin expressed on uterine stromal cells in binding TGF-beta and in the cellular responses induced by this growth factor [18].

Other interactions of Eng

  • However, the function of endoglin in TGF-beta/ALK signalling has remained unclear [13].
  • Endoglin is an accessory receptor for transforming growth factor beta (TGFbeta) in endothelial cells, essential for vascular development [1].
  • Tumor weight, capillary density, hemoglobin and VCAM-1 were reduced by about 30% in Eng+/- compared to Eng+/+ littermates [19].
  • Its pivotal role in angiogenesis is underscored in Endoglin null (Eng-/-) murine embryos, which die at mid-gestation (E10.5) from impaired yolk sac vessel formation [1].
  • Pronounced interstitial fibrosis induced by ureteral obstruction was confirmed histologically by Masson's trichromic staining and by increased immunostaining for fibronectin and laminin without significant differences between Eng(+/-) and Eng(+/+) mice [20].

Analytical, diagnostic and therapeutic context of Eng


  1. Endoglin null endothelial cells proliferate faster and are more responsive to transforming growth factor beta1 with higher affinity receptors and an activated Alk1 pathway. Pece-Barbara, N., Vera, S., Kathirkamathamby, K., Liebner, S., Di Guglielmo, G.M., Dejana, E., Wrana, J.L., Letarte, M. J. Biol. Chem. (2005) [Pubmed]
  2. Endoglin regulates renal ischaemia-reperfusion injury. Docherty, N.G., López-Novoa, J.M., Arevalo, M., Düwel, A., Rodriguez-Peña, A., Pérez-Barriocanal, F., Bernabeu, C., Eleno, N. Nephrol. Dial. Transplant. (2006) [Pubmed]
  3. Endoglin expression in hyper-cholesterolemia and after atorvastatin treatment in apoE-deficient mice. Pospisilova, N., Semecky, V., Jamborova, G., Pospechova, K., Solichova, D., Andrys, C., Zdansky, P., Nachtigal, P. Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Soci??t?? canadienne des sciences pharmaceutiques (2006) [Pubmed]
  4. Characterization of murine S-endoglin isoform and its effects on tumor development. Pérez-Gómez, E., Eleno, N., López-Novoa, J.M., Ramirez, J.R., Velasco, B., Letarte, M., Bernabéu, C., Quintanilla, M. Oncogene (2005) [Pubmed]
  5. Soluble endoglin contributes to the pathogenesis of preeclampsia. Venkatesha, S., Toporsian, M., Lam, C., Hanai, J., Mammoto, T., Kim, Y.M., Bdolah, Y., Lim, K.H., Yuan, H.T., Libermann, T.A., Stillman, I.E., Roberts, D., D'Amore, P.A., Epstein, F.H., Sellke, F.W., Romero, R., Sukhatme, V.P., Letarte, M., Karumanchi, S.A. Nat. Med. (2006) [Pubmed]
  6. Defective angiogenesis in mice lacking endoglin. Li, D.Y., Sorensen, L.K., Brooke, B.S., Urness, L.D., Davis, E.C., Taylor, D.G., Boak, B.B., Wendel, D.P. Science (1999) [Pubmed]
  7. The endoglin(positive) sca-1(positive) rhodamine(low) phenotype defines a near-homogeneous population of long-term repopulating hematopoietic stem cells. Chen, C.Z., Li, L., Li, M., Lodish, H.F. Immunity (2003) [Pubmed]
  8. Dual mechanisms for lysophospholipid induction of proliferation of human breast carcinoma cells. Goetzl, E.J., Dolezalova, H., Kong, Y., Zeng, L. Cancer Res. (1999) [Pubmed]
