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Gene Review

UBAP1  -  ubiquitin associated protein 1

Homo sapiens

Synonyms: NAG20, Nasopharyngeal carcinoma-associated gene 20 protein, UAP, UBAP, UBAP-1, ...
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Disease relevance of UBAP1


High impact information on UBAP1

  • HHR23A, a protein implicated in nucleotide excision repair, belongs to a class of proteins containing both a ubiquitin-like (Ubl) domain and one or more ubiquitin-associated (UBA) domains, suggesting a role in the ubiquitin-proteasome pathway as well [6].
  • The presence of UBA domains provides a possible link between DNA methylation and ubiquitin/proteasome pathways [7].
  • Mutational analysis of the UBA domain reveals that the conserved hydrophobic patch MGF as well as the conserved leucine in helix 2 are necessary for binding polyubiquitinated proteins and for sequestration-aggregate formation [8].
  • Furthermore, the UBA domain of p62 was necessary for aggregate sequestration and cell survival [8].
  • The effects of the polyglutamine repeat protein ataxin-1 on the UbL-UBA protein A1Up [9].

Chemical compound and disease context of UBAP1

  • In this study, we show the presence of a substance associated with auxin activity, identified as indole-3-butyric acid (IBA), in Azospirillum brasilense UAP 154 growth medium [10].
  • The organic matrix extracted from kidney stones contained a protein antigenically related to I alpha I. We conclude that UAP is a member of I alpha I family taking part in inhibiting calcium oxalate crystallization, and modulating the formation of stones in the urinary tract [11].
  • BACKGROUND: The purpose of the study was to prospectively evaluate the protective effect of nicorandil during percutaneous coronary intervention (PCI) in patients with unstable angina (UAP) [12].

Biological context of UBAP1


Anatomical context of UBAP1


Associations of UBAP1 with chemical compounds

  • Rad23 ubiquitin-associated domains (UBA) inhibit 26 S proteasome-catalyzed proteolysis by sequestering lysine 48-linked polyubiquitin chains [21].
  • Uronic-acid-rich protein (UAP) is a new urinary macromolecule which strongly inhibits calcium oxalate crystal formation [22].
  • These included heat shock proteins (119.m00119 and 279.m00091), cyst wall glycoprotein Jacob (33.m00261), and ubiquitin-associated proteins (16.m00343; 195.m00092) [23].
  • In the present study human and rat AM were reacted with a range of environmental particles, including oil fly ash (OFA), diesel dust (DD), and ambient air particles (UAP) collected in four urban centers [24].
  • LPS priming amplified TNF production by both rat and human AMs in response to UAP and CAPs but not inert TiO2 [25].

Other interactions of UBAP1


Analytical, diagnostic and therapeutic context of UBAP1

  • Here, we report the results of a quantitative study of the interaction of K48-linked polyubiquitin chains with UBA domains of the DNA repair/proteolysis protein HHR23A, using surface plasmon resonance and other approaches [28].
  • UAP exhibited a strong calcium oxalate crystallization inhibitory activity [29].
  • Failed deployment occurred with nine stents in SAP patients, v four in UAP patients (NS) [5].
  • On Western blotting, bikunin antibody immunoreacted with UAP and both urinary and plasma bikunins [29].
  • The diagnostic sensitivity of Trop T for the detection of minor myocardial damage in UAP patients was the same as for cTnT ELISA [30].


