Gene Review:
Eng - endoglin
Mus musculus
Synonyms:
AI528660, AI662476, CD105, Cell surface MJ7/18 antigen, Edg, ...
- Endoglin null endothelial cells proliferate faster and are more responsive to transforming growth factor beta1 with higher affinity receptors and an activated Alk1 pathway. Pece-Barbara, N., Vera, S., Kathirkamathamby, K., Liebner, S., Di Guglielmo, G.M., Dejana, E., Wrana, J.L., Letarte, M. J. Biol. Chem. (2005)
- Endoglin regulates renal ischaemia-reperfusion injury. Docherty, N.G., López-Novoa, J.M., Arevalo, M., Düwel, A., Rodriguez-Peña, A., Pérez-Barriocanal, F., Bernabeu, C., Eleno, N. Nephrol. Dial. Transplant. (2006)
- Endoglin expression in hyper-cholesterolemia and after atorvastatin treatment in apoE-deficient mice. Pospisilova, N., Semecky, V., Jamborova, G., Pospechova, K., Solichova, D., Andrys, C., Zdansky, P., Nachtigal, P. Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Soci??t?? canadienne des sciences pharmaceutiques (2006)
- Characterization of murine S-endoglin isoform and its effects on tumor development. Pérez-Gómez, E., Eleno, N., López-Novoa, J.M., Ramirez, J.R., Velasco, B., Letarte, M., Bernabéu, C., Quintanilla, M. Oncogene (2005)
- Soluble endoglin contributes to the pathogenesis of preeclampsia. Venkatesha, S., Toporsian, M., Lam, C., Hanai, J., Mammoto, T., Kim, Y.M., Bdolah, Y., Lim, K.H., Yuan, H.T., Libermann, T.A., Stillman, I.E., Roberts, D., D'Amore, P.A., Epstein, F.H., Sellke, F.W., Romero, R., Sukhatme, V.P., Letarte, M., Karumanchi, S.A. Nat. Med. (2006)
- Defective angiogenesis in mice lacking endoglin. Li, D.Y., Sorensen, L.K., Brooke, B.S., Urness, L.D., Davis, E.C., Taylor, D.G., Boak, B.B., Wendel, D.P. Science (1999)
- The endoglin(positive) sca-1(positive) rhodamine(low) phenotype defines a near-homogeneous population of long-term repopulating hematopoietic stem cells. Chen, C.Z., Li, L., Li, M., Lodish, H.F. Immunity (2003)
- Dual mechanisms for lysophospholipid induction of proliferation of human breast carcinoma cells. Goetzl, E.J., Dolezalova, H., Kong, Y., Zeng, L. Cancer Res. (1999)
- Antiangiogenic therapy of established tumors in human skin/severe combined immunodeficiency mouse chimeras by anti-endoglin (CD105) monoclonal antibodies, and synergy between anti-endoglin antibody and cyclophosphamide. Takahashi, N., Haba, A., Matsuno, F., Seon, B.K. Cancer Res. (2001)
- Phosphorylation of the human-transforming-growth-factor-beta-binding protein endoglin. Lastres, P., Martín-Perez, J., Langa, C., Bernabéu, C. Biochem. J. (1994)
- Endoglin increases eNOS expression by modulating Smad2 protein levels and Smad2-dependent TGF-beta signaling. Santibanez, J.F., Letamendia, A., Perez-Barriocanal, F., Silvestri, C., Saura, M., Vary, C.P., Lopez-Novoa, J.M., Attisano, L., Bernabeu, C. J. Cell. Physiol. (2007)
- Defective paracrine signalling by TGFbeta in yolk sac vasculature of endoglin mutant mice: a paradigm for hereditary haemorrhagic telangiectasia. Carvalho, R.L., Jonker, L., Goumans, M.J., Larsson, J., Bouwman, P., Karlsson, S., Dijke, P.T., Arthur, H.M., Mummery, C.L. Development (2004)
- Endoglin promotes endothelial cell proliferation and TGF-beta/ALK1 signal transduction. Lebrin, F., Goumans, M.J., Jonker, L., Carvalho, R.L., Valdimarsdottir, G., Thorikay, M., Mummery, C., Arthur, H.M., ten Dijke, P. EMBO J. (2004)
- Molecular characterization and in situ localization of murine endoglin reveal that it is a transforming growth factor-beta binding protein of endothelial and stromal cells. St-Jacques, S., Cymerman, U., Pece, N., Letarte, M. Endocrinology (1994)
- Endoglin regulates nitric oxide-dependent vasodilatation. Jerkic, M., Rivas-Elena, J.V., Prieto, M., Carrón, R., Sanz-Rodríguez, F., Pérez-Barriocanal, F., Rodríguez-Barbero, A., Bernabéu, C., López-Novoa, J.M. FASEB J. (2004)
- Identification and expression of two forms of the human transforming growth factor-beta-binding protein endoglin with distinct cytoplasmic regions. Bellón, T., Corbí, A., Lastres, P., Calés, C., Cebrián, M., Vera, S., Cheifetz, S., Massague, J., Letarte, M., Bernabéu, C. Eur. J. Immunol. (1993)
- Endoglin expression in early development is associated with vasculogenesis and angiogenesis. Jonker, L., Arthur, H.M. Mech. Dev. (2002)
- Characterization of endoglin on mouse uterine stromal cells. Ouellette, M.J., Hamel, L., Tremblay, N., Lamothe, M., St-Jacques, S. J. Reprod. Fertil. (1999)
- Reduced tumor growth and angiogenesis in endoglin-haploinsufficient mice. D??wel, A., Eleno, N., Jerkic, M., Arevalo, M., Bola??os, J.P., Bernabeu, C., L??pez-Novoa, J.M. Tumour Biol. (2007)
- Endoglin upregulation during experimental renal interstitial fibrosis in mice. Rodríguez-Peña, A., Eleno, N., Düwell, A., Arévalo, M., Pérez-Barriocanal, F., Flores, O., Docherty, N., Bernabeu, C., Letarte, M., López-Novoa, J.M. Hypertension (2002)
- Endoglin, an ancillary TGFbeta receptor, is required for extraembryonic angiogenesis and plays a key role in heart development. Arthur, H.M., Ure, J., Smith, A.J., Renforth, G., Wilson, D.I., Torsney, E., Charlton, R., Parums, D.V., Jowett, T., Marchuk, D.A., Burn, J., Diamond, A.G. Dev. Biol. (2000)