  9. Antiangiogenic therapy of established tumors in human skin/severe combined immunodeficiency mouse chimeras by anti-endoglin (CD105) monoclonal antibodies, and synergy between anti-endoglin antibody and cyclophosphamide. Takahashi, N., Haba, A., Matsuno, F., Seon, B.K. Cancer Res. (2001) [Pubmed]
  10. Phosphorylation of the human-transforming-growth-factor-beta-binding protein endoglin. Lastres, P., Martín-Perez, J., Langa, C., Bernabéu, C. Biochem. J. (1994) [Pubmed]
  11. Endoglin increases eNOS expression by modulating Smad2 protein levels and Smad2-dependent TGF-beta signaling. Santibanez, J.F., Letamendia, A., Perez-Barriocanal, F., Silvestri, C., Saura, M., Vary, C.P., Lopez-Novoa, J.M., Attisano, L., Bernabeu, C. J. Cell. Physiol. (2007) [Pubmed]
  12. Defective paracrine signalling by TGFbeta in yolk sac vasculature of endoglin mutant mice: a paradigm for hereditary haemorrhagic telangiectasia. Carvalho, R.L., Jonker, L., Goumans, M.J., Larsson, J., Bouwman, P., Karlsson, S., Dijke, P.T., Arthur, H.M., Mummery, C.L. Development (2004) [Pubmed]
  13. Endoglin promotes endothelial cell proliferation and TGF-beta/ALK1 signal transduction. Lebrin, F., Goumans, M.J., Jonker, L., Carvalho, R.L., Valdimarsdottir, G., Thorikay, M., Mummery, C., Arthur, H.M., ten Dijke, P. EMBO J. (2004) [Pubmed]
  14. Molecular characterization and in situ localization of murine endoglin reveal that it is a transforming growth factor-beta binding protein of endothelial and stromal cells. St-Jacques, S., Cymerman, U., Pece, N., Letarte, M. Endocrinology (1994) [Pubmed]
  15. Endoglin regulates nitric oxide-dependent vasodilatation. Jerkic, M., Rivas-Elena, J.V., Prieto, M., Carrón, R., Sanz-Rodríguez, F., Pérez-Barriocanal, F., Rodríguez-Barbero, A., Bernabéu, C., López-Novoa, J.M. FASEB J. (2004) [Pubmed]
  16. Identification and expression of two forms of the human transforming growth factor-beta-binding protein endoglin with distinct cytoplasmic regions. Bellón, T., Corbí, A., Lastres, P., Calés, C., Cebrián, M., Vera, S., Cheifetz, S., Massague, J., Letarte, M., Bernabéu, C. Eur. J. Immunol. (1993) [Pubmed]
  17. Endoglin expression in early development is associated with vasculogenesis and angiogenesis. Jonker, L., Arthur, H.M. Mech. Dev. (2002) [Pubmed]
  18. Characterization of endoglin on mouse uterine stromal cells. Ouellette, M.J., Hamel, L., Tremblay, N., Lamothe, M., St-Jacques, S. J. Reprod. Fertil. (1999) [Pubmed]
  19. Reduced tumor growth and angiogenesis in endoglin-haploinsufficient mice. D??wel, A., Eleno, N., Jerkic, M., Arevalo, M., Bola??os, J.P., Bernabeu, C., L??pez-Novoa, J.M. Tumour Biol. (2007) [Pubmed]
  20. Endoglin upregulation during experimental renal interstitial fibrosis in mice. Rodríguez-Peña, A., Eleno, N., Düwell, A., Arévalo, M., Pérez-Barriocanal, F., Flores, O., Docherty, N., Bernabeu, C., Letarte, M., López-Novoa, J.M. Hypertension (2002) [Pubmed]
  21. Endoglin, an ancillary TGFbeta receptor, is required for extraembryonic angiogenesis and plays a key role in heart development. Arthur, H.M., Ure, J., Smith, A.J., Renforth, G., Wilson, D.I., Torsney, E., Charlton, R., Parums, D.V., Jowett, T., Marchuk, D.A., Burn, J., Diamond, A.G. Dev. Biol. (2000) [Pubmed]
WikiGenes - Universities