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Gene Review

HRASLS  -  HRAS-like suppressor

Homo sapiens

Synonyms: A-C1, H-REV107, HRAS-like suppressor 1, HRASLS1, HRSL1, ...
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Disease relevance of HRASLS

  • CIMP-N, CIMP-I, and CIMP-H status was determined by the number (0, 1-3, and 4-5, respectively) of methylated marker genes (LOX, HRASLS, FLNc, HAND1, and TM), that were newly identified as highly methylated in gastric cancer cell lines [1].
  • A strong hH-Rev107 gene expression was observed in normal testis as well as in samples with preinvasive carcinoma in situ but was completely absent in overt tumors, both seminomas and non-seminomas [2].
  • When challenged with geminiviruses, accumulation of viral DNA was reduced by up to 98% compared to controls, providing evidence that integration of AC1 initiates protection against viral infection via a post-transcriptional gene silencing mechanism [3].
  • Integration of the AC1 gene (which encodes the replication-associated protein) from African cassava mosaic virus imparted resistance against the homologous virus and provided strong cross-protection against two heterologous species of cassava-infecting geminiviruses [3].
  • However, no similarities could be detected between HSD 28 and a recently determined 3 alpha-HSD sequence from the ATCC 11996 Comamonas strain [4].

High impact information on HRASLS


Biological context of HRASLS


Anatomical context of HRASLS


Associations of HRASLS with chemical compounds


Other interactions of HRASLS


Analytical, diagnostic and therapeutic context of HRASLS


  1. CpG island methylation status in gastric carcinoma with and without infection of Epstein-Barr virus. Chang, M.S., Uozaki, H., Chong, J.M., Ushiku, T., Sakuma, K., Ishikawa, S., Hino, R., Barua, R.R., Iwasaki, Y., Arai, K., Fujii, H., Nagai, H., Fukayama, M. Clin. Cancer Res. (2006) [Pubmed]
  2. hH-Rev107, a class II tumor suppressor gene, is expressed by post-meiotic testicular germ cells and CIS cells but not by human testicular germ cell tumors. Siegrist, S., Féral, C., Chami, M., Solhonne, B., Mattéi, M.G., Rajpert-De Meyts, E., Guellaën, G., Bulle, F. Oncogene (2001) [Pubmed]
  3. Broad spectrum resistance to ssDNA viruses associated with transgene-induced gene silencing in cassava. Chellappan, P., Masona, M.V., Vanitharani, R., Taylor, N.J., Fauquet, C.M. Plant Mol. Biol. (2004) [Pubmed]
  4. Characterization of a 3 alpha-hydroxysteroid dehydrogenase/carbonyl reductase from the gram-negative bacterium Comamonas testosteroni. Oppermann, U.C., Maser, E. Eur. J. Biochem. (1996) [Pubmed]
  5. Lysyl oxidase is a tumor suppressor gene inactivated by methylation and loss of heterozygosity in human gastric cancers. Kaneda, A., Wakazono, K., Tsukamoto, T., Watanabe, N., Yagi, Y., Tatematsu, M., Kaminishi, M., Sugimura, T., Ushijima, T. Cancer Res. (2004) [Pubmed]
  6. Identification of silencing of nine genes in human gastric cancers. Kaneda, A., Kaminishi, M., Yanagihara, K., Sugimura, T., Ushijima, T. Cancer Res. (2002) [Pubmed]
  7. CpG island promoter hypermethylation of the Ras-effector gene NORE1A occurs in the context of a wild-type K-ras in lung cancer. Irimia, M., Fraga, M.F., Sanchez-Cespedes, M., Esteller, M. Oncogene (2004) [Pubmed]
  8. Isolation, characterization, and chromosome mapping of a human A-C1 Ha-Ras suppressor gene (HRASLS). Ito, H., Akiyama, H., Shigeno, C., Nakamura, T. Cytogenet. Cell Genet. (2001) [Pubmed]
  9. Differential expression of membrane and soluble adenylyl cyclase isoforms in cytotrophoblast cells and syncytiotrophoblasts of human placenta. Bernatchez, R., Belkacemi, L., Rassart, E., Daoud, G., Simoneau, L., Lafond, J. Placenta (2003) [Pubmed]
  10. Why calcium-stimulated adenylyl cyclases? Ferguson, G.D., Storm, D.R. Physiology (Bethesda, Md.) (2004) [Pubmed]
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