Disease relevance of STAB2

• The degradation of radiolabeled red cell band 3 and Sendai envelope proteins was studied after band 3 virosomes were fused with hepatoma cells as previously described (Hare, J E & Huston, M, Exp cell res 161 (1986) 317) [26] [1].
• Energy minimizations carried out on beta-hexyl glucopyranoside led to identification of a global minimum for the interface-associated glycolipid which exhibited glycosidic torsion angles in agreement with prior results (Hare, B.J., K.P. Howard, and J.H. Prestegard. 1993. Biophys. J. 64:392-398) [2].
• Of the anaerobic gram-positive cocci in the National Collection of Type Cultures deposited by Hare, Group IV is P. magnus, Group IX is P. micros and Groups I, III and VIII appear to be related to the butyrate-producing species P. asaccharolyticus and P. prevotii, but are strongly saccharolytic [3].
• Pyridostigmine responders were significantly more fatigued than non-responders on the pre-treatment Hare score, but were not significantly different with regard to age, sex, age at acute poliomyelitis, or severity of acute poliomyelitis [4].
• The Hare Psychopathy Checklist-Revised (PCL-R), Structured Clinical Interview II for DSM-IV (SCID II) and clinical interviews were used for assessment [5].

Psychiatry related information on STAB2

• The author tested the entire population (N = 42) of the Hare Krishna Temple in Melbourne on the MMPI, the General Health Questionnaire, and the Eysenck Personality Questionnaire psychometric indices and then randomly selected 6 subjects to take the Present State Examination [6].
• The child's functioning was assessed using the Revised Child Behavior Profile (RCBP), Hare Self-Esteem Scale, Depression Self-Rating Scale, Hopelessness Scale for Children, Index of Peer Relations, and a 5-point ordinal scale for scholastic reintegration [7].
• Psychopathic and matched non-psychopathic individuals, as defined by the Hare Psychopathy Checklist [The Hare Psychopath Checklist-Revised, 1991] completed the 'Reading the Mind in the Eyes' ToM Test [Journal of Child Psychology and Psychiatry, 1997;38:813] [8].
• METHODS: A large sample (n=329) of male Federal Correctional Institution inmates participated in structured interviews designed to permit diagnosis of antisocial personality disorder and to assess facets of psychopathic personality as defined by the Hare Psychopathy Checklist-Revised [9].
• The Social Self-Esteem Inventory was used as a measure of perceived social competence and the Psychopathy Checklist-Revised (PCL-R; Hare, 1991) was used as a measure of psychopathy [10].

High impact information on STAB2

• SETTING: The Department of Medical Psychology at the University of Tübingen, Tübingen, Germany. PARTICIPANTS: Ten male psychopaths as defined by the Hare Psychopathy Checklist-Revised and 10 age- and education-matched healthy male controls [11].
• The hyaluronic acid (HA) receptor for endocytosis (HARE; also designated stabilin-2 and FEEL-2) mediates systemic clearance of glycosaminoglycans from the circulatory and lymphatic systems via coated pit-mediated uptake [12].
• Although competition was observed at 37 degrees C, none of the glycosaminoglycans tested, except HA, competed for (125)I-HA binding by 190hHARE cells at 4 degrees C. Anti-HARE monoclonal antibodies #30 and #154, which do not inhibit (125)I-HA uptake mediated by the 175-kDa rat HARE, partially blocked HA endocytosis by the 190-kDa hHARE [13].
• Two hHARE isoforms (190 and 315 kDa) are present in sinusoidal endothelial cells of liver, spleen, and lymph nodes (Zhou, B., McGary, C. T., Weigel, J. A., Saxena, A., and Weigel, P. H. (2003) Glycobiology 13, 339-349) [13].
• Competition studies at 37 degrees C indicated that the 190-kDa hHARE binds HA and chondroitin better than dermatan sulfate and chondroitin sulfates A, C, D, and E, but it does not bind to heparin, heparan sulfate, or keratan sulfate [13].

Biological context of STAB2

• The average K(d) for the binding of HA to the 190-kDa hHARE at 4 degrees C was 7 nm with 118,000 total HA binding sites per cell [13].
• The deduced amino acid sequence of the clone indicated that its domain organization is similar to FEEL-1, and we named this clone FEEL-2 [14].
• Reverse transcription and PCR analysis revealed that both FEEL-1 and FEEL-2 were expressed in several tissues and expressed highly in the spleen and lymph node [14].
• Genetic studies indicated that these genotypes differed at two major loci controlling leaf blade Na(+) accumulation (R. Munns, G.J. Rebetzke, S. Husain, R.A. James, R.A. Hare [2003] Aust J Agric Res 54: 627-635) [15].
• Eighteen psychopathic individuals and 18 incarcerated control individuals, identified using the Revised Psychopathy Checklist (Hare, 1991, The Hare Psychopathy Checklist-Revised, Toronto: Multi-Health Systems), were shown slides of these three types of stimuli, and their electrodermal responses were recorded [16].

Anatomical context of STAB2

• Some 50 years ago the enzyme MAO was discovered by Hare and in the early 1930s Blaschko suggested that MAO may play an important role in the catabolism of monoamines in the central nervous system [17].

Associations of STAB2 with chemical compounds

• The human hyaluronan receptor for endocytosis (hHARE) mediates the endocytic clearance of hyaluronan (HA) and chondroitin sulfate from lymph fluid and blood [13].
• This completes the previous assignments of 1'H to 4'H resonances of the deoxyribose spin systems (Hare et al., 1983) [18].
• The enzyme which has come to be known as monoamine oxidase was discovered in liver over 60 years ago as tyramine oxidase (Hare, 1928) [19].
• Response to pyridostigmine was assessed with the Hare fatigue scale, the modified Barthel index for activities of daily living, and a modified Klingman mobility index [4].
• Blinded to their edrophonium results, the 17 patients were treated with pyridostigmine 180 mg/day for 1 month, with a subjective improvement of fatigue in 9 patients, and with a significant reduction in mean Hare fatigue scores in the entire group of 17 patients (pre = 2.71, and post = 1.71; Wilcoxan signed rank sum test, P < 0.05) [20].

Other interactions of STAB2

• Our results indicate that the HSA12 evolutionary breakpoint occurs between STAB2 and SART3 in a region spanning less than five million basepairs [21].
• Whereas stabilin-1 is expressed in sinusoidal endothelial cells and in macrophages in vivo, stabilin-2 is absent from the latter [22].

Analytical, diagnostic and therapeutic context of STAB2

• In addition, normal limbs had the Hare traction device and the Sager splint applied prior to application of the trouser and retesting of the digital arterial flow [23].
• The authors investigated the ability of children with emotional and behavioral difficulties, divided according to their Psychopathy Screening Device scores (P. J. Frick & R. D. Hare, in press), to recognize emotional facial expressions and vocal tones [24].
• In this meta-analysis, the authors coded 273 effect sizes to investigate the association between the Hare scales and a hierarchy of increasingly specific forms of institutional misconduct [25].
• As this was the first reported use of the Hare P-SCAN to provide partner ratings, norms for scorings on this assessment tool were obtained from ratings provided by a control group of a random sample of 100 women who had completed the Hare P-SCAN and provided ratings for their last male partner [26].
• Despite the widely accepted utility of assessing psychopathic personality features in forensic and clinical settings, the Hare Psychopathy Checklist-Revised (PCL-R; Hare, 1991) stands virtually alone in its ability to do so with adequate reliability and validity [27].

References