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  3. AJvW-2, an anti-vWF monoclonal antibody, inhibits enhanced platelet aggregation induced by high shear stress in platelet-rich plasma from patients with acute coronary syndromes. Eto, K., Isshiki, T., Yamamoto, H., Takeshita, S., Ochiai, M., Yokoyama, N., Yoshimoto, R., Ikeda, Y., Sato, T. Arterioscler. Thromb. Vasc. Biol. (1999) [Pubmed]
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  9. The effects of the polyglutamine repeat protein ataxin-1 on the UbL-UBA protein A1Up. Riley, B.E., Xu, Y., Zoghbi, H.Y., Orr, H.T. J. Biol. Chem. (2004) [Pubmed]
  10. Indole-3-butyric acid (IBA) production in culture medium by wild strain Azospirillum brasilense. Martínez-Morales, L.J., Soto-Urzúa, L., Baca, B.E., Sánchez-Ahédo, J.A. FEMS Microbiol. Lett. (2003) [Pubmed]
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  13. Isolation and characterization of a novel cDNA, UBAP1, derived from the tumor suppressor locus in human chromosome 9p21-22. Qian, J., Yang, J., Zhang, X., Zhang, B., Wang, J., Zhou, M., Tang, K., Li, W., Zeng, Z., Zhao, X., Shen, S., Li, G. J. Cancer Res. Clin. Oncol. (2001) [Pubmed]
  14. Paget's Disease of Bone in the French Population: Novel SQSTM1 Mutations, Functional Analysis, and Genotype-Phenotype Correlations. Collet, C., Michou, L., Audran, M., Chasseigneaux, S., Hilliquin, P., Bardin, T., Lemaire, I., Cornélis, F., Launay, J.M., Orcel, P., Laplanche, J.L. J. Bone Miner. Res. (2007) [Pubmed]
  15. Novel UBA domain mutations of SQSTM1 in Paget's disease of bone: genotype phenotype correlation, functional analysis, and structural consequences. Hocking, L.J., Lucas, G.J., Daroszewska, A., Cundy, T., Nicholson, G.C., Donath, J., Walsh, J.P., Finlayson, C., Cavey, J.R., Ciani, B., Sheppard, P.W., Searle, M.S., Layfield, R., Ralston, S.H. J. Bone Miner. Res. (2004) [Pubmed]
  16. Ubiquitin-associated domain mutations of SQSTM1 in Paget's disease of bone: evidence for a founder effect in patients of British descent. Lucas, G.J., Hocking, L.J., Daroszewska, A., Cundy, T., Nicholson, G.C., Walsh, J.P., Fraser, W.D., Meier, C., Hooper, M.J., Ralston, S.H. J. Bone Miner. Res. (2005) [Pubmed]
  17. Zinc-induced PTEN protein degradation through the proteasome pathway in human airway epithelial cells. Wu, W., Wang, X., Zhang, W., Reed, W., Samet, J.M., Whang, Y.E., Ghio, A.J. J. Biol. Chem. (2003) [Pubmed]
  18. Isolation of ubiquitin-E2 (ubiquitin-conjugating enzyme) complexes from erythroleukaemia cells using immunoaffinity techniques. Takada, K., Hirakawa, T., Yokosawa, H., Okawa, Y., Taguchi, H., Ohkawa, K. Biochem. J. (2001) [Pubmed]
  19. Solution structure of the ubiquitin-associated domain of human BMSC-UbP and its complex with ubiquitin. Chang, Y.G., Song, A.X., Gao, Y.G., Shi, Y.H., Lin, X.J., Cao, X.T., Lin, D.H., Hu, H.Y. Protein Sci. (2006) [Pubmed]
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  21. Rad23 ubiquitin-associated domains (UBA) inhibit 26 S proteasome-catalyzed proteolysis by sequestering lysine 48-linked polyubiquitin chains. Raasi, S., Pickart, C.M. J. Biol. Chem. (2003) [Pubmed]
  22. Molecular characteristics of uronic-acid-rich protein, a strong inhibitor of calcium oxalate crystallization in vitro. Atmani, F., Lacour, B., Strecker, G., Parvy, P., Drüeke, T., Daudon, M. Biochem. Biophys. Res. Commun. (1993) [Pubmed]
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  25. Lipopolysaccharide priming amplifies lung macrophage tumor necrosis factor production in response to air particles. Imrich, A., Ning, Y.Y., Koziel, H., Coull, B., Kobzik, L. Toxicol. Appl. Pharmacol. (1999) [Pubmed]
  26. Structure of the catalytic and ubiquitin-associated domains of the protein kinase MARK/Par-1. Panneerselvam, S., Marx, A., Mandelkow, E.M., Mandelkow, E. Structure (2006) [Pubmed]
  27. The ubiquitin-associated domain of hPLIC-2 interacts with the proteasome. Kleijnen, M.F., Alarcon, R.M., Howley, P.M. Mol. Biol. Cell (2003) [Pubmed]
  28. Binding of polyubiquitin chains to ubiquitin-associated (UBA) domains of HHR23A. Raasi, S., Orlov, I., Fleming, K.G., Pickart, C.M. J. Mol. Biol. (2004) [Pubmed]
  29. Identification of uronic-acid-rich protein as urinary bikunin, the light chain of inter-alpha-inhibitor. Atmani, F., Mizon, J., Khan, S.R. Eur. J. Biochem. (1996) [Pubmed]
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