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Gene Review

STAB1  -  stabilin 1

Homo sapiens

Synonyms: CLEVER-1, FEEL-1, FEEL1, FELE-1, FEX1, ...
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Disease relevance of STAB1


High impact information on STAB1


Biological context of STAB1


Anatomical context of STAB1


Associations of STAB1 with chemical compounds


Co-localisations of STAB1


Other interactions of STAB1

  • Association of stabilin-1 was infrequently seen with p62 lck ligand-positive late endosomes and with CD63-positive lysosomes but not in lysosome-associated membrane protein-1-positive lysosomes [6].
  • In addition, we show using full-length stabilin-1 cDNA and a stabilin-1/CD44 chimera in HeLa cells that intracellular targeting is influenced by the transmembrane domain/cytoplasmic tail, which contains a putative dileucine (DXXLL) Golgi to endosomal sorting signal [10].
  • Among the most complex is stabilin-1, a large multidomain protein containing tandem fasciclin domains, epidermal growth factor-like repeats, and a C-type lectin-like hyaluronan-binding Link module, which functions as an endocytic receptor for acetylated low density lipoprotein and advanced glycation end products [10].
  • Based on the domain structures, we temporarily named it FEEL-1 (fasciclin, EGF-like, laminin-type EGF-like, and link domain-containing scavenger receptor-1) [7].
  • Antigen expression corroborates these morphologic data in that CD31, CD34, and 1F10 antigen are exclusively expressed in continuous endothelia, while MS-1 antigen is preferentially expressed in non-continuous sinusoidal endothelia [11].

Analytical, diagnostic and therapeutic context of STAB1

  • The "Clever Hans" phenomenon in animal models of schizophrenia, or homology as an important factor in comparing behavioral functions across species [12].
  • In all cases, splitting caused virtually no blood loss because subcutaneous veins were left intact, and the wounds healed well, especially in infants. 'Stab and split' is an effective alternative incision technique for minor surgery in younger children [13].
  • The Lr37 gene was identified in the cultivars Kris, Clever, Slade, Apache, Caphorn, Lorraine, Balthasar, Renan and confirmed by two PCR markers [14].
  • The study compared, by a prospective, randomized method, 6 treatment options: A: Sclerotherapy; B: High-dose sclerotherapy; C: Multiple ligations; D: Stab avulsion; E: Foam-sclerotherapy; F: Surgery (ligation) followed by sclerotherapy [15].


  1. Mannose receptor (MR) and common lymphatic endothelial and vascular endothelial receptor (CLEVER)-1 direct the binding of cancer cells to the lymph vessel endothelium. Irjala, H., Alanen, K., Grénman, R., Heikkilä, P., Joensuu, H., Jalkanen, S. Cancer Res. (2003) [Pubmed]
  2. Inducible expression of MS-1 high-molecular-weight protein by endothelial cells of continuous origin and by dendritic cells/macrophages in vivo and in vitro. Goerdt, S., Bhardwaj, R., Sorg, C. Am. J. Pathol. (1993) [Pubmed]
  3. Novel Function of Alternatively Activated Macrophages: Stabilin-1-Mediated Clearance of SPARC. Kzhyshkowska, J., Workman, G., Cardó-Vila, M., Arap, W., Pasqualini, R., Gratchev, A., Krusell, L., Goerdt, S., Sage, E.H. J. Immunol. (2006) [Pubmed]
  4. Penetrating injuries of chest. Stab and gunshot wounds. Mehta, D.R. New York state journal of medicine. (1982) [Pubmed]
  5. CLEVER-1 mediates lymphocyte transmigration through vascular and lymphatic endothelium. Salmi, M., Koskinen, K., Henttinen, T., Elima, K., Jalkanen, S. Blood (2004) [Pubmed]
  6. Stabilin-1 localizes to endosomes and the trans-Golgi network in human macrophages and interacts with GGA adaptors. Kzhyshkowska, J., Gratchev, A., Martens, J.H., Pervushina, O., Mamidi, S., Johansson, S., Schledzewski, K., Hansen, B., He, X., Tang, J., Nakayama, K., Goerdt, S. J. Leukoc. Biol. (2004) [Pubmed]
  7. FEEL-1, a novel scavenger receptor with in vitro bacteria-binding and angiogenesis-modulating activities. Adachi, H., Tsujimoto, M. J. Biol. Chem. (2002) [Pubmed]
  8. A novel DNA-binding motif in the nuclear matrix attachment DNA-binding protein SATB1. Nakagomi, K., Kohwi, Y., Dickinson, L.A., Kohwi-Shigematsu, T. Mol. Cell. Biol. (1994) [Pubmed]
  9. Photoinduced bonding of endogenous ecdysterone to salivary gland chromosomes of Chironomus tentans. Gronemeyer, H., Hameister, H., Pongs, O. Chromosoma (1981) [Pubmed]
  10. Rapid plasma membrane-endosomal trafficking of the lymph node sinus and high endothelial venule scavenger receptor/homing receptor stabilin-1 (FEEL-1/CLEVER-1). Prevo, R., Banerji, S., Ni, J., Jackson, D.G. J. Biol. Chem. (2004) [Pubmed]
  11. Endothelial heterogeneity and the acquired immunodeficiency syndrome: a paradigm for the pathogenesis of vascular disorders. Goerdt, S., Sorg, C. The Clinical investigator. (1992) [Pubmed]
  12. The "Clever Hans" phenomenon in animal models of schizophrenia, or homology as an important factor in comparing behavioral functions across species. Ahlenius, S. Perspect. Biol. Med. (1991) [Pubmed]
  13. 'Stab and Split': a 'bloodless' and 'scarless' skin incision technique for minor surgery. Yamataka, A., Pringle, K.C. The Australian and New Zealand journal of surgery. (1999) [Pubmed]
  14. Identifying leaf rust resistance genes and mapping gene Lr37 on the microsatellite map of wheat. Błaszczyk, L., Goyeau, H., Huang, X.Q., Röder, M., Stepień, L., Chełkowski, J. Cell. Mol. Biol. Lett. (2004) [Pubmed]
  15. Foam-sclerotherapy, surgery, sclerotherapy, and combined treatment for varicose veins: a 10-year, prospective, randomized, controlled, trial (VEDICO trial). Belcaro, G., Cesarone, M.R., Di Renzo, A., Brandolini, R., Coen, L., Acerbi, G., Marelli, C., Errichi, B.M., Malouf, M., Myers, K., Christopoulos, D., Nicolaides, A., Geroulakos, G., Vasdekis, S., Simeone, E., Ricci, A., Ruffini, I., Stuard, S., Ippolito, E., Bavera, P., Georgiev, M., Corsi, M., Scoccianti, M., Cornelli, U., Caizzi, N., Dugall, M., Christopoulos, D., Veller, M., Venniker, R., Cazaubon, M., Griffin, M. Angiology. (2003) [Pubmed]